Abstract:
:In the basal state, patients with sarcoidosis have reduced numbers of circulating T lymphocytes and a normal number of circulating B lymphocytes. The lymphocytes show impaired DNA synthesis in response to several mitogens and antigens and impaired K-cell cytotoxicity. Circulating atypical cells of lymphocytic origin are present belonging to both T- and B-cell lineages. After work (with mobilization of lymphocytes) the T-cell deficiency is further accentuated compared with normals. Moreover, after work a deficiency in the number of circulating B cells is also encountered. The atypical cells do not increase. Compared with normals the impaired K-cell cytotoxicity and lower levels of DNA synthesis also persist. It is suggested that the deviations found in sarcoidosis are consequences of a disease process affecting the lymphoid tissues and successively replacing the normal structures. The presence in vivo of DNA-synthesizing circulating lymphocytes may indicate a persistent antigenic stimulation.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Hedfors Edoi
10.1111/j.1749-6632.1976.tb47020.xsubject
Has Abstractpub_date
1976-01-01 00:00:00pages
101-7eissn
0077-8923issn
1749-6632journal_volume
278pub_type
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