Abstract:
:The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3-month dietary vitamin E restriction to 25% of recommended intake and 2-month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20-75-year-old volunteers. Significant changes in vitamin E status were associated with decreases and increases, respectively, in LDL resistance to oxidation in the depletion and supplementation period and with decreases in lipid peroxidation and oxidative DNA modification in the supplementation period. Healthy aging was not associated with enhanced susceptibility to oxidation in the depletion period.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Winklhofer-Roob BM,Meinitzer A,Maritschnegg M,Roob JM,Khoschsorur G,Ribalta J,Sundl I,Wuga S,Wonisch W,Tiran B,Rock E,VITAGE Study Group.doi
10.1196/annals.1331.045subject
Has Abstractpub_date
2004-12-01 00:00:00pages
361-4eissn
0077-8923issn
1749-6632pii
1031/1/361journal_volume
1031pub_type
杂志文章abstract::Based on the relation found to exist between low CSF 5-HIAA and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-HT metabolism is related to (auto)aggression, rather than to depression. We chall...
journal_title:Annals of the New York Academy of Sciences
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