Multi-scale model of O2 transport and metabolism: response to exercise.

abstract：:A complete amino acid sequence for rat testis P-450 17 alpha was deduced from nucleotide analysis of a cDNA clone isolated from a rat Leydig cell library. This cDNA expressed in COS-1 cells both 17 alpha-hydroxylase and 17,20 lyase activities. Rat P-450 17 alpha exhibited significant similarity to the nucleotide and d...

journal_title：Annals of the New York Academy of Sciences

authors： Dufau ML,Minegishi T,Buczko E,Kitamura M,Delgado C,Namiki M

更新日期：1989-01-01 00:00:00

abstract：:Neocortex is an important part of the mammalian brain that is quite different from its homologue of the dorsal cortex in the reptilian brain. Whereas dorsal cortex is small, thin, and composed of a single layer of neurons, neocortex is thick and has six layers, while being variable across species in size, number of fu...

journal_title：Annals of the New York Academy of Sciences

authors： Kaas JH

更新日期：2011-04-01 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:Mouse and human DNA sequences from centromeric and ribosomal domains were labeled with biotinylated deoxynucleotides and hybridized in situ to paraformaldehyde-fixed tissue culture cells. Centromeres were widely dispersed in most of these interphase nuclei. At late G2 phases of the cell cycle, centromeres appeared to ...

journal_title：Annals of the New York Academy of Sciences

authors： Manuelidis L

更新日期：1985-01-01 00:00:00

abstract：:The biological consequences of chronic consumption of Maillard reaction products (MRPs) on renal function in health and renal disease are still incompletely understood. We investigated the metabolic and renal effects of a diet with varying MRP content in healthy and subtotally nephrectomized rats. Male Wistar rats wer...

journal_title：Annals of the New York Academy of Sciences

authors： Sebeková K,Hofmann T,Boor P,Sebeková K Jr,Ulicná O,Erbersdobler HF,Baynes JW,Thorpe SR,Heidland A,Somoza V

更新日期：2005-06-01 00:00:00

abstract：:To evaluate the effect of Lactobacillus casei on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day -2 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animal...

journal_title：Annals of the New York Academy of Sciences

authors： Bautista CR,Alvarez JA,Mosqueda JJ,Falcon A,Ramos JA,Rojas C,Figueroa JV,Ku M

更新日期：2008-12-01 00:00:00

abstract：:Exposure of LLC-PK1 epithelial cell cultures to phorbol ester tumor promoters causes immediate translocation of protein kinase C-alpha (PKC-alpha) from cytosolic to membrane-associated compartments. With a very similar time course, a dramatic and sustained increase in tight junctional (paracellular) permeability occur...

journal_title：Annals of the New York Academy of Sciences

authors： Mullin JM,Laughlin KV,Ginanni N,Marano CW,Clarke HM,Peralta Soler A

更新日期：2000-01-01 00:00:00

abstract：:Oropharyngeal dysphagia (OD) is a swallowing disorder caused by congenital abnormalities and structural damage and disease-associated damage of the oral cavity, pharynx, and upper esophageal sphincter. Patients with OD lack the protective mechanisms necessary for effective swallowing, exhibiting difficulty controlling...

journal_title：Annals of the New York Academy of Sciences

authors： Rofes L,Clavé P,Ouyang A,Scharitzer M,Pokieser P,Vilardell N,Ortega O

更新日期：2013-10-01 00:00:00

abstract：:The development of an integrated system for the continuous, automated production of pure cell culture derived proteins is discussed. The system comprises a cell culture subunit for the continuous culture of mammalian cells and a purification subunit linked on-line to the cell culture subunit. The cells are compartment...

journal_title：Annals of the New York Academy of Sciences

authors： Grandics P,Szathmary S,Szathmary Z,O'Neill T

更新日期：1991-12-27 00:00:00

abstract：:Maize (Zea mays), also called corn, is believed to have originated in central Mexico 7000 years ago from a wild grass, and Native Americans transformed maize into a better source of food. Maize contains approximately 72% starch, 10% protein, and 4% fat, supplying an energy density of 365 Kcal/100 g and is grown throug...

journal_title：Annals of the New York Academy of Sciences

authors： Ranum P,Peña-Rosas JP,Garcia-Casal MN

更新日期：2014-04-01 00:00:00

abstract：:Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq-Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongo...

journal_title：Annals of the New York Academy of Sciences

authors： Mishra N,Raina K,Agarwal R

更新日期：2020-12-10 00:00:00

abstract：:Several reports addressed the issue of how the alternative splicing of exon 7 and 8 in the APP pre-mRNA is regulated in different tissues. Of special interest here was the potential involvement of exon 7 containing APP splice isoforms, since this exon codes for a serine protease inhibitor and is therefore of putative ...

journal_title：Annals of the New York Academy of Sciences

authors： Sandbrink R,Banati R,Masters CL,Beyreuther K,König G

更新日期：1993-09-24 00:00:00

abstract：:Pregnancy at high altitude (>2700 m) is associated with higher rates of fetal growth restriction and preeclampsia as well as alterations in placentation, including increased villous vascularization and reduced remodeling of maternal spiral arteries. Because circulatory fetal DNA concentrations were shown to be enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Zhong XY,Wang Y,Chen S,Labu,Pubuzhuoma,Gesangzhuogab,Ouzhuwangmu,Hahn C,Holzgreve W,Hahn S

更新日期：2004-06-01 00:00:00

abstract：:Quantum dots (QDs) are fluorescent nanocrystals that are emerging as fine alternatives to the conventional organic dyes. They have several advantages including greater photostability and a wider range of excitation-emission wavelengths. By using mortalin staining as a model, we initially demonstrated that the QDs are ...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul Z,Yaguchi T,Chiura HX,Kaul SC,Wadhwa R

更新日期：2007-04-01 00:00:00

abstract：:The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effect...

journal_title：Annals of the New York Academy of Sciences

authors： Hopkins DR,Richards FO Jr,Ruiz-Tiben E,Emerson P,Withers PC Jr

更新日期：2008-01-01 00:00:00

abstract：:Toluene, a volatile hydrocarbon found in a variety of chemical compounds, is misused and abused by inhalation for its euphorigenic effects. Toluene's reinforcing properties may share a common characteristic with other drugs of abuse, namely, activation of the mesolimbic dopamine system. Prior studies in our laboratory...

journal_title：Annals of the New York Academy of Sciences

authors： Riegel AC,Ali SF,Torinese S,French ED

更新日期：2004-10-01 00:00:00

abstract：:We describe several algorithms with winning performance in the Dialogue for Reverse Engineering Assessments and Methods (DREAM2) Reverse Engineering Competition 2007. After the gold standards for the challenges were released, the performance of the algorithms could be thoroughly evaluated under different parameters or...

journal_title：Annals of the New York Academy of Sciences

authors： Scheinine A,Mentzen WI,Fotia G,Pieroni E,Maggio F,Mancosu G,de la Fuente A

更新日期：2009-03-01 00:00:00

abstract：:Experiments with enzymes in situ that are dependent on ascorbic acid for maximum activity will provide critical information about ascorbic acid requirements. Our work with chromaffin tissue as a model system eventually will result in the determination of two dose-response curves for norepinephrine biosynthesis, repres...

journal_title：Annals of the New York Academy of Sciences

authors： Levine M,Hartzell W

更新日期：1987-01-01 00:00:00

abstract：:Agonist interactions with release processes do not validate autoreceptor operation. Instead, the data suggests that autoreceptors function as homoreceptors. Declining efficacy of agonist inhibition of transmitter release with increasing stimulation "intensity" is not assignable to competition with endogenous transmitt...

journal_title：Annals of the New York Academy of Sciences

authors： Kalsner S

更新日期：1990-01-01 00:00:00

abstract：:Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex signal risk mostly separately from value. Comparable risk signals in...

journal_title：Annals of the New York Academy of Sciences

authors： Schultz W,O'Neill M,Tobler PN,Kobayashi S

更新日期：2011-12-01 00:00:00

abstract：:Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

journal_title：Annals of the New York Academy of Sciences

authors： Takashima A,Mummert M,Kitajima T,Matsue H

更新日期：2000-01-01 00:00:00

abstract：:In amphibians, alpha-MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, th...

journal_title：Annals of the New York Academy of Sciences

authors： Vaudry H,Chartrel N,Desrues L,Galas L,Kikuyama S,Mor A,Nicolas P,Tonon MC

更新日期：1999-10-20 00:00:00

abstract：:Osteoarthritis (OA) is a major source of pain and disability worldwide with no effective medical therapy due to poor understanding of its pathogenesis. Transforming growth factor β (TGF-β) has been reported to play a role in subchondral bone pathology and articular cartilage degeneration during the progression of OA. ...

journal_title：Annals of the New York Academy of Sciences

authors： Xie L,Tintani F,Wang X,Li F,Zhen G,Qiu T,Wan M,Crane J,Chen Q,Cao X

更新日期：2016-07-01 00:00:00

abstract：:Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a ...

journal_title：Annals of the New York Academy of Sciences

authors： Dale-Nagle EA,Hoffman MS,MacFarlane PM,Satriotomo I,Lovett-Barr MR,Vinit S,Mitchell GS

更新日期：2010-06-01 00:00:00

abstract：:Hypomethylation signifies one end of a spectrum of DNA methylation states. In most cases hypomethylation refers to a relative state that represents a change from the "normal" methylation level. Hypomethylation, when approached from a topographical perspective, has been used to describe either overall decreases in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Dunn BK

更新日期：2003-03-01 00:00:00

abstract：:B lymphocytes contribute to the pathogenesis of autoimmune disorders since B-cell depletion treatment improves such diseases. However, B cells seem ambivalent. Murine strains of nonorgan-specific as well as organ-specific autoimmune conditions present with aggravated symptoms when B cells are depleted. It is thus like...

journal_title：Annals of the New York Academy of Sciences

authors： Lemoine S,Morva A,Youinou P,Jamin C

更新日期：2009-09-01 00:00:00

abstract：:The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective trea...

journal_title：Annals of the New York Academy of Sciences

authors： Leigh RJ,Das VE,Seidman SH

更新日期：2002-04-01 00:00:00

abstract：:Collagen VI is a large, disulfide-bonded protein complex which is widely distributed in connective tissue. The constituent polypeptide chains (Mr = 110,000-140,000) consist of collagenous and noncollagenous segments, are degraded to chains of about half the size when collagen VI is solubilized by pepsin, and assemble ...

journal_title：Annals of the New York Academy of Sciences

authors： Engel J,Furthmayr H,Odermatt E,von der Mark H,Aumailley M,Fleischmajer R,Timpl R

更新日期：1985-01-01 00:00:00

abstract：:Results from two similar experimental systems that attempt to create laboratory geophysical analogs in spherical geometry are presented. In the first system, real time holographic interferometry and shadowgraph visualization are used to study convection in the fluid between two concentric spheres when two distinct buo...

journal_title：Annals of the New York Academy of Sciences

authors： Hegseth J,Amara K

更新日期：2002-10-01 00:00:00

abstract：:To test the utility of the UCLA posttraumatic stress disorder (PTSD) Index for DSM-IV (U-PTSD-I)(c) for predicting PTSD diagnosis in children with and without medical illnesses. The U-PTSD-I and a standard psychiatric interview were administered to medically ill children (n = 76) and children who experienced other tra...

journal_title：Annals of the New York Academy of Sciences

authors： Shemesh E,Annunziato RA,Newcorn JH,Rockmore L,Bierer LM,Cohen JA,Schmeidler J,Yehuda R

更新日期：2006-07-01 00:00:00