Characterization of the mouse and rat relaxin receptors.

Abstract:

:Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7 homologous sequences from mouse and rat were discovered in the Celera and NCBI gene databases, amplified, cloned, and sequenced. At the protein level, mouse and rat LGR7 are 85.2% and 85.7% identical to human LGR7. Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands.

journal_name

Ann N Y Acad Sci

authors

Scott DJ,Layfield S,Riesewijk A,Morita H,Tregear GW,Bathgate RA

doi

10.1196/annals.1282.002

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

8-12

eissn

0077-8923

issn

1749-6632

pii

1041/1/8

journal_volume

1041

pub_type

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