Antipituitary antibodies in idiopathic hyperprolactinemic patients.

Abstract:

:Hyperprolactinemia is often observed in lymphocytic hypophysitis (LYH). To clarify the possible autoimmune pituitary involvement in patients with apparently idiopathic hyperprolactinemia we investigated the presence of antipituitary antibodies (APA) in hyperprolactinemic patients with idiopathic hyperprolactinemia and in those with prolactinoma. Sixty-six hyperprolactinemic patients (52 F, 14 M age range 28-42 years, group 1) were studied. Of them, 34 out of 66 showed clinical features of hyperprolactinemia and subsequently underwent cabergoline therapy; the 32 out of 66 patients without symptoms of hyperprolactinemia did not receive cabergoline therapy. Moreover, 32 patients (24 F/8M, age range 23-44 years) with hyperprolactinemia due to microprolactinoma (group 2) were also studied. APA, by immunofluorescence method, and anterior pituitary function were evaluated in both groups of patients. APA were present in 17 out of 66 (25.7%) patients in group 1 with titers ranging from 1/16 to 1/64. All patients of group 2 were considered APA negative because these antibodies were found at low titer (

journal_name

Ann N Y Acad Sci

authors

De Bellis A,Colao A,Pivonello R,Savoia A,Battaglia M,Ruocco G,Tirelli G,Lombardi G,Bellastella A,Bizzarro A

doi

10.1196/annals.1381.014

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

129-35

eissn

0077-8923

issn

1749-6632

pii

1107/1/129

journal_volume

1107

pub_type

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