Oncogenes and phosphatidylinositol turnover.

abstract：:Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions. It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions. For example, the hypercortisolemia observed in a subset of patients with depression may hav...

journal_title：Annals of the New York Academy of Sciences

authors： Wolkowitz OM,Burke H,Epel ES,Reus VI

更新日期：2009-10-01 00:00:00

abstract：:There are several lines of evidence implying the involvement of the central glutamatergic system in morphine dependence. Extracellular glutamate released from nerve terminals is counterbalanced by glutamate transporters in neurons (EAAC1 and EAAT4) and glial cells (GLT-1 and GLAST), thereby modulating the glutamatergi...

journal_title：Annals of the New York Academy of Sciences

authors： Nakagawa T,Satoh M

更新日期：2004-10-01 00:00:00

abstract：:We have successfully expressed the active tyrosinase of Streptomyces antibioticus in Escherichia coli under the control of the trp promoter by fusing the sequence to the ORF438 gene. Because our attempt to connect the polycistronic gene of ORF438 and tyrosinase directly to the trp promoter of E. coli resulted in the e...

journal_title：Annals of the New York Academy of Sciences

authors： Han K,Hong J,Lim HC,Kim CH,Park Y,Cho JM

更新日期：1994-05-02 00:00:00

abstract：:In the study reported in this paper, we characterized PACAP in the human fetal adrenal gland and we investigated the effect of PACAP on steroid secretion from cultured fetal adrenal cells. The adrenal gland from 20-week-old fetuses contained substantial concentrations of PACAP-immunoreactive material (88.6 ng/g wet ti...

journal_title：Annals of the New York Academy of Sciences

authors： Breault L,Yon L,Montéro M,Chouinard L,Contesse V,Delarue C,Fournier A,Lehoux JG,Vaudry H,Gallo-Payet N

更新日期：2000-01-01 00:00:00

abstract：:The hyperactivation of glutamate receptors, especially those of the N-methyl-d-aspartate subtype (NMDA), can induce excess calcium entry into cells, leading to neuronal death. Since the anesthetic gas xenon behaves as an NMDA antagonist, the present article investigated, by distinct morphological approaches and after ...

journal_title：Annals of the New York Academy of Sciences

authors： Natale G,Cattano D,Abramo A,Forfori F,Fulceri F,Fornai F,Paparelli A,Giunta F

更新日期：2006-08-01 00:00:00

abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...

journal_title：Annals of the New York Academy of Sciences

authors： Schiff ND

更新日期：2009-03-01 00:00:00

abstract：:Legally, women, Native Americans, and African-Americans were defined by the American Constitution as inferior. The pragmatists gradually showed that all selves are equal. These ideas helped the minorities to attain nearly full legal status. But economic status is going in the other direction, toward inequality. It thr...

journal_title：Annals of the New York Academy of Sciences

authors： Wiley N

更新日期：2011-10-01 00:00:00

abstract：:Rocky Mountain spotted fever (RMSF) caused by Rickettsia rickettsii is a severe rickettsiosis that occurs in nearly every state of the continental USA. RMSF is endemic in Central and Southern America, with recent well-documented cases in Mexico, Costa Rica, Panama, Colombia, Brazil, and Argentina. RMSF is the most mal...

journal_title：Annals of the New York Academy of Sciences

authors： Eremeeva ME,Dasch GA

更新日期：2009-05-01 00:00:00

abstract：:In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread ...

journal_title：Annals of the New York Academy of Sciences

authors： Granger DA,Kivlighan KT,el-Sheikh M,Gordis EB,Stroud LR

更新日期：2007-03-01 00:00:00

abstract：:This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

journal_title：Annals of the New York Academy of Sciences

authors： Azimov D,Bishop R

更新日期：2005-12-01 00:00:00

abstract：:A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

journal_title：Annals of the New York Academy of Sciences

authors： Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

更新日期：1993-06-23 00:00:00

abstract：:Landesberg and Sideman's four state model of the cardiac cross-bridge (XB) hypothesizes a feedback of force development to Ca(2+) binding by troponin C (TnC). We have further modeled this behavior and observed that the force (F)-Ca(2+) relationship as well as the F-sarcomere length (SL) relationship and the time cours...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Wakayama Y,Miura M,Stuyvers BD,Boyden PA,Landesberg A

更新日期：2005-06-01 00:00:00

abstract：:We reevaluated the exchange stoichiometry of the Na(+)/Ca(2+) exchange current by measuring its reversal potential. The exchange current was measured from the inside-out macropatch excised from intact sarcolemma of guinea pig ventricular myocytes. This method provides more accurate control of extracellular and cytopla...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuoka S

更新日期：2002-11-01 00:00:00

abstract：:In the early 1970s carbohydrates (CHOs) were believed to induce overconsumption and excess fat deposition. They are now perceived to protect against these consequences. This paper evaluates the evidence for this change of interpretation by considering (1) the energy content of CHOs, (2) the energetic efficiency with w...

journal_title：Annals of the New York Academy of Sciences

authors： Stubbs RJ,Prentice AM,James WP

更新日期：1997-05-23 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:Fibrinogen has been the plasma protein most frequently studied after tissue injury. This report presents evidence that leukocytic endogenous mediator (LEM) from macrophages promotes fibrinogen synthesis. LEM has a molecular weight of 13,000-16,000, an isoelectric point (pI) at pH 7.3, is heat labile, and is inactivate...

journal_title：Annals of the New York Academy of Sciences

authors： Kampschmidt RF,Upchurch HF,Pulliam LA

更新日期：1982-01-01 00:00:00

abstract：:1. One can accurately predict the contribution of each inhibitor to the total inactivation of an enzyme in plasma once its pseudo-first-order reaction rate constant and concentration are known. 2. Because the mechanism of augmentation of the inactivation rate of an enzyme by ATIII occurs via formation of an ATIII-hepa...

journal_title：Annals of the New York Academy of Sciences

authors： Colman RW,Scott CF,Pixley RA,de la Cadena RA

更新日期：1989-01-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:This chapter discusses the influence of drama in the author's background in conceptualizing psychoanalytic theory and practice. The history of ideas relevant to a dramaturgical analysis from Freud to Kohut's revolution, with additional modifications by relational psychoanalysis, is explored. The author poses a trimoda...

journal_title：Annals of the New York Academy of Sciences

authors： Ringstrom PA

更新日期：2009-04-01 00:00:00

abstract：:Content differentiation models posit that different areas of the prefrontal cortex perform similar operations but differ in terms of the content that is operated on. For example, it has been suggested that the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC) perform similar working memory or i...

journal_title：Annals of the New York Academy of Sciences

authors： Zald DH

更新日期：2007-12-01 00:00:00

abstract：:McCune-Albright syndrome (MAS) is caused by postzygotic somatic activating mutations of GNAS and is classically characterized by the clinical triad of peripheral precocious puberty, café-au-lait pigmentation, and polyostotic fibrous dysplasia. It can also present with other hyperfunctioning endocrinopathies, including...

journal_title：Annals of the New York Academy of Sciences

authors： Chatty P,Khattab A,Marshall I

更新日期：2020-03-01 00:00:00

abstract：:Experimental data together with clinical studies have generated information about the association between sympathetic nervous system activity and immunity as measured by in vitro correlates of cellular immune function. In addition, studies on the in vivo role of central CRF in coordinating sympathetic outflow and modu...

journal_title：Annals of the New York Academy of Sciences

authors： Irwin M

更新日期：1993-10-29 00:00:00

abstract：:Potato products contain high amounts of acrylamide, which sometimes exceeds the concentration of 1 mg/L. However, many strategies for acrylamide reduction in potato products are possible. In this work, the different approaches for reducing acrylamide formation have been reviewed, keeping in mind that in the applicatio...

journal_title：Annals of the New York Academy of Sciences

authors： Morales F,Capuano E,Fogliano V

更新日期：2008-04-01 00:00:00

abstract：:Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7...

journal_title：Annals of the New York Academy of Sciences

authors： Scott DJ,Layfield S,Riesewijk A,Morita H,Tregear GW,Bathgate RA

更新日期：2005-05-01 00:00:00

abstract：:Hantaviruses belong to the Bunyaviridae family. While usually hosted by wild mammals, they are potentially pathogenic for humans, and several serologically distinct groups associated with different syndromes have been identified. Yet, investigations have mostly been conducted where human infections by hantaviruses con...

journal_title：Annals of the New York Academy of Sciences

authors： Henttonen H,Buchy P,Suputtamongkol Y,Jittapalapong S,Herbreteau V,Laakkonen J,Chaval Y,Galan M,Dobigny G,Charbonnel N,Michaux J,Cosson JF,Morand S,Hugot JP

更新日期：2008-12-01 00:00:00

abstract：:The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and no...

journal_title：Annals of the New York Academy of Sciences

authors： Cai D,Liu T

更新日期：2011-12-01 00:00:00

abstract：:Developmental robustness, the capacity to stay "on track" despite the myriad vicissitudes that inevitably plague a developing organism, is, I argue, a prerequisite for natural selection and key to our understanding of the evolution of developmental processes. But how is such robustness achieved? And how can we reconci...

journal_title：Annals of the New York Academy of Sciences

authors： Keller EF

更新日期：2002-12-01 00:00:00

abstract：:Hyperprolactinemia is often observed in lymphocytic hypophysitis (LYH). To clarify the possible autoimmune pituitary involvement in patients with apparently idiopathic hyperprolactinemia we investigated the presence of antipituitary antibodies (APA) in hyperprolactinemic patients with idiopathic hyperprolactinemia and...

journal_title：Annals of the New York Academy of Sciences

authors： De Bellis A,Colao A,Pivonello R,Savoia A,Battaglia M,Ruocco G,Tirelli G,Lombardi G,Bellastella A,Bizzarro A

更新日期：2007-06-01 00:00:00

abstract：:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

journal_title：Annals of the New York Academy of Sciences

authors： Heinemann U,Schmitz D,Eder C,Gloveli T

更新日期：2000-06-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of typ...

journal_title：Annals of the New York Academy of Sciences

authors： Lande R,Gilliet M

更新日期：2010-01-01 00:00:00