Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle.

abstract：:Language and music are human universals involving perceptually discrete elements organized in hierarchically structured sequences. The set of principles governing the combination of these structural elements into sequences is known as syntax. A violation of expectancies concerning syntactic regularities may be reflect...

journal_title：Annals of the New York Academy of Sciences

authors： Jentschke S,Koelsch S,Friederici AD

更新日期：2005-12-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data. This includes a tremendous quantity of sequence data (e.g., biological structures, genetic and physical maps, pathways) generated by genome and transcriptome projects focused on humans, mice, and a multitude of other species. Diabetes resear...

journal_title：Annals of the New York Academy of Sciences

authors： Petrovsky N,Silva D

更新日期：2004-12-01 00:00:00

abstract：:Intentional exposures to toxic chemicals can stem from terrorist attacks, such as the release of sarin in the Tokyo subway system in 1995, as well as from toxic industrial accidents that are much more common. Developing effective medical interventions is a critical component of the overall strategy to overcome the cha...

journal_title：Annals of the New York Academy of Sciences

authors： Jett DA

更新日期：2016-06-01 00:00:00

abstract：:Insulin receptor isoform A (IR-A) is a fetal insulin receptor isoform that is overexpressed in cancer. We investigated whether insulin-like growth factor (IGF)-II may elicit a different gene expression response from insulin in cells expressing only IR-A and lacking IGF-I receptor (R-/IR-A cells). Cells were stimulated...

journal_title：Annals of the New York Academy of Sciences

authors： Pandini G,Conte E,Medico E,Sciacca L,Vigneri R,Belfiore A

更新日期：2004-12-01 00:00:00

abstract：:Left ventricular (LV) wall motion abnormalities reflect regional nonuniform contraction which may be arrhythmogenic. We studied sarcomere mechanics and force development (F) in uniform and nonuniform trabeculae using a model in which half of the muscle can be rendered weak by exposure to low [Ca2+]o. Stretch allowed t...

journal_title：Annals of the New York Academy of Sciences

authors： ter Keurs HE,Diao N,Deis NP

更新日期：2010-02-01 00:00:00

abstract：:This paper reports preliminary results for pool film boiling on a wire immersed in almost saturated FC72 recently obtained during an experimental campaign performed in low gravity on the European Space Agency Zero-G airplane, (reduced gravity level 10(-2)). This is part of a long-term research program on the effect of...

journal_title：Annals of the New York Academy of Sciences

authors： Di Marco P,Grassi W,Trentavizi F

更新日期：2002-10-01 00:00:00

abstract：:We have earlier shown that monkeys reared with daily alternating monocular occlusion for the first few months of life develop large horizontal strabismus, A/V patterns, dissociated vertical deviation (DVD), and dissociated horizontal deviation (DHD). Here, we present results from neurophysiological experiments that sh...

journal_title：Annals of the New York Academy of Sciences

authors： Das VE

更新日期：2011-09-01 00:00:00

abstract：:Adherent-cell-depleted primed rabbit splenocytes were capable of mounting an in vitro response to SRBC. The addition of alveolar macrophages (AM) to adherent-cell-depleted or unseparated lymphoid cell populations resulted in significant suppression of the PFC response. Suppressive activity was limited to AM and depend...

journal_title：Annals of the New York Academy of Sciences

authors： Herscowitz HB,Pennline KJ,Conrad RE,Ullrich SE,Gerber HR

更新日期：1979-01-01 00:00:00

abstract：:The Women's Health Initiative (WHI) hormone trials have been widely interpreted as demonstrating that combined menopausal hormone therapy (HT) fails to protect against-and may increase-cardiovascular disease (CVD), stroke, and dementia in menopausal women, regardless of whether initiated early in the menopause or late...

journal_title：Annals of the New York Academy of Sciences

authors： Harman SM,Naftolin F,Brinton EA,Judelson DR

更新日期：2005-06-01 00:00:00

abstract：:The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases. These reactive species form through a large number of physiological and non-physiological reactions. An increase in the rate of their prod...

journal_title：Annals of the New York Academy of Sciences

authors： Stadtman ER,Levine RL

更新日期：2000-01-01 00:00:00

abstract：:Although many authors have considered a direct interaction between allergic reactions and behavioral changes, supporting evidence has been elusive. In this series of studies we show that after oral or nasal ovalbumin (OVA) challenge, allergic mice present increased Fos expression in the paraventricular nucleus of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Costa-Pinto FA,Basso AS,De Sá-Rocha LC,Britto LR,Russo M,Palermo-Neto J

更新日期：2006-11-01 00:00:00

abstract：:Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds induce status epilepticus (SE) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. Animal models of orga...

journal_title：Annals of the New York Academy of Sciences

authors： McCarren HS,McDonough JH Jr

更新日期：2016-06-01 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

journal_title：Annals of the New York Academy of Sciences

authors： Slifka MK,Ahmed R

更新日期：1996-10-25 00:00:00

abstract：:The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors. Hepatic ade...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Soresi M,La Spada E,Cervello M,D'Alessandro N,Montalto G

更新日期：2006-11-01 00:00:00

abstract：:Recognizing the self-activity of matter through complexification can lead to seeing evolution as a process of union. This process approach emphasizes a metaphysics of becoming rather than of being. Advances in the science of thermodynamics lead to understanding chemical self-organization as a stage in this process of ...

journal_title：Annals of the New York Academy of Sciences

authors： Salmon JF

更新日期：2003-05-01 00:00:00

abstract：:This publication provides a brief summary of a presentation given at the NICHD Anniversary Symposium that was designed to describe the research progress of the O'Malley laboratory over the past 30 years of its NICHD funding. It highlights a few of the lab's major discoveries during the course of the pursuit of its lon...

journal_title：Annals of the New York Academy of Sciences

authors： O'Malley BW

更新日期：2004-12-01 00:00:00

abstract：:Relaxin (RLX) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor gamma (PPARgamma), raising the possibility that a mechanism for RLX's antifibrotic effects may involve activation of the PPARgamma pathway. T...

journal_title：Annals of the New York Academy of Sciences

authors： Singh S,Bennett RG

更新日期：2009-04-01 00:00:00

abstract：:Glycoxidation and lipoxidation reactions contribute to the chemical modification of proteins during the Maillard reaction. Reactive oxygen species, produced during the oxidation of sugars and lipids in these processes, irreversibly oxidize proteins. Methionine is particularly susceptible to oxidation, yielding the oxi...

journal_title：Annals of the New York Academy of Sciences

authors： Brock JW,Cotham WC,Ames JM,Thorpe SR,Baynes JW

更新日期：2005-06-01 00:00:00

abstract：:Modest changes in gene expression of three-fold or less might be expected after mild to moderate neurotoxic exposure to classes of compounds, such as the substituted amphetamines, or at time points that are weeks after more severe neurotoxic exposures. When many genes appear to change expression by less than two-fold,...

journal_title：Annals of the New York Academy of Sciences

authors： Delongchamp RR,Harris AJ,Bowyer JF

更新日期：2003-05-01 00:00:00

abstract：:Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...

journal_title：Annals of the New York Academy of Sciences

authors： Graybill JR,Stevens DA,Galgiani JN,Sugar AM,Craven PC,Gregg C,Huppert M,Cloud G,Dismukes WE

更新日期：1988-01-01 00:00:00

abstract：:The lobster stomatogastric ganglion contains 30 neurons and when modulated can produce two distinct rhythmic motor patterns--the gastric mill and the pyloric. The complete neural circuitry underlying both patterns is well known. Without modulatory input no patterns are produced, and the neurons fire tonically or are s...

journal_title：Annals of the New York Academy of Sciences

authors： Selverston A,Elson R,Rabinovich M,Huerta R,Abarbanel H

更新日期：1998-11-16 00:00:00

abstract：:For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the in vitro combination of elements judged necessary for in vivo impla...

journal_title：Annals of the New York Academy of Sciences

authors： Arakelian L,Kanai N,Dua K,Durand M,Cattan P,Ohki T

更新日期：2018-12-01 00:00:00

abstract：:Using the Diagrammatic Cell Language trade mark, Gene Network Sciences (GNS) has created a network model of interconnected signal transduction pathways and gene expression networks that control human cell proliferation and apoptosis. It includes receptor activation and mitogenic signaling, initiation of cell cycle, an...

journal_title：Annals of the New York Academy of Sciences

authors： Christopher R,Dhiman A,Fox J,Gendelman R,Haberitcher T,Kagle D,Spizz G,Khalil IG,Hill C

更新日期：2004-05-01 00:00:00

abstract：:The following study describes the basic demography of colorectal cancer patients and characteristics of the disease seen at a regional tertiary care cancer hospital. The study highlights the influence of gender and age on the occurrence of this malignancy in patients in Pakistan. In general, this population shares man...

journal_title：Annals of the New York Academy of Sciences

authors： Anwar N,Badar F,Yusuf MA

更新日期：2008-09-01 00:00:00

abstract：:Many studies have now indicated that micronutrients, such as the carotenoids, tocopherols, and ascorbic acid, can prevent mutagenesis, genotoxic effects, or malignant transformation in bacteria and mammalian tissue, either in cell culture or in organ culture. In addition, multiple papers report that some of these micr...

journal_title：Annals of the New York Academy of Sciences

authors： Krinsky NI

更新日期：1993-05-28 00:00:00

abstract：:The effect of 310 courses of corticotropin, methylprednisolone, prednisone, and dexamethasone were studied in 62 patients with generalized myasthenia gravis who were poorly responsive to anticholinesterase medication and most of whom required assisted respiration. Improvement in strength and response to anticholinest...

journal_title：Annals of the New York Academy of Sciences

authors： Brunner NG,Berger CL,Namba T,Grob D

更新日期：1976-01-01 00:00:00

abstract：:It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

journal_title：Annals of the New York Academy of Sciences

authors： Kamihira M,Yamada K,Hamamoto R,Iijima S

更新日期：1997-12-31 00:00:00

abstract：:Calcium-dependent activator protein for secretion (CAPS) was initially identified in brain cytosol based on its ability to reconstitute calcium-triggered dense-core vesicle (DCV) exocytosis in permeable cell lines (PC12) of adrenal chromaffin origin. Current evidence indicates that CAPS functions selectively in DCV ex...

journal_title：Annals of the New York Academy of Sciences

authors： Wassenberg JJ,Martin TF

更新日期：2002-10-01 00:00:00

abstract：:Thromboembolic and infectious events were found to be major complications of long-term total artificial heart implantation in two patients. Similar complications have been reported in other patients, as well as in animal studies. The thromboembolic events and the infectious complications appear to be interrelated. On ...

journal_title：Annals of the New York Academy of Sciences

authors： Ward RA,Wellhausen SR,Dobbins JJ,Johnson GS,DeVries WC

更新日期：1987-01-01 00:00:00