Abstract:
:A number of important themes emerge from our compartmental analyses of Na,K-ATPase biosynthesis in response to ionic stimuli. The ubiquitous alpha 1 beta 1 type sodium pump evolved to generate and maintain transmembrane Na+ and K+ gradients, and there are cell-type specific mechanisms of increasing synthesis and decreasing degradation to control surface expression of this important "housekeeping" enzyme. Expression of alpha 2 beta-type sodium pumps may have evolved in cells designated as K+ storehouses to facilitate maintenance of extracellular K+ in the presence of K+ restriction. Finally, the specialized distribution of Na,K-ATPase (and related E1-E2 type pumps) along the renal epithelia allows for monitoring and fine control of extracellular K+ and Na+ (volume). Many interesting questions remain to be answered, and we now have the probes and techniques needed to answer them.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
McDonough AA,Azuma KK,Lescale-Matys L,Tang MJ,Nakhoul F,Hensley CB,Komatsu Ydoi
10.1111/j.1749-6632.1992.tb43793.xsubject
Has Abstractpub_date
1992-11-30 00:00:00pages
156-68; discussion 168-9eissn
0077-8923issn
1749-6632journal_volume
671pub_type
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