Abstract:
:These findings demonstrate that calcium antagonists reverse renal vasoconstriction in a variety of settings. The ability of calcium antagonists to augment GFR of the vasoconstricted kidney is striking and has also been demonstrated in a number of in vivo settings. These observations and others raise the possibility that calcium antagonists have potential utility in the treatment of a number of disorders characterized by renal ischemia and consequent renal insufficiency. Further studies to evaluate this possibility are required. The unique effects of calcium antagonists on GFR reflect a regional heterogeneity within the renal microcirculation and a preferential action of calcium antagonists on the afferent arteriole. Final resolution of the pharmacological basis for the renal hemodynamic actions of calcium antagonists will require a more complete understanding of the divergent activating mechanisms within the renal microcirculation.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Loutzenhiser R,Epstein Mdoi
10.1111/j.1749-6632.1988.tb33428.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
771-84eissn
0077-8923issn
1749-6632journal_volume
522pub_type
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