ER stress induces the expression of Jpk, which inhibits cell cycle progression in F9 teratocarcinoma cell.

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally highly conserved neuropeptide and displays pleiotropic activity, including functioning as a neurotransmitter, neuromodulator, and neurotrophic factor. A series of recent experiments, including genetic manipulation of PACAP and its receptors, ...

journal_title：Annals of the New York Academy of Sciences

authors： Hashimoto H,Shintani N,Baba A

更新日期：2006-07-01 00:00:00

abstract：:The identification of high-affinity ligands for PPAR gamma has revealed the role of this receptor as the molecular target for the antidiabetic activity of the thiazolidinediones. The surprising observation that agonists of an adipogenic transcription factor reverse the obesity-associated disease of diabetes highlights...

journal_title：Annals of the New York Academy of Sciences

authors： Willson TM,Lehmann JM,Kliewer SA

更新日期：1996-12-27 00:00:00

abstract：:The mechanism by which neurons and neurosecretory cells govern the expression and the exocytic discharge of their clear and dense-core vesicles had remained unclear until recently when studies in the neurosecretory cell model PC12 revealed these processes to be orchestrated by the transcriptional repressor neuron rest...

journal_title：Annals of the New York Academy of Sciences

authors： D'Alessandro R,Klajn A,Meldolesi J

更新日期：2009-01-01 00:00:00

abstract：:The benefits of estrogen replacement therapy in postmenopausal women include increased quality of life, relief from specific symptoms, and the prevention of osteoporosis, genitourinary atrophy, and cardiovascular diseases. Despite these advantages, this therapy has been reported to be associated with an increased freq...

journal_title：Annals of the New York Academy of Sciences

authors： De Cecco L,Leone M,Gerbaldo D,Venturini PL,Rissone R,Messeni Leone M

更新日期：1991-01-01 00:00:00

abstract：:A male factor is implicated in about 50% of couples treated with advanced assisted reproductive techniques (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]). An important function of spermatozoa is to deliver the paternal genome to the oocyte. However, neither the routine testing of male fertil...

journal_title：Annals of the New York Academy of Sciences

authors： Patrizio P,Sanguineti F,Sakkas D

更新日期：2008-04-01 00:00:00

abstract：:Recognizing the self-activity of matter through complexification can lead to seeing evolution as a process of union. This process approach emphasizes a metaphysics of becoming rather than of being. Advances in the science of thermodynamics lead to understanding chemical self-organization as a stage in this process of ...

journal_title：Annals of the New York Academy of Sciences

authors： Salmon JF

更新日期：2003-05-01 00:00:00

abstract：:Abnormal function of the lymphatic vessels is associated with a variety of diseases, such as tumor metastasis and lymphedema. The development of strategies for local and controlled induction or inhibition of lymphangiogenesis would thus be of major importance for the treatment of such diseases. Two growth factors, vas...

journal_title：Annals of the New York Academy of Sciences

authors： Saaristo A,Karkkainen MJ,Alitalo K

更新日期：2002-12-01 00:00:00

abstract：:The identification of sensitive assay formats capable of distinguishing islet autoreactive T cells directly ex vivo in blood is a major goal in type 1 diabetes research. Whereas much effort has been made to identify suitable assay formats, relatively little attention has been paid to optimizing the quality of cell pre...

journal_title：Annals of the New York Academy of Sciences

authors： Tree TI,Roep BO,Peakman M

更新日期：2004-12-01 00:00:00

abstract：:Lesion, stimulation, and pharmacological studies point to separate hypothalamic control of pulsatile FSH and LH secretion. LH release is controlled by a region extending from the preoptic area to the anterior and mid-median eminence, whereas FSH release is controlled by a region extending from the dorsal anterior hypo...

journal_title：Annals of the New York Academy of Sciences

authors： McCann SM,Marubayashi U,Sun HQ,Yu WH

更新日期：1993-05-28 00:00:00

abstract：:The alteration of oligosaccharide structures through genetic manipulation of glycosyltransferase activities is now a reality. It is apparent that this technique has greater consequences on oligosaccharide structure when an exogenous enzyme is introduced into cells, and in particular when this enzyme is responsible for...

journal_title：Annals of the New York Academy of Sciences

authors： Youakim A,Shur BD

更新日期：1994-11-30 00:00:00

abstract：:In vitro and in vivo 31P magnetic resonance (MR) spectroscopy studies of Alzheimer's disease (AD) brain have revealed alterations in membrane phospholipid metabolism and high-energy phosphate metabolism. Mildly demented AD patients compared with control subjects have increased levels of phosphomonoesters, decreased le...

journal_title：Annals of the New York Academy of Sciences

authors： Pettegrew JW,Klunk WE,Panchalingam K,McClure RJ,Stanley JA

更新日期：1997-09-26 00:00:00

abstract：:Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions. It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions. For example, the hypercortisolemia observed in a subset of patients with depression may hav...

journal_title：Annals of the New York Academy of Sciences

authors： Wolkowitz OM,Burke H,Epel ES,Reus VI

更新日期：2009-10-01 00:00:00

abstract：:Myasthenia gravis (MG) in individuals over 40 years of age comprises three groups: early-onset MG with prolonged disease duration, late-onset MG with thymoma, and late-onset of nonthymomatous MG. The clinical features do not differ between the three groups, except that early-onset patients with prolonged disease durat...

journal_title：Annals of the New York Academy of Sciences

authors： Aarli JA,Romi F,Skeie GO,Gilhus NE

更新日期：2003-09-01 00:00:00

abstract：:In this study we investigated the impact of estrogen antagonists and of 16alpha-OHE1 (an estrogen derivative that binds to and induces transactivation of estrogen receptors) on estrogen metabolism in malignant HepG2 human liver cells featured by high estrogen sulfotransferase (EST); our aim was to clarify the potentia...

journal_title：Annals of the New York Academy of Sciences

authors： Campisi I,Granata OM,Cocciadiferro L,Calabrò M,Polito LM,Carruba G

更新日期：2009-02-01 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram RG,Wilson DD,Hansen JW

更新日期：2000-01-01 00:00:00

abstract：:Over the past two decades, many clinical trials have been conducted using different forms of estrogen therapy with and without progestin supplementation in an effort to treat diagnosed Alzheimer's disease. Design variations among these trials may account for the inconsistent results of these investigations and the per...

journal_title：Annals of the New York Academy of Sciences

authors： Mulnard RA

更新日期：2005-06-01 00:00:00

abstract：:In thalassemia, iron overload is the joint outcome of excessive iron absorption and transfusional siderosis. While iron absorption is limited by a physiologic ceiling of about 3 mg/d, plasma iron turnover in thalassemia may be 10 to 15 times normal, caused by the wasteful, ineffective erythropoiesis of an enormously e...

journal_title：Annals of the New York Academy of Sciences

authors： Hershko C,Link G,Cabantchik I

更新日期：1998-06-30 00:00:00

abstract：:Reactive oxygen species have been known to cause DNA damage and induce apoptosis. During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis. Recent reports have shown that NF-kappaB plays a critica...

journal_title：Annals of the New York Academy of Sciences

authors： Song JY,Lim JW,Kim H,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:Adolescence and emerging adulthood form a critical time period for the achievement of optimal health and nutrition across all stages of the life course. We undertook a review of published literature and global data repositories for information on nutrition levels, trends, and patterns among young people aged 10-24 yea...

journal_title：Annals of the New York Academy of Sciences

authors： Akseer N,Al-Gashm S,Mehta S,Mokdad A,Bhutta ZA

更新日期：2017-04-01 00:00:00

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:Gluten sensitivity is an autoimmune disease that usually causes intestinal atrophy resulting in a malabsorption syndrome known as celiac disease. However, gluten sensitivity may involve several organs and is often associated with extraintestinal manifestations. Typically, patients with celiac disease have circulating ...

journal_title：Annals of the New York Academy of Sciences

authors： Boscolo S,Sarich A,Lorenzon A,Passoni M,Rui V,Stebel M,Sblattero D,Marzari R,Hadjivassiliou M,Tongiorgi E

更新日期：2007-06-01 00:00:00

abstract：:Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Reifsnyder PC,Ryzhov S,Flurkey K,Anunciado-Koza RP,Mills I,Harrison DE,Koza RA

更新日期：2018-04-01 00:00:00

abstract：:We have previously demonstrated that wild-type herpes simplex virus type 1 (HSV-1), as well as nonreplicating UV-inactivated HSV-1, promptly activates the nuclear factor-kappaB (NF-kappaB) in U937 monocytoid cells and that glycoprotein D (gD) of HSV-1 is sufficient by itself to exert a similar effect. We then investig...

journal_title：Annals of the New York Academy of Sciences

authors： Teresa Sciortino M,Medici MA,Marino-Merlo F,Zaccaria D,Giuffrè M,Venuti A,Grelli S,Mastino A

更新日期：2007-01-01 00:00:00

abstract：:To study the role of the LDL receptor pathway for the maintenance of alpha-tocopherol concentrations in tissues of intact animals, we have compared vitamin E levels in plasma and tissues of normal rabbits and WHHL rabbits. WHHL rabbits are deficient in LDL receptor activity. For WHHL rabbits, alpha-tocopherol plasma c...

journal_title：Annals of the New York Academy of Sciences

authors： Cohn W,Kuhn H

更新日期：1989-01-01 00:00:00

abstract：:The first studies of the pharmacological induction of fetal hemoglobin were conducted in patients with sickle cell disease and thalassemia. Although hydroxyurea was approved by the FDA for the treatment of sickle cell disease in 1996, no similar pharmacological agent(s) has been approved for the treatment of patients ...

journal_title：Annals of the New York Academy of Sciences

authors： Fathallah H,Sutton M,Atweh GF

更新日期：2005-01-01 00:00:00

abstract：:Relaxin has been validated as a cardiotropic hormone, being produced by the heart and acting on specific heart receptors. Evidence is accumulating that it could hamper the pathophysiologic mechanisms of ischemic heart disease. Time is ripe to study relaxin as a cardiotropic drug, as recombinant human relaxin (hrRLX) i...

journal_title：Annals of the New York Academy of Sciences

authors： Bani D,Nistri S,Sacchi TB,Bigazzi M

更新日期：2005-05-01 00:00:00

abstract：:By using the selective ACE inhibitor captopril, we studied the effect of the angiotensin converting enzyme (ACE) on larval growth, metamorphosis, and reproduction in a lepidopteran species, the cotton leafworm, Spodoptera littoralis. Captopril was detrimental to adult formation and oviposition, and in female moths it ...

journal_title：Annals of the New York Academy of Sciences

authors： Vercruysse L,Gelman D,van de Velde S,Raes E,Hooghe B,Vermeirssen V,van Camp J,Smagghe G

更新日期：2005-04-01 00:00:00

abstract：:In this chapter, we examine the possibility that negative emotions contribute to the relationship between socioeconomic status (SES) and health. A model of the associations among SES, emotion, and health is presented first. We then review the evidence for this model, showing associations of SES with depression, hopele...

journal_title：Annals of the New York Academy of Sciences

authors： Gallo LC,Matthews KA

更新日期：1999-01-01 00:00:00

abstract：:Bacterial, plasmid, and synthetic DNA containing unmethylated CpG dinucleotides in specific sequence contexts activate the vertebrate innate immune system. A pattern recognition receptor (PRR), toll-like receptor 9 (TLR9), recognizes CpG DNA and activates signaling cascade leading to the secretion of a number of cytok...

journal_title：Annals of the New York Academy of Sciences

authors： Agrawal S,Kandimalla ER

更新日期：2003-12-01 00:00:00