Transcriptional profiling and functional genomics reveal a role for AHR transcription factor in nephrogenesis.

abstract：:Phyloproteomics indicate common viral origin from ancient cells before archaea, bacteria, and eukaryota split and subsequent size and complexity reductions occurred. Further independent evidence for the cellular origin of viruses is reviewed for the virus order Megavirales, focusing on the family Poxviridae. Megaviral...

journal_title：Annals of the New York Academy of Sciences

authors： Seligmann H

更新日期：2019-07-01 00:00:00

abstract：:The sensory and hedonic evaluation of most food-related flavors is mainly dependent on olfactory perception. The sense of smell is able to recognize and discriminate myriads of airborne molecules with great accuracy and sensitivity. The primary processes of odor perception are mediated by the chemosensory olfactory ne...

journal_title：Annals of the New York Academy of Sciences

authors： Breer H

更新日期：2008-04-01 00:00:00

abstract：:Smooth septate junctions (sSJs) are cell-cell junctions that are thought to regulate the paracellular pathway of the intestine and renal system in arthropods. The detailed mechanism of action of sSJs is not well understood, because their molecular organization has remained elusive for a long time. Recently, two sSJ-sp...

journal_title：Annals of the New York Academy of Sciences

authors： Furuse M,Izumi Y

更新日期：2017-06-01 00:00:00

abstract：:Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selective delivery of therapeutic agents to the central nervous system. Primary cultures of brain microvessel endothelial cells offer a ...

journal_title：Annals of the New York Academy of Sciences

authors： Audus KL,Borchardt RT

更新日期：1987-01-01 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase-related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To gain a better understanding of these enzymes we performed a series of investigations including (1) in silico comparisons of their promoters; (2) real-t...

journal_title：Annals of the New York Academy of Sciences

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2005-06-01 00:00:00

abstract：:The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and no...

journal_title：Annals of the New York Academy of Sciences

authors： Cai D,Liu T

更新日期：2011-12-01 00:00:00

abstract：:Methamphetamine (METH) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (DA) and its metabolites, high-affinity DA uptake sites, and the activity of tyrosine hydroxylase. The present study was undertaken to investigate whether the relatively selective, neuronal nitric ...

journal_title：Annals of the New York Academy of Sciences

authors： Ali SF,Itzhak Y

更新日期：1998-05-30 00:00:00

abstract：:The inflammatory response in the lungs following an inhalation exposure of animals and humans to ozone (O3) is associated with macrophage stimulation, release of chemotactic agents, and neutrophilia. This study investigated the adhesive behavior of the alveolar macrophages and its relevance to the inflammatory process...

journal_title：Annals of the New York Academy of Sciences

authors： Bhalla DK,Hoffman LA,Pearson AC

更新日期：1996-10-31 00:00:00

abstract：:Smaller, more charge-intensive electrodes are needed for "safe" stimulation of the nervous system. In this paper we review critical concepts and the state of the art in electrodes. Control of charge density and charge balance are essential to avoid tissue electrolysis. Chemical criteria for "safe" stimulation are revi...

journal_title：Annals of the New York Academy of Sciences

authors： Brummer SB,Robblee LS,Hambrecht FT

更新日期：1983-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...

journal_title：Annals of the New York Academy of Sciences

authors： Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

更新日期：2006-07-01 00:00:00

abstract：:Effects of sunlight have fascinated researchers for decades because nearly every living thing on earth is likely to be exposed to sunlight and the ultraviolet (UV) fraction of it. In addition to detrimental long-term effects such as immunosuppression and skin cancer, premature aging of the skin (photoaging) is a well-...

journal_title：Annals of the New York Academy of Sciences

authors： Brenneisen P,Sies H,Scharffetter-Kochanek K

更新日期：2002-11-01 00:00:00

abstract：:We investigated Ca2+ clearance mechanisms (CCMs) at the axon terminals of mammalian central neurons: neurohypophysial (NHP) axon terminals and calyces of Held. Ca2+ transients were evoked by applying a short depolarization pulse via a patch pipette containing Ca2+ indicator dye. Quantitative analysis of the Ca2+ decay...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SH,Kim MH,Lee JY,Lee SH,Lee D,Park KH,Ho WK

更新日期：2007-03-01 00:00:00

abstract：:Congenital myasthenia (CM) constitutes a heterogeneous group of disorders with different underlying defects. The authors investigated a case of CM, presenting with congenital contractures. Endplate studies in the first year of life showed a developmental disorder of postsynaptic membranes. Clinical follow-up demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Smit LM,Veldman H,Jennekens FG,Molenaar PC,Oen BS

更新日期：1987-01-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) participates in the regulation of endochondral bone development. After the cartilage mold is established in fetal life, perichondrial cells and chondrocytes at the ends of the mold synthesize PTHrP. This ligand then acts on PTH/PTHrP receptors on chondrocytes. As chondrocyte...

journal_title：Annals of the New York Academy of Sciences

authors： Kronenberg HM

更新日期：2006-04-01 00:00:00

abstract：:In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

journal_title：Annals of the New York Academy of Sciences

authors： Larsson M,Bäckman L

更新日期：1998-11-30 00:00:00

abstract：:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

journal_title：Annals of the New York Academy of Sciences

authors： Heinemann U,Schmitz D,Eder C,Gloveli T

更新日期：2000-06-01 00:00:00

abstract：:Sex differences in social behavior are center stage in recent formulations of evolutionary psychology. Evolutionary psychology, with its emphasis on the long-term consequences of early adaptations, offers itself as an alternative meta-theory to mainstream social psychology, which emphasizes the importance of social st...

journal_title：Annals of the New York Academy of Sciences

authors： Rabinowitz VC,Valian V

更新日期：2000-04-01 00:00:00

abstract：:The CCR6 chemokine receptor is expressed by most B cells and subsets of T cells and dendritic cells (DCs) found in the gut mucosal immune system. CCL20, the single chemokine ligand for CCR6, is selectively made by the follicle-associated epithelium (FAE) overlying Peyer's patches (PPs) and isolated lymphoid follicles ...

journal_title：Annals of the New York Academy of Sciences

authors： Williams IR

更新日期：2006-08-01 00:00:00

abstract：:The CD27(+) IgD(+) B cell population, known as IgM memory, reduces with age. It is thought that this population is responsible for pneumococcal polysaccharide T-independent responses, and that the age-related reduction might be partially responsible for the increased susceptibility of older people to bacterial pathoge...

journal_title：Annals of the New York Academy of Sciences

authors： Martin V,Wu YC,Kipling D,Dunn-Walters DK

更新日期：2015-12-01 00:00:00

abstract：:Despite the aforementioned complications, noninvasive saliva collection has provided the medical and research community with an excellent medium for the monitoring of plasma steroid levels. This noninvasive method has permitted the evaluation and assessment of a multitude of endocrine studies that would have been extr...

journal_title：Annals of the New York Academy of Sciences

authors： Quissell DO

更新日期：1993-09-20 00:00:00

abstract：:Although it is clear that thrombopoietin is the primary regulator of thrombopoiesis, several lines of evidence indicate that the hormone affects multiple aspects of hematopoiesis: the in vivo administration of TPO increases marrow levels of erythroid, myeloid, and megakaryocytic progenitor cells and its genetic elimin...

journal_title：Annals of the New York Academy of Sciences

authors： Kaushansky K

更新日期：2003-05-01 00:00:00

abstract：:A common feature across all animals, including humans, is that mitochondrial bioenergetics is linked to oxidative stress, but the nature of these relationships with survival is yet to be properly defined. In this study we included 12 Drosophila simulans isofemale lines: four of each distinct mtDNA haplogroup (siI, -II...

journal_title：Annals of the New York Academy of Sciences

authors： Ballard JW,Katewa SD,Melvin RG,Chan G

更新日期：2007-10-01 00:00:00

abstract：:High concentrations of glucose induce insulin resistance and impair insulin secretion in a manner that mirrors type 2 diabetes, a phenomenon known as glucose toxicity. High concentrations of hexosamines mimic these effects, leading to the hypothesis that cells use hexosamine flux as a glucose- and satiety-sensing path...

journal_title：Annals of the New York Academy of Sciences

authors： Cooksey RC,McClain DA

更新日期：2002-06-01 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Uncertainty in exposure assessment and uncertainty in kinetic models of early effects after exposure to a toxin are addressed in this paper. Sources of uncertainty in the determination of exposure of workers in chemical industry exposed to dioxins are exhibited and a simple kinetic model for biomonitor measurements of...

journal_title：Annals of the New York Academy of Sciences

authors： Edler L

更新日期：1999-01-01 00:00:00

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:Thymosin β4 (Tβ4) is highly expressed in saliva of human newborns but not in adults. Here preliminary immunohistochemical analyses on different human tissues are reported. Immunoreactivity for Tβ4 in human salivary glands show high quantities of Tβ4 before birth, followed by downregulation of expression in adulthood. ...

journal_title：Annals of the New York Academy of Sciences

authors： Faa G,Nemolato S,Cabras T,Fanni D,Gerosa C,Fanari M,Locci A,Fanos V,Messana I,Castagnola M

更新日期：2012-10-01 00:00:00

abstract：:The perceptions of coccidioidomycosis as a medical problem has undergone sequential and dramatic metamorphoses since its first description more than a century ago. First thought to be rare and lethal, coccidioidomycosis was subsequently found to be common and often mild. During World War II, its overall impact upon la...

journal_title：Annals of the New York Academy of Sciences

authors： Galgiani JN

更新日期：2007-09-01 00:00:00

abstract：:These studies demonstrate that photochemotherapy can be successfully evaluated in animal models. The therapy mediates specific suppression of immune responses and appears to operate at the level of the effector T cells. Future studies will focus on isolation and characterization of the host response to photochemothera...

journal_title：Annals of the New York Academy of Sciences

authors： Berger CL,Edelson RL,Edwards N,Sanchez J,Coppey L,He X,Marboe C,Rose E

更新日期：1991-12-30 00:00:00