Abstract:
:The repeated, intermittent use of cocaine and other drugs of abuse produces profound and often long-lasting alterations in behavior and brain chemistry. It has been suggested that these consequences of drug use play a critical role in drug craving and relapse to addiction. This article reviews the effects of psychostimulant administration on dopaminergic and excitatory amino acid neurotransmission in brain regions comprising the brain's motive circuit and provides evidence that the activation of endogenous kappa-opioid receptor systems in these regions opposes the behavioral and neurochemical consequences of repeated drug use. The role of this opioid system in mediating alterations in mood and affect that occur during abstinence from repeated psychostimulant use are also discussed.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Shippenberg TS,Chefer VI,Zapata A,Heidbreder CAdoi
10.1111/j.1749-6632.2001.tb03558.xsubject
Has Abstractpub_date
2001-06-01 00:00:00pages
50-73eissn
0077-8923issn
1749-6632journal_volume
937pub_type
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