Challenging the neurobiological link between number sense and symbolic numerical abilities.

abstract：:Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association. To clarify the population-wide effect on the association of SUMO4 with type 1 diabetes, we have performed meta-analysis including ou...

journal_title：Annals of the New York Academy of Sciences

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2006-10-01 00:00:00

abstract：:Long-term exposure to cadmium (Cd) induces perturbation of kidney proximal tubular epithelial cells. Mitochondrial dysfunction in renal cortical cells may contribute to the pathogenesis of Cd-induced nephropathy. In this study, we examined the accumulation of mitochondrial DNA (mtDNA) with a large deletion and cellula...

journal_title：Annals of the New York Academy of Sciences

authors： Takaki A,Jimi S,Segawa M,Iwasaki H

更新日期：2004-04-01 00:00:00

abstract：:Gonad-stimulating substance (GSS) is the first invertebrate gonadotropic neuropeptide hormone identified in a marine invertebrate, the starfish. Here, we show expression and distribution of GSS in various organs of the starfish Asterina pectinifera. Levels of GSS were high in the radial nerves and nerve ring. GSS was ...

journal_title：Annals of the New York Academy of Sciences

authors： Mita M,Ito C,Kubota E,Nagahama Y,Shibata Y

更新日期：2009-04-01 00:00:00

abstract：:Vitamin E is essential for normal neurological function. It is the major lipid-soluble, chain-breaking antioxidant in the body, protecting the integrity of membranes by inhibiting lipid peroxidation. Mostly on the basis of symptoms of primary vitamin E deficiency, it has been demonstrated that vitamin E has a central ...

journal_title：Annals of the New York Academy of Sciences

authors： Sen CK,Khanna S,Roy S

更新日期：2004-12-01 00:00:00

abstract：:Nervous systems of helminths are highly peptidergic. Species in the phylum Nematoda (roundworms) possess at least 50 FMRFamide-related peptides (FaRPs), with more yet to be identified. To date, few non-FaRP neuropeptides have been identified in these organisms, though evidence suggests that other families are present....

journal_title：Annals of the New York Academy of Sciences

authors： Geary TG,Marks NJ,Maule AG,Bowman JW,Alexander-Bowman SJ,Day TA,Larsen MJ,Kubiak TM,Davis JP,Thompson DP

更新日期：1999-01-01 00:00:00

abstract：:Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

更新日期：2000-09-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

journal_title：Annals of the New York Academy of Sciences

authors： Haaga J,O'Connor K,Weinstein M,Wise P

更新日期：2010-08-01 00:00:00

abstract：:The cardiac myofilaments consist of a highly ordered assembly of proteins that collectively generate force in a calcium-dependent manner. Defects in myofilament function and its regulation have been implicated in various forms of acquired and inherited human heart disease. For example, during cardiac ischemia, cardiac...

journal_title：Annals of the New York Academy of Sciences

authors： Day S,Davis J,Westfall M,Metzger J

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study was to clarify the role of nitric oxide (NO) and lipid peroxidation (LPO) processes as well as the contribution of various neurotransmitters in pathophysiological mechanisms of neurotoxicity induced by amphetamine (AMPH). NO level was determined directly in brain tissues using electron paramagnet...

journal_title：Annals of the New York Academy of Sciences

authors： Bashkatova V,Kraus MM,Vanin A,Hornick A,Prast H

更新日期：2004-10-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide, exerts a variety of physiological functions through three types of G protein-coupled receptors, PAC1, VPAC1, and VAPC2. Characterization of the molecular forms of PAC1 in mouse heart revealed the presence of four types of variant r...

journal_title：Annals of the New York Academy of Sciences

authors： Ushiyama M,Sugawara H,Inoue K,Kangawa K,Yamada K,Miyata A

更新日期：2006-07-01 00:00:00

abstract：:Cognitive neuroscience research has traditionally overlooked half of the population. Arguing that variability in ovarian hormones confounds empirical findings, girls and women have been excluded from research for decades. But times are changing. This review summarizes historical trends that have led to a knowledge gap...

journal_title：Annals of the New York Academy of Sciences

authors： Beltz AM,Moser JS

更新日期：2020-03-01 00:00:00

abstract：:Septic shock is a systemic response to severe bacterial infections, generally caused by Gram-negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi-organ failure. All these effects, are induced by the generation of pro-inflammat...

journal_title：Annals of the New York Academy of Sciences

authors： Martínez C,Arranz A,Juarranz Y,Abad C,García-Gómez M,Rosignoli F,Leceta J,Gomariz RP

更新日期：2006-07-01 00:00:00

abstract：:Increased oxidation of carbohydrates and free fatty acids is a well-known phenomenon during cold stress. Nevertheless, sources of the fuels used have not been fully clarified as yet. Thus, the aim of our study was to evaluate the effect of acute cold exposure on lipid and carbohydrate metabolism in human subcutaneous ...

journal_title：Annals of the New York Academy of Sciences

authors： Koska J,Ksinantova L,Seböková E,Kvetnansky R,Klimes I,Chrousos G,Pacak K

更新日期：2002-06-01 00:00:00

abstract：:The Cape Town Case Study (CTCS) was a multi-institutional collaborative project initiated by CUBES, a knowledge networking initiative of UNESCO's Ecological Sciences Division and the Earth Institute at Columbia University. Cape Town was selected as a CUBES site on the basis of its high biological and cultural signific...

journal_title：Annals of the New York Academy of Sciences

authors： Stanvliet R,Jackson J,Davis G,De Swardt C,Mokhoele J,Thom Q,Lane BD

更新日期：2004-06-01 00:00:00

abstract：:We have evaluated different behavioral parameters in ICR (CD1) female mice of three different ages (38-39 weeks: mature; 62 weeks: late mature; 90 weeks: old), and addressed the effects of an enriched housing condition. We employed the following battery of tests: Holeboard, open field, elevated plus-maze (EPM), and fo...

journal_title：Annals of the New York Academy of Sciences

authors： Zambrana C,Marco EM,Arranz L,de Castro NM,Viveros MP,de la Fuente M

更新日期：2007-04-01 00:00:00

abstract：:These studies demonstrate that photochemotherapy can be successfully evaluated in animal models. The therapy mediates specific suppression of immune responses and appears to operate at the level of the effector T cells. Future studies will focus on isolation and characterization of the host response to photochemothera...

journal_title：Annals of the New York Academy of Sciences

authors： Berger CL,Edelson RL,Edwards N,Sanchez J,Coppey L,He X,Marboe C,Rose E

更新日期：1991-12-30 00:00:00

abstract：:This study investigates the complete genome sequences of the Nine Mile, K, and G isolates to improve our understanding of the unique virulence properties of C. burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen. ...

journal_title：Annals of the New York Academy of Sciences

authors： Beare PA,Porcella SF,Seshadri R,Samuel JE,Heinzen RA

更新日期：2005-12-01 00:00:00

abstract：:Radioactive contamination from the Chernobyl meltdown spread over 40% of Europe (including Austria, Finland, Sweden, Norway, Switzerland, Romania, Great Britain, Germany, Italy, France, Greece, Iceland, Slovenia) and wide territories in Asia (including Turkey, Georgia, Armenia, Emirates, China), northern Africa, and N...

journal_title：Annals of the New York Academy of Sciences

authors： Yablokov AV,Nesterenko VB

更新日期：2009-11-01 00:00:00

abstract：:Advances in resuscitation science have indicated that, contrary to perception, death by cardiorespiratory criteria can no longer be considered a specific moment but rather a potentially reversible process that occurs after any severe illness or accident causes the heart, lungs, and brain to stop functioning. The resul...

journal_title：Annals of the New York Academy of Sciences

authors： Parnia S

更新日期：2014-11-01 00:00:00

abstract：:In the late 1970s, Wally Welker and his colleagues published a series of papers describing the first high-resolution physiological maps of tactile mossy fiber projections to the granule cell layer of the rat. Over the subsequent decade, his laboratory continued to explore the implications of these results for cerebell...

journal_title：Annals of the New York Academy of Sciences

authors： Bower JM

更新日期：2011-04-01 00:00:00

abstract：:It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

journal_title：Annals of the New York Academy of Sciences

authors： Kamihira M,Yamada K,Hamamoto R,Iijima S

更新日期：1997-12-31 00:00:00

abstract：:The proper function of skeletal muscles relies on their ability to process signals derived from motor neurons, transmit stimuli along the muscle fibers, contract, and regenerate efficiently after injury. The dystrophin-glycoprotein complex (DGC; also called the dystrophin-associated protein complex) plays a central ro...

journal_title：Annals of the New York Academy of Sciences

authors： Gawor M,Prószyński TJ

更新日期：2018-01-01 00:00:00

abstract：:In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Ho...

journal_title：Annals of the New York Academy of Sciences

authors： Voltarelli JC,Couri CE,Stracieri AB,Oliveira MC,Moraes DA,Pieroni F,Barros GM,Madeira MI,Malmegrim KC,Foss-Freitas MC,Simões BP,Foss MC,Squiers E,Burt RK

更新日期：2008-12-01 00:00:00

abstract：:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In th...

journal_title：Annals of the New York Academy of Sciences

authors： Iwai K,Takahashi S

更新日期：1976-01-01 00:00:00

abstract：:A host of missense mutations in muscle nicotinic receptor subunits have been identified as the cause of congenital myasthenic syndromes (CMS). Two classes of CMS phenotypes have been identified: slow channel myasthenic syndromes (SCCMSs) and fast channel myasthenic syndromes (FCCMSs). Although both have similar phenot...

journal_title：Annals of the New York Academy of Sciences

authors： Sine SM,Wang HL,Ohno K,Shen XM,Lee WY,Engel AG

更新日期：2003-09-01 00:00:00

abstract：:There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced...

journal_title：Annals of the New York Academy of Sciences

authors： Rusch HL,Rosario M,Levison LM,Olivera A,Livingston WS,Wu T,Gill JM

更新日期：2019-06-01 00:00:00

abstract：:An extended parallel is developed between musical and prosodic structures, using the author's cognitively oriented music theory and recent work in generative phonology. For illustration, the sounds of a short poem by Robert Frost are treated entirely in musical terms. The poem is assigned a phonological stress grid an...

journal_title：Annals of the New York Academy of Sciences

authors： Lerdahl F

更新日期：2001-06-01 00:00:00

abstract：:With the progressive aging of the world's population, immunosenescence is rapidly becoming a clinical concern as it accounts for a higher incidence of severe infections and poor response to vaccines. To identify nutritional approaches that may counteract immunosenescence is of obvious importance in clinical practice. ...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman SL,Fisher L,German JB,Leung PS,Prince H,Selmi C,Naguwa SM,Gershwin ME

更新日期：2010-03-01 00:00:00

abstract：:5-Lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are two enzymes that are critical for the synthesis of eicosanoids, the inflammatory metabolites of arachidonic acid. Both 5-LOX and COX-2 are expressed in the brain, including in CNS neurons. The physiologic role of these proteins in neuronal functioning is not clea...

journal_title：Annals of the New York Academy of Sciences

authors： Manev H,Uz T,Manev R,Zhang Z

更新日期：2001-06-01 00:00:00