Collaborative study for the evaluation of multiple simultaneous markers in lung cancer.

abstract：:The prevalence of taste loss over a discrete area of the tongue or palate is unknown; however, we have identified discrete losses in three etiological groups: head trauma, upper respiratory infection, and bulimia. We have now identified discrete losses in elderly subjects. To summarize, elderly subjects show elevated ...

journal_title：Annals of the New York Academy of Sciences

authors： Bartoshuk LM

更新日期：1989-01-01 00:00:00

abstract：:A nonparametric method, isotonic regression, is proposed for analyzing a dose-response relationship and for assessing a threshold value. There are several advantages of this method compared to parametric models. No specific form of the relationship (type of model and use of the covariates) is required. The only assump...

journal_title：Annals of the New York Academy of Sciences

authors： Ulm K

更新日期：1999-01-01 00:00:00

abstract：:Cognitive enhancement, the amplification or extension of core capacities of the mind, has become a major topic in bioethics. But cognitive enhancement is a prime example of a converging technology where individual disciplines merge and issues transcend particular local discourses. This article reviews currently availa...

journal_title：Annals of the New York Academy of Sciences

authors： Sandberg A,Bostrom N

更新日期：2006-12-01 00:00:00

abstract：:Endothelial cells produce and bind to multiple basement membrane components. Fibronectin and interstitial collagens seem to promote migration and proliferation, whereas basement membrane collagen and laminin stimulate attachment and differentiation. Human umbilical vein endothelial cells will rapidly form capillary-li...

journal_title：Annals of the New York Academy of Sciences

authors： Grant DS,Kleinman HK,Martin GR

更新日期：1990-01-01 00:00:00

abstract：:In the present article we assessed exposure to polycyclic aromatic hydrocarbons (PAHs) in Italian asphalt workers (AW, n = 100), exposed to bitumen fumes and diesel exhausts, and in roadside construction workers (CW, n = 47), exposed to diesel exhausts, by means of environmental and biological monitoring. 1-hydroxypyr...

journal_title：Annals of the New York Academy of Sciences

authors： Campo L,Buratti M,Fustinoni S,Cirla PE,Martinotti I,Longhi O,Cavallo D,Foà V

更新日期：2006-09-01 00:00:00

abstract：:Management of gastroesophageal junction (GEJ) adenocarcinoma is a controversial topic. The rising incidence of this cancer requires a clear consensus to ensure proper management. Application of oncological principles for tumors of the esophagus or stomach is not possible because of comparative differences in the biolo...

journal_title：Annals of the New York Academy of Sciences

authors： Chevallay M,Bollschweiler E,Chandramohan SM,Schmidt T,Koch O,Demanzoni G,Mönig S,Allum W

更新日期：2018-12-01 00:00:00

abstract：:Lipopolysaccharide (LPS), an endotoxin that elicits the production of several cytokines, induces cardiovascular changes characterized by increased perfusion of immune organs and compensatory sympathetic vasoconstriction in other tissues. We therefore hypothesized that to adapt to altered blood flow distribution follow...

journal_title：Annals of the New York Academy of Sciences

authors： Rogausch H,Vo NT,Del Rey A,Besedovsky HO

更新日期：2000-01-01 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:Exposure to excessive levels of manganese, an essential trace element, can evoke severe psychiatric and extrapyramidal motor dysfunction closely resembling Parkinson's disease. The clinical manifestations of manganese toxicity arise from focal injury to the basal ganglia. This region, characterized by intense consumpt...

journal_title：Annals of the New York Academy of Sciences

authors： HaMai D,Bondy SC

更新日期：2004-03-01 00:00:00

abstract：:While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

更新日期：2001-12-01 00:00:00

abstract：:Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and receives cholinergic innervation, the functional roles of these receptors are not completely understood. Our results indicated that presynaptic nAChRs mediated a calcium influx that enhanced the release of both glutamate and GABA. Fura-2...

journal_title：Annals of the New York Academy of Sciences

authors： Radcliffe KA,Fisher JL,Gray R,Dani JA

更新日期：1999-04-30 00:00:00

abstract：:The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

journal_title：Annals of the New York Academy of Sciences

authors： Mundy NI,Kelly J,Theron E,Hawkins K

更新日期：2003-06-01 00:00:00

abstract：:Calcitonin gene-related peptide has been identified by immunocytochemistry within the thymus of fetal through aged adult mice. Calcitonin gene-related peptide positive nerves are observed from embryonic day 17 throughout the lifespan of the mouse. A sparse cell population positive for CGRP is first observed during the...

journal_title：Annals of the New York Academy of Sciences

authors： Bulloch K,McEwen BS,Diwa A,Radojcic T,Hausman J,Baird S

更新日期：1994-11-25 00:00:00

abstract：:The acquisition of both speech and music uses general principles: learners extract statistical regularities present in the environment. Yet, individuals who suffer from congenital amusia (commonly called tone-deafness) have experienced lifelong difficulties in acquiring basic musical skills, while their language abili...

journal_title：Annals of the New York Academy of Sciences

authors： Peretz I,Saffran J,Schön D,Gosselin N

更新日期：2012-04-01 00:00:00

abstract：:The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK polymorphism, a relative GC resistance has been demonstrated. In vivo, this was suggested by a smaller response to a dexamethasone supp...

journal_title：Annals of the New York Academy of Sciences

authors： Manenschijn L,van den Akker EL,Lamberts SW,van Rossum EF

更新日期：2009-10-01 00:00:00

abstract：:Evolutionary theories suggest that the expression of extended longevity depends on the organism's ability to shift energy from reproduction to somatic maintenance. New data led us to reexamine our older data and integrate the two into a larger picture of the genetic and metabolic alterations required if the animal is ...

journal_title：Annals of the New York Academy of Sciences

authors： Arking R,Buck S,Hwangbo DS,Lane M

更新日期：2002-04-01 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association. To clarify the population-wide effect on the association of SUMO4 with type 1 diabetes, we have performed meta-analysis including ou...

journal_title：Annals of the New York Academy of Sciences

authors： Noso S,Ikegami H,Fujisawa T,Kawabata Y,Asano K,Hiromine Y,Sugihara S,Lee I,Kawasaki E,Awata T,Ogihara T

更新日期：2006-10-01 00:00:00

abstract：:In biochemical and immunocytochemical comparisons of adhering junctions of different epithelia, we have observed differences in molecular composition not only between the intermediate filament-attached desmosomes and the actin filaments-anchoring adherens junctions but also between desmosomes of different tissues and ...

journal_title：Annals of the New York Academy of Sciences

authors： Borrmann CM,Mertens C,Schmidt A,Langbein L,Kuhn C,Franke WW

更新日期：2000-01-01 00:00:00

abstract：:SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

journal_title：Annals of the New York Academy of Sciences

authors： Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

更新日期：2009-01-01 00:00:00

abstract：:By using the selective ACE inhibitor captopril, we studied the effect of the angiotensin converting enzyme (ACE) on larval growth, metamorphosis, and reproduction in a lepidopteran species, the cotton leafworm, Spodoptera littoralis. Captopril was detrimental to adult formation and oviposition, and in female moths it ...

journal_title：Annals of the New York Academy of Sciences

authors： Vercruysse L,Gelman D,van de Velde S,Raes E,Hooghe B,Vermeirssen V,van Camp J,Smagghe G

更新日期：2005-04-01 00:00:00

abstract：:The hypothesis tested was that mutant tumor DNA shed into plasma would show predictive value for monitoring response to therapy in non-small cell lung carcinoma patients. Pretreatment plasma specimens from 25 patients on a phase I trial were evaluated, 12 with paired posttreatment specimens, and 138 patients on the So...

journal_title：Annals of the New York Academy of Sciences

authors： Kimura T,Holland WS,Kawaguchi T,Williamson SK,Chansky K,Crowley JJ,Doroshow JH,Lenz HJ,Gandara DR,Gumerlock PH

更新日期：2004-06-01 00:00:00

abstract：:The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted man...

journal_title：Annals of the New York Academy of Sciences

authors： Devarakonda K,Stanley S

更新日期：2018-01-01 00:00:00

abstract：:The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk. ...

journal_title：Annals of the New York Academy of Sciences

authors： Greiner DL,Brehm MA,Hosur V,Harlan DM,Powers AC,Shultz LD

更新日期：2011-12-01 00:00:00

abstract：:Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is a severe rickettsiosis that occurs in nearly every state of the continental USA. RMSF is endemic in Central and Southern America, with recent well-documented cases in Mexico, Costa Rica, Panama, Colombia, Brazil, and Argentina. RMSF is the most mal...

journal_title：Annals of the New York Academy of Sciences

authors： Eremeeva ME,Dasch GA

更新日期：2009-05-01 00:00:00

abstract：:Genomic sequence data provide evidence for a common origin of life and for its evolution by genetic variation via mutation and recombination. This paper discusses the fundamental dialectic paradigm of evolution--stability versus variability--at the crossroads of molecular genetics, population genetics, ecology, and th...

journal_title：Annals of the New York Academy of Sciences

authors： Radman M,Matic I,Taddei F

更新日期：1999-05-18 00:00:00

abstract：:This paper presents a system dynamics policy model of nutritional food market transformation, tracing over-time interactions between the nutritional quality of supply, consumer food choice, population health, and governmental policy. Applied to the Canadian context and with body mass index as the primary outcome, we e...

journal_title：Annals of the New York Academy of Sciences

authors： Struben J,Chan D,Dubé L

更新日期：2014-12-01 00:00:00

abstract：:Long-term changes in catecholamine levels and expression of their biosynthetic enzymes are associated with several stress-related disorders such as elevated plasma norepinephrine in posttraumatic stress disorder and increased postmortem tyrosine hydroxylase in the locus coeruleus with major depression. Stress elevates...

journal_title：Annals of the New York Academy of Sciences

authors： Sabban EL,Hebert MA,Liu X,Nankova B,Serova L

更新日期：2004-12-01 00:00:00

abstract：:These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...

journal_title：Annals of the New York Academy of Sciences

authors： Ferris CF,Brewer J

更新日期：1996-09-20 00:00:00

abstract：:Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a D-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on t...

journal_title：Annals of the New York Academy of Sciences

authors： Patzer JF 2nd,Mazariegos GV,Lopez R,Molmenti E,Gerber D,Riddervold F,Khanna A,Yin WY,Chen Y,Scott VL,Aggarwal S,Kramer DJ,Wagner RA,Zhu Y,Fulmer ML,Block GD,Amiot BP

更新日期：1999-06-18 00:00:00