Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.

abstract：:Protein crystallization has been studied in presence or absence of buoyancy-driven convection. Gravity-driven flow was created, or suppressed, in protein solutions by means of vertically directed density gradients that were caused by generating suitable temperature gradients. The presence of enhanced mixing was demons...

journal_title：Annals of the New York Academy of Sciences

authors： Nanev CN,Penkova A,Chayen N

更新日期：2004-11-01 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:Extracellular DNA in the plasma or serum of cancer patients has been recently proposed as a source of analyzable cancer-related gene sequences (qualitative approach). Furthermore, patients with different tumor types show high levels of cell-free circulating DNA both in plasma and serum (quantitative approach) at the t...

journal_title：Annals of the New York Academy of Sciences

authors： Frattini M,Gallino G,Signoroni S,Balestra D,Battaglia L,Sozzi G,Leo E,Pilotti S,Pierotti MA

更新日期：2006-09-01 00:00:00

abstract：:Dietary and human factors have been found to be the major factors influencing the bioavailability of micronutrients, such as provitamin A carotenoid (pVAC), iron, and zinc, in biofortified crops. Dietary factors are related to food matrix structure and composition. Processing can improve pVAC bioavailability by disrup...

journal_title：Annals of the New York Academy of Sciences

authors： Bechoff A,Dhuique-Mayer C

更新日期：2017-02-01 00:00:00

abstract：:Studies of animals with spontaneous autoimmune diabetes have revealed that autoreactive T cells that mediate islet beta cell destruction can be manipulated by the administration of Th(2) cytokines. Using gene delivery to express the targeted protein, we can overcome the need for frequent administration of cytokines on...

journal_title：Annals of the New York Academy of Sciences

authors： Park L,Lee E,Lee S,Lim M,Hong H,Shin G,Park Y

更新日期：2008-12-01 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:The term intrauterine growth restriction (IUGR) is assigned to newborns with a birth weight and/or birth length below the 10th percentile for their gestational age and whose abdominal circumference is below the 2.5th percentile with pathologic restriction of fetal growth. IUGR is usually due to maternal, fetal, or pla...

journal_title：Annals of the New York Academy of Sciences

authors： Valsamakis G,Kanaka-Gantenbein C,Malamitsi-Puchner A,Mastorakos G

更新日期：2006-12-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with HLA B27. But the association is not absolute. Hence association with other HLA class I antigens and class II alleles was studied in a southern Indian population. Sixty-five patients with primary AS were typed serologically for HLA class I ...

journal_title：Annals of the New York Academy of Sciences

authors： Madhavan R,Parthiban M,Rajendran CP,Chandrasekaran AN,Zake L,Sanjeevi CB

更新日期：2002-04-01 00:00:00

abstract：:The search for tumor markers suitable for use in diagnosis and management of patients with lung cancer has met with limited success because each available marker lacks sufficient sensitivity and specificity. We have begun a collaborative study to evaluate multiple simultaneous serum markers to determine whether there ...

journal_title：Annals of the New York Academy of Sciences

authors： McIntire KR,Radovich BT,Gail MH,Go VL

更新日期：1983-01-01 00:00:00

abstract：:A diagnostic test is particularly beneficial if it reveals the level of susceptibility prior to onset of a disease process. In the case of childhood caries, such a diagnostic test affords the opportunity for preventive measures to be implemented before caries begins. Salivary glycoproteins contain a wealth of individu...

journal_title：Annals of the New York Academy of Sciences

authors： Denny PC,Denny PA,Takashima J,Galligan J,Navazesh M

更新日期：2007-03-01 00:00:00

abstract：:The membrane domain of the Na(+)/Ca(2+) exchanger (NCX) contains two conserved internal repeat sequences, designated the alpha-1 and alpha-2 repeats. We have studied the topological disposition of residues in the alpha repeats and a neighboring region by substituted cysteine accessibility scanning as well as the funct...

journal_title：Annals of the New York Academy of Sciences

authors： Shigekawa M,Iwamoto T,Uehara A,Kita S

更新日期：2002-11-01 00:00:00

abstract：:Four weeks immobilization of the right leg of aged rats (26 months old) caused a marked 31% and 27% reduction of muscle mass of the plantaris and soleus muscles, respectively. In animals treated with 0.6 mg/kg body weight of growth hormone (GH), the reduction of weight of the above muscles was only 14.7 and 16.1%, res...

journal_title：Annals of the New York Academy of Sciences

authors： Fares FA,Gruener N,Carmeli E,Reznick AZ

更新日期：1996-06-15 00:00:00

abstract：:There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize differ...

journal_title：Annals of the New York Academy of Sciences

authors： Biesalski HK

更新日期：2016-05-01 00:00:00

abstract：:In this review we will evaluate evidence that altered gene dosage and structure impacts neurodevelopment and neural connectivity through deleterious effects on synaptic structure and function, and evidence that the latter are key contributors to the risk for autism. We will review information on alterations of structu...

journal_title：Annals of the New York Academy of Sciences

authors： Smith M,Spence MA,Flodman P

更新日期：2009-01-01 00:00:00

abstract：:Deposition of amyloid beta protein in the brain is the major pathological feature of Alzheimer's disease. Amyloid beta protein is generated from beta-amyloid precursor protein by beta-secretase and gamma-secretase. Proteolytic processing of amyloid precursor protein at the beta site by BACE1 is essential to generate a...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou W,Qing H,Tong Y,Song W

更新日期：2004-12-01 00:00:00

abstract：:As part of an ongoing randomized clinical trial for childhood-abuse-related PTSD, this study examined the association between PTSD and unresolved attachment as measured by the Adult Attachment Interview in a sample of 52 female childhood-abuse survivors. Results revealed that 55% of the sample was classified as preocc...

journal_title：Annals of the New York Academy of Sciences

authors： Stovall-McClough KC,Cloitre M

更新日期：2003-12-01 00:00:00

abstract：:Sodium channels from rat and rabbit skeletal muscle have been isolated, characterized, and functionally reconstituted. These channel proteins closely resemble those purified from the eel electroplax and from rat brain. Work now in progress on the determination of the primary sequence of the 260 kDa subunit through the...

journal_title：Annals of the New York Academy of Sciences

authors： Barchi RL

更新日期：1986-01-01 00:00:00

abstract：:A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

journal_title：Annals of the New York Academy of Sciences

authors： Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

更新日期：2008-10-01 00:00:00

abstract：:Thymosin alpha 1, originally isolated as the compound responsible for reconstitution of immune function in thymectomized animal models, has enjoyed a wide-ranging clinical development program over the past decades, extending across multiple companies, indications, countries, and continents. This paper provides an over...

journal_title：Annals of the New York Academy of Sciences

authors： Tuthill C,Rios I,McBeath R

更新日期：2010-04-01 00:00:00

abstract：:Mutualistic interactions, where two interacting species have a net beneficial effect on each other's fitness, play a crucial role in the survival and evolution of many species. Despite substantial empirical and theoretical work in past decades, the impact of these interactions on natural selection is not fully underst...

journal_title：Annals of the New York Academy of Sciences

authors： Hillesland KL

更新日期：2018-06-01 00:00:00

abstract：:Advances in understanding the epidemiology of endometriosis have lagged behind other diseases because of methodologic problems related to disease definition and control selection. Nevertheless, a better picture of the epidemiology of endometriosis has emerged over the past few decades. Prevalence estimates of the dise...

journal_title：Annals of the New York Academy of Sciences

authors： Cramer DW,Missmer SA

更新日期：2002-03-01 00:00:00

abstract：:Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7...

journal_title：Annals of the New York Academy of Sciences

authors： Scott DJ,Layfield S,Riesewijk A,Morita H,Tregear GW,Bathgate RA

更新日期：2005-05-01 00:00:00

abstract：:Judicious selection of new animal models for the study of basic aging processes must combine feasibility and good use of the comparative method with evidence of antiaging adaptations, like the ability to combat oxidative damage to cells and tissues. A number of vertebrate species already in use or being developed as n...

journal_title：Annals of the New York Academy of Sciences

authors： Holmes DJ

更新日期：2004-06-01 00:00:00

abstract：:Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problem of heart donor shortage. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three-dimensio...

journal_title：Annals of the New York Academy of Sciences

authors： Leor J,Cohen S

更新日期：2004-05-01 00:00:00

abstract：:Altered calcium homeostasis may play a key role in the pathophysiology of human heart failure. Levels of sarcoplasmic reticulum (SR) proteins and sarcolemmal Na(+)-Ca2+ exchanger were analyzed by Western blot in failing and nonfailing human myocardium and related to myocardial function. Levels of the SR calcium releas...

journal_title：Annals of the New York Academy of Sciences

authors： Lehnart SE,Schillinger W,Pieske B,Prestle J,Just H,Hasenfuss G

更新日期：1998-09-16 00:00:00

abstract：:The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

journal_title：Annals of the New York Academy of Sciences

authors： Van Dijk W,Mackiewicz A

更新日期：1995-07-21 00:00:00

abstract：:Of the dideoxynucleosides described to date, the purine analogues ddA and ddI have exhibited very favorable therapeutic ratios in vitro. ddI is presently undergoing extensive phase I-II clinical trials. Whereas the action of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) is usually to convert a gi...

journal_title：Annals of the New York Academy of Sciences

authors： Fridland A,Johnson MA,Cooney DA,Ahluwalia G,Marquez VE,Driscoll JS,Johns DG

更新日期：1990-01-01 00:00:00

abstract：:Our recent studies in non-human primates have identified and characterized cerebro-ponto-cerebellar pathways involved in the control of vergence eye movements. Specifically, within the deep cerebellar nuclei and nucleus reticularis tegmenti pontis, we have identified neurons that are related to either the near respons...

journal_title：Annals of the New York Academy of Sciences

authors： Gamlin PD

更新日期：2002-04-01 00:00:00

abstract：:Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention stra...

journal_title：Annals of the New York Academy of Sciences

authors： Nelson MA,Goulet AC,Jacobs ET,Lance P

更新日期：2005-11-01 00:00:00