Atrial fibrillation, stroke, and quality of life.

Abstract:

:Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As the incidence of atrial fibrillation rises with age, the balance of controlling stroke risk and limiting major hemorrhage on anticoagulation has become increasingly critical in elderly patients. Appreciation of more extensive risk factors has made it possible to identify patients at very low risk of thromboembolism and higher risk of bleeding. However, practice guidelines in the United States and abroad have occasionally divergent viewpoints regarding how to best manage patients in various risk strata. Options for stroke prevention have expanded with novel antithrombotics and promising mechanical alternatives to anticoagulation, which may be at least as effective in preventing stroke without increasing bleeding risk. Catheter ablation has demonstrated impressive success at preventing atrial fibrillation recurrence in selected patients, and has the potential to further improve outcomes. In addition, the role of antiplatelet medications in patients deemed unsuitable for anticoagulation has been better clarified, although novel agents require further study to assess their impact on thromboembolism. High-bleeding risks associated with the concomitant use of multiple antithrombotics remains a major obstacle in patients with indications for both antiplatelet and anticoagulant therapy.

journal_name

Ann N Y Acad Sci

authors

Chinitz JS,Castellano JM,Kovacic JC,Fuster V

doi

10.1111/j.1749-6632.2012.06494.x

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

140-50

eissn

0077-8923

issn

1749-6632

journal_volume

1254

pub_type

杂志文章,评审
  • Complex networks emerging during choir singing.

    abstract::Choir singing is positively associated with well-being and quality of life, and requires the coordination of physiological systems within and across individuals. Informed by models of interpersonal action coordination, we delineate the network topography of choir singing by analyzing cross-frequency couplings and with...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13940

    authors: Müller V,Delius JAM,Lindenberger U

    更新日期:2018-11-01 00:00:00

  • Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.

    abstract::Inflammation plays a key role in excessive bone loss in conditions such as rheumatoid arthritis and periodontitis. An important paradigm in immunology is that inflammatory factors activate feedback inhibition mechanisms to restrain inflammation and limit associated tissue damage. We hypothesized that inflammatory fact...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06217.x

    authors: Ivashkiv LB,Zhao B,Park-Min KH,Takami M

    更新日期:2011-11-01 00:00:00

  • Information processing in the parabrachial nucleus of the pons.

    abstract::As the second synapse in the central gustatory pathway of the rodent, the parabrachial nucleus of the pons (PbN) receives information about taste stimuli directly from the nucleus of the solitary tract (NTS). Data show that NTS cells amplify taste responses before transmitting taste-related signals to the PbN. NTS cel...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03903.x

    authors: Di Lorenzo PM,Platt D,Victor JD

    更新日期:2009-07-01 00:00:00

  • What is animal happiness?

    abstract::Today, we see a growing concern for the quality of life of nonhuman animals and an accompanying call for viable means of assessing how well animals thrive. Past research focused on minimizing negatives such as stress, while more recent endeavors strive to promote positives such as happiness. But what is animal happine...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13983

    authors: Webb LE,Veenhoven R,Harfeld JL,Jensen MB

    更新日期:2019-02-01 00:00:00

  • Neocortex in early mammals and its subsequent variations.

    abstract::Neocortex is an important part of the mammalian brain that is quite different from its homologue of the dorsal cortex in the reptilian brain. Whereas dorsal cortex is small, thin, and composed of a single layer of neurons, neocortex is thick and has six layers, while being variable across species in size, number of fu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.05981.x

    authors: Kaas JH

    更新日期:2011-04-01 00:00:00

  • Behavioral consequences of methamphetamine-induced neurotoxicity in mice: relevance to the psychopathology of methamphetamine addiction.

    abstract::Methamphetamine (METH) is a major drug of abuse in the United States. A high dose of METH given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (DA), and DA-transporter (DAT) binding sites in the striatum. In human METH-abusers, a marked decrease of the DAT in the caudate puta...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04156.x

    authors: Itzhak Y,Ali SF

    更新日期:2002-06-01 00:00:00

  • Measurement of thermal diffusivity of bovine aorta subject to finite deformation.

    abstract::The flash thermal diffusivity measurement technique is applied to tissue for the first time. Making use of its minimal contact with the specimen, the flash technique is extended to allow for well-defined, biaxial, finite strain. As an example application, the radial component of thermal diffusivity of bovine descendin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10143.x

    authors: Doss DJ,Humphrey JD,Wright NT

    更新日期:1998-09-11 00:00:00

  • Clara cell secretory protein (CC16): features as a peripheral lung biomarker.

    abstract::Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05520.x

    authors: Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

    更新日期:2000-01-01 00:00:00

  • Comparative in vitro reactivities of leukocytes from sarcoids and normals to different Kveim preparations.

    abstract::Comparative studies of in vivo and in vitro reactivities to Kveim preparations have been carried out in 45 sarcoid and 30 normal subjects. Lymphocytes of 14 of 45 sarcoids and 4 of 30 normals proliferated significantly in response to at least 1 of the 4 Kveim suspensions used for in vitro studies. The prevalence of po...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47084.x

    authors: Zweiman B,Israel HL

    更新日期:1976-01-01 00:00:00

  • Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis.

    abstract::The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1354.038

    authors: Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

    更新日期:2006-05-01 00:00:00

  • Sex steroids and human behavior: prenatal androgen exposure and sex-typical play behavior in children.

    abstract::Gonadal hormones, particularly androgens, direct certain aspects of brain development and exert permanent influences on sex-typical behavior in nonhuman mammals. Androgens also influence human behavioral development, with the most convincing evidence coming from studies of sex-typical play. Girls exposed to unusually ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1286.026

    authors: Hines M

    更新日期:2003-12-01 00:00:00

  • Reversal of immunosuppression induced by murine leukemia viruses.

    abstract::BALB/c mice infected with Rowson-Parr virus, a lymphatic leukemia virus isolated from the Friend complex, undergo a rapid depression of antibody response. Spleen cells from these mice in culture show a similar deficit in the response to stimulation with sheep red cells and inhibit the reactivity of normal splenocytes....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb41668.x

    authors: Bendinelli M,Toniolo A

    更新日期:1976-01-01 00:00:00

  • On the true role of oxygen free radicals in the living state, aging, and degenerative disorders.

    abstract::Oxyradicals are generally considered harmful byproducts of oxidative metabolism, causing molecular damage in living systems. They are implicated in various processes such as mutagenesis, aging, and series of pathological events. Although all this may be justified, evidence is accumulating that it is an oversimplified ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05649.x

    authors: Nagy IZ

    更新日期:2001-04-01 00:00:00

  • Cellular and molecular neuropathology of the parahippocampal region in schizophrenia.

    abstract::The entorhinal cortex, subiculum, and hippocampus have been regions of great interest in both clinical and neuropathological investigations of schizophrenia. Postmortem studies have identified numerous abnormalities, although many remain controversial or unconfirmed. Among the cellular and molecular neuropathological ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06732.x

    authors: Arnold SE

    更新日期:2000-06-01 00:00:00

  • Transport models of the neurotransmitter-receptor interaction.

    abstract::Recently, in membrane transport studies, we have observed the duality of ligand-binding site interactions in a structural protein membrane. Separately, the role of membrane anisotropy in the transport/catalytic behavior of an enzyme-membrane was investigated and modeled by the present authors. In this work, we are com...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1981.tb14181.x

    authors: Vieth WR,Ciftçi T

    更新日期:1981-01-01 00:00:00

  • Generation of reactive oxygen and nitrogen species in contracting skeletal muscle: potential impact on aging.

    abstract::Since the early 1980s biologists have recognized that skeletal muscle generates free radicals. Of particular interest are two closely related redox cascades--reactive oxygen species (ROS) and nitric oxide (NO) derivatives. The ROS cascade is initiated by superoxide anion radicals derived from the mitochondrial electro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb02087.x

    authors: Reid MB,Durham WJ

    更新日期:2002-04-01 00:00:00

  • Physiologic rationale for multiple sodium pump isoforms. Differential regulation of alpha 1 vs alpha 2 by ionic stimuli.

    abstract::A number of important themes emerge from our compartmental analyses of Na,K-ATPase biosynthesis in response to ionic stimuli. The ubiquitous alpha 1 beta 1 type sodium pump evolved to generate and maintain transmembrane Na+ and K+ gradients, and there are cell-type specific mechanisms of increasing synthesis and decre...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb43793.x

    authors: McDonough AA,Azuma KK,Lescale-Matys L,Tang MJ,Nakhoul F,Hensley CB,Komatsu Y

    更新日期:1992-11-30 00:00:00

  • Major genomic events and their consequences for vertebrate evolution and endocrinology.

    abstract::Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2008.03659.x

    authors: Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

    更新日期:2009-04-01 00:00:00

  • High expression of inducible nitric oxide synthase correlates with intestinal inflammation of interleukin-2-deficient mice.

    abstract::Severely inflamed colonic sections of IL-2 (-/-) mice showed up to 19-fold increased iNOS mRNA levels. The level of iNOS protein expression corresponded to the increased iNOS mRNA levels as detected by means of Western blot analysis. There was a clear, positive relationship between the level of iNOS expression and the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11131.x

    authors: Harren M,Schönfelder G,Paul M,Horak I,Riecken EO,Wiedenmann B,John M

    更新日期:1998-11-17 00:00:00

  • Fibroblasts create compartments in the extracellular space where collagen polymerizes into fibrils and fibrils associate into bundles.

    abstract::Morphogenesis in the animal kingdom is closely coupled with the intracellular synthesis and the extracellular deposition of collagen. These morphogenetically important events involve multiple steps which begin in compartments inside the cell and continue in compartments outside the cell. The movement of matrix compone...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb51173.x

    authors: Birk DE,Trelstad RL

    更新日期:1985-01-01 00:00:00

  • Expression of ICAM-1 and TNF alpha in human alveolar macrophages from lung-transplant recipients.

    abstract::Local activation of macrophages may play an important role in the immune process of pulmonary infections and in the inflammatory response of lung allograft rejection. To document macrophage activation within human lung allografts displaying various complications, we have investigated ICAM-1 expression in freshly isola...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb32575.x

    authors: Fattal-German M,Le Roy Ladurie F,Lecerf F,Berrih-Aknin S

    更新日期:1996-10-31 00:00:00

  • Imidazolines and pancreatic hormone secretion.

    abstract::A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic beta-cell. However, mounting evidence indicates that potassium channel blockade may form only part of the mechanism by which imi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb09364.x

    authors: Morgan NG,Chan SL,Mourtada M,Monks LK,Ramsden CA

    更新日期:1999-06-21 00:00:00

  • Modeling leg sections by bioelectrical impedance analysis, dual-energy X-ray absorptiometry, and anthropometry: assessing segmental muscle volume using magnetic resonance imaging as a reference.

    abstract::This study aimed to assess the value of different DXA and BIA models for predicting muscle volume in mid-thigh segments obtained by MRI. Three DXA models were used: in model A, muscle was taken to be equivalent to fat-free soft tissue; in model B the thigh segment was divided into its constituent tissues using fixed a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06471.x

    authors: Elia M,Fuller NJ,Hardingham CR,Graves M,Screaton N,Dixon AK,Ward LC

    更新日期:2000-05-01 00:00:00

  • Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.

    abstract::Tight and adherens junctions play critical roles in the barrier, adhesion, and signaling functions of epithelial and endothelial cells. How the molecular organization of these junctions is tuned to the widely diverse physiological requirements of each tissue type is not well understood. Here, we address this question ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13391

    authors: Vasileva E,Sluysmans S,Bochaton-Piallat ML,Citi S

    更新日期:2017-10-01 00:00:00

  • The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence.

    abstract::Based on the relation found to exist between low CSF 5-HIAA and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-HT metabolism is related to (auto)aggression, rather than to depression. We chall...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb27895.x

    authors: Van Praag HM,Plutchik R,Conte H

    更新日期:1986-01-01 00:00:00

  • Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.

    abstract::Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was ad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04926.x

    authors: Soffritti M,Belpoggi F,Lambertin L,Lauriola M,Padovani M,Maltoni C

    更新日期:2002-12-01 00:00:00

  • Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus.

    abstract::Mice with experimental neuropsychiatric lupus (NPSLE), induced by anti-ribosomal-P antibodies, developed depression-like behavior and a diminished sense of smell. Manganese-enhanced MRI (MEMRI) allows in vivo mapping of functional neuronal connections in the brain, including the olfactory tract. The aim of this study ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05302.x

    authors: Kivity S,Tsarfaty G,Agmon-Levin N,Blank M,Manor D,Konen E,Chapman J,Reichlin M,Wasson C,Shoenfeld Y,Kushnir T

    更新日期:2010-04-01 00:00:00

  • Advanced glycation end product free adducts are cleared by dialysis.

    abstract::Plasma advanced glycation end product (AGE) free adducts are increased up to 50-fold among patients on dialysis. We examined the ability of hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) to clear these compounds. The AGE free adducts Nepsilon-carboxymethyl-lysine (CML) and Nepsilon-(1-carboxyet...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1333.085

    authors: Agalou S,Ahmed N,Thornalley PJ,Dawnay A

    更新日期:2005-06-01 00:00:00

  • Evolution of evolvability.

    abstract::Genomic sequence data provide evidence for a common origin of life and for its evolution by genetic variation via mutation and recombination. This paper discusses the fundamental dialectic paradigm of evolution--stability versus variability--at the crossroads of molecular genetics, population genetics, ecology, and th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb08874.x

    authors: Radman M,Matic I,Taddei F

    更新日期:1999-05-18 00:00:00

  • The stimulated social brain: effects of transcranial direct current stimulation on social cognition.

    abstract::Transcranial direct current stimulation (tDCS) is an increasingly popular noninvasive neuromodulatory tool in the fields of cognitive and clinical neuroscience and psychiatry. It is an inexpensive, painless, and safe brain-stimulation technique that has proven to be effective in modulating cognitive and sensory-percep...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13098

    authors: Sellaro R,Nitsche MA,Colzato LS

    更新日期:2016-04-01 00:00:00