Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis.

Abstract:

:The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.

journal_name

Ann N Y Acad Sci

authors

Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

doi

10.1196/annals.1354.038

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

288-93

eissn

0077-8923

issn

1749-6632

pii

1067/1/288

journal_volume

1067

pub_type

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