Abstract:
:Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of (+/-)Huperzine A with those of (-)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (+/-)Huperzine A has a weaker biological activity than the natural product (-)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (-)isomer.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Hanin I,Tang XC,Kindel GL,Kozikowski APdoi
10.1111/j.1749-6632.1993.tb23071.xsubject
Has Abstractpub_date
1993-09-24 00:00:00pages
304-6eissn
0077-8923issn
1749-6632journal_volume
695pub_type
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