Probing ion binding sites in the Na+/Ca2+ exchanger.

abstract：:Development of tick vaccines provides new opportunities for control of tick infestations and tick-borne diseases. Recently, the tick-protective protein, subolesin, was identified in a cell line derived from Ixodes scapularis by expression library immunization and a mouse model of tick infestations. While subolesin was...

journal_title：Annals of the New York Academy of Sciences

authors： Blouin EF,Manzano-Roman R,de la Fuente J,Kocan KM

更新日期：2008-12-01 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus, which emerged in 1998 from fruit bats in Malaysia and caused an outbreak of severe respiratory disease in pigs and fatal encephalitis in humans with high mortality rates. In contrast to most paramyxoviruses, NiV can infect a large variety of mammalian species. Du...

journal_title：Annals of the New York Academy of Sciences

authors： Diederich S,Maisner A

更新日期：2007-04-01 00:00:00

abstract：:A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

journal_title：Annals of the New York Academy of Sciences

authors： Casas MC,Rodríguez R,Nieto R,Redaño A

更新日期：2008-12-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:Venous ulcers are responsible for about 70% of the chronic ulcers of the lower limbs. Standard of care includes compression, dressings, debridement of devitalized tissue, and infection control. Thymosin beta 4 (Tbeta4), a synthetic copy of the naturally occurring 43 amino-acid peptide, has been found to have wound hea...

journal_title：Annals of the New York Academy of Sciences

authors： Guarnera G,DeRosa A,Camerini R,8 European sites.

更新日期：2010-04-01 00:00:00

abstract：:Abnormal function of the lymphatic vessels is associated with a variety of diseases, such as tumor metastasis and lymphedema. The development of strategies for local and controlled induction or inhibition of lymphangiogenesis would thus be of major importance for the treatment of such diseases. Two growth factors, vas...

journal_title：Annals of the New York Academy of Sciences

authors： Saaristo A,Karkkainen MJ,Alitalo K

更新日期：2002-12-01 00:00:00

abstract：:Heparins represent an efficient treatment of acute thrombosis and obstetric complications in antiphospholipid syndrome (APS). Enhanced microvesiculation of cell membranes, as detected by reduced membrane adhesion, can contribute to hypercoagulability in APS. Healthy donor IgG antibodies significantly increased beta2-g...

journal_title：Annals of the New York Academy of Sciences

authors： Frank M,Sodin-Semrl S,Rozman B,Potocnik M,Kralj-Iglic V

更新日期：2009-09-01 00:00:00

abstract：:We are used to thinking of mathematics as a symbolic activity. Here I argue that it may also be seen as a performative one. Making an analogy with music, I draw attention to the ways in which mathematics may not only be written down but also played out. ...

journal_title：Annals of the New York Academy of Sciences

authors： Wertheim M

更新日期：2019-12-01 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:Science is concerned not just with objects but also with their various aspects, such as their colors, temperatures, sizes, and shapes. These aspects, or properties, are generally thought to be of at least two kinds: primary properties, such as shape, size, and motion and secondary ones, such as temperature and color. ...

journal_title：Annals of the New York Academy of Sciences

authors： Vollmer SH

更新日期：2003-05-01 00:00:00

abstract：:The Ras proteins, which regulate intracellular signaling by a cyclic process involving interconversion between active GTP-bound and inactive GDP-bound states, play an essential role in controlling the activity of several crucial signaling pathways regulating normal cellular proliferation. Mutational activation of RAS ...

journal_title：Annals of the New York Academy of Sciences

authors： Colombo S,Peri F,Tisi R,Nicotra F,Martegani E

更新日期：2004-12-01 00:00:00

abstract：:Long-term changes in catecholamine levels and expression of their biosynthetic enzymes are associated with several stress-related disorders such as elevated plasma norepinephrine in posttraumatic stress disorder and increased postmortem tyrosine hydroxylase in the locus coeruleus with major depression. Stress elevates...

journal_title：Annals of the New York Academy of Sciences

authors： Sabban EL,Hebert MA,Liu X,Nankova B,Serova L

更新日期：2004-12-01 00:00:00

abstract：:To gain better insight into mass transfer problems in encapsulated cell systems requires a combination of experimental investigations and mathematical modeling. Specific mass transfer studies are reviewed including oxygen transfer in immobilized animal cell culture bioreactors, modeling of polymer droplet formation an...

journal_title：Annals of the New York Academy of Sciences

authors： Goosen MF

更新日期：1999-06-18 00:00:00

abstract：:The first studies of the pharmacological induction of fetal hemoglobin were conducted in patients with sickle cell disease and thalassemia. Although hydroxyurea was approved by the FDA for the treatment of sickle cell disease in 1996, no similar pharmacological agent(s) has been approved for the treatment of patients ...

journal_title：Annals of the New York Academy of Sciences

authors： Fathallah H,Sutton M,Atweh GF

更新日期：2005-01-01 00:00:00

abstract：:How can a psychoanalyst account for and recount the process of understanding the therapeutic endeavor? What happens in those moments, co-created by patient and analyst, when the consultation room comes "alive" in ways that defy easy or simplistic answers? How does an analyst come to understand psychoanalytic treatment...

journal_title：Annals of the New York Academy of Sciences

authors： Gotthold JJ

更新日期：2009-04-01 00:00:00

abstract：:The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK polymorphism, a relative GC resistance has been demonstrated. In vivo, this was suggested by a smaller response to a dexamethasone supp...

journal_title：Annals of the New York Academy of Sciences

authors： Manenschijn L,van den Akker EL,Lamberts SW,van Rossum EF

更新日期：2009-10-01 00:00:00

abstract：:A male factor is implicated in about 50% of couples treated with advanced assisted reproductive techniques (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]). An important function of spermatozoa is to deliver the paternal genome to the oocyte. However, neither the routine testing of male fertil...

journal_title：Annals of the New York Academy of Sciences

authors： Patrizio P,Sanguineti F,Sakkas D

更新日期：2008-04-01 00:00:00

abstract：:Over the past 10 years, the continual discovery of novel forms of encephalitis associated with antibodies to cell-surface or synaptic proteins has changed the paradigms for diagnosing and treating disorders that were previously unknown or mischaracterized. We review here the process of discovery, the symptoms, and the...

journal_title：Annals of the New York Academy of Sciences

authors： Leypoldt F,Armangue T,Dalmau J

更新日期：2015-03-01 00:00:00

abstract：:The observations described herein allow us to make several inferences about PKC and regulation of normal and CF Cl- channels. FIGURE 5 shows a model that summarizes these observations. In this model, for the sake of clarity, we refer to the channel as a single entity, but note that it may consist of multiple subunits ...

journal_title：Annals of the New York Academy of Sciences

authors： Welsh MJ,Li M,McCann JD,Clancy JP,Anderson MP

更新日期：1989-01-01 00:00:00

abstract：:We have previously described proopiomelanocortin (POMC) gene-expression in human normal cultured dermal fibroblasts, and its dose- and time-dependent modulation by transforming growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha). The aim of the work described here was to investigate POMC-derived ...

journal_title：Annals of the New York Academy of Sciences

authors： Teofoli P,Frezzolini A,Puddu P,De Pità O,Mauviel A,Lotti T

更新日期：1999-10-20 00:00:00

abstract：:High concentrations of glucose induce insulin resistance and impair insulin secretion in a manner that mirrors type 2 diabetes, a phenomenon known as glucose toxicity. High concentrations of hexosamines mimic these effects, leading to the hypothesis that cells use hexosamine flux as a glucose- and satiety-sensing path...

journal_title：Annals of the New York Academy of Sciences

authors： Cooksey RC,McClain DA

更新日期：2002-06-01 00:00:00

abstract：:Nanotechnology provides multifunctional agents for in vivo use that increasingly blur the distinction between pharmaceuticals and medical devices. Realization of such therapeutic nanodevices requires multidisciplinary effort that is difficult for individual device developers to sustain, and identification of appropria...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SC,Bhalerao K,Ferrari M

更新日期：2004-05-01 00:00:00

abstract：:Like many other transcription factors, the tumor suppressor protein p53 is bound to the nuclear matrix (NM). To study the interaction of p53 with the NM in more detail, we used alkaline and acidic extractions of NM proteins. It was found that there are two forms of p53, alkali- and acid-soluble, in NM of HEK293 cells ...

journal_title：Annals of the New York Academy of Sciences

authors： Lapshina MA,Parkhomenko II,Terentiev AA

更新日期：2006-12-01 00:00:00

abstract：:The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical tr...

journal_title：Annals of the New York Academy of Sciences

authors： Wolchok JD,Hodi FS,Weber JS,Allison JP,Urba WJ,Robert C,O'Day SJ,Hoos A,Humphrey R,Berman DM,Lonberg N,Korman AJ

更新日期：2013-07-01 00:00:00

abstract：:Adrenocortical androgens, including dehydroepiandrosterone (DHEA), are produced in the inner zone of the adrenal cortex that is in direct contact with the neural crest-derived catecholamine-producing chromaffin cells. DHEA has recently been identified as a crucial regulator of neuronal stem cell proliferation. Thus, D...

journal_title：Annals of the New York Academy of Sciences

authors： Ziegler CG,Sicard F,Sperber S,Ehrhart-Bornstein M,Bornstein SR,Krug AW

更新日期：2006-08-01 00:00:00

abstract：:Since the first demonstrations that mindfulness-based therapies could have a positive influence on chronic pain patients, numerous studies have been conducted with healthy individuals in an attempt to understand meditative analgesia. This review focuses explicitly on experimental pain studies of meditation and attempt...

journal_title：Annals of the New York Academy of Sciences

authors： Grant JA

更新日期：2014-01-01 00:00:00

abstract：:Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5-7% for first-degree relatives. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance. The current investigationa...

journal_title：Annals of the New York Academy of Sciences

authors： Bischoff F,Simpson JL

更新日期：2004-12-01 00:00:00

abstract：:The aim of this study is to identify immune correlates of protection against tuberculosis induced by the current vaccine, Bacille Calmette Guerin (BCG). This knowledge should be valuable for developing and testing novel tuberculosis vaccines. Blood from 5675 10-week-old South African infants, routinely vaccinated with...

journal_title：Annals of the New York Academy of Sciences

authors： Hanekom WA

更新日期：2005-12-01 00:00:00

abstract：:We have shown that drinking red wine reduces oxidation of LDL. This reduction in oxidation has been attributed to the polyphenolic compounds in red wine, but the mechanisms of absorption and metabolism of these compounds has been unclear. We therefore investigated the absorption and metabolism of polyphenols using rat...

journal_title：Annals of the New York Academy of Sciences

authors： Yamashita S,Sakane T,Harada M,Sugiura N,Koda H,Kiso Y,Sezaki H

更新日期：2002-05-01 00:00:00

abstract：:5-HT2B receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21ras. During mouse embryogenesis, a peak of 5-HT2B receptor expression is detected at the neurulation stage; we localized the 5-HT2B expression in neural crest cells, heart myocardium, and somit...

journal_title：Annals of the New York Academy of Sciences

authors： Choi DS,Kellermann O,Richard S,Colas JF,Bolaños-Jimenez F,Tournois C,Launay JM,Maroteaux L

更新日期：1998-12-15 00:00:00