Abstract:
:We have shown that drinking red wine reduces oxidation of LDL. This reduction in oxidation has been attributed to the polyphenolic compounds in red wine, but the mechanisms of absorption and metabolism of these compounds has been unclear. We therefore investigated the absorption and metabolism of polyphenols using rats to identify their active forms in biological fluids. We also investigated the effect of tartaric acid (TA), a major organic acid in wine, on the absorption of polyphenols. Our results suggested that low molecular weight polyphenols are absorbed in the intestine and metabolized to their glucuronide conjugates, which exhibit antioxidative activity in plasma, and that TA can enhance the bioavailability of wine polyphenols.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Yamashita S,Sakane T,Harada M,Sugiura N,Koda H,Kiso Y,Sezaki Hdoi
10.1111/j.1749-6632.2002.tb02934.xsubject
Has Abstractpub_date
2002-05-01 00:00:00pages
325-8eissn
0077-8923issn
1749-6632journal_volume
957pub_type
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