Proteomic technologies to study diseases of the lymphatic vascular system.

abstract：:We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

journal_title：Annals of the New York Academy of Sciences

authors： Hixson JE,Blangero J

更新日期：2000-05-01 00:00:00

abstract：:Sleep deprivation severely compromises the ability of human beings to respond to stimuli in a timely fashion. These deficits have been attributed in large part to failures of vigilant attention, which many theorists believe forms the bedrock of the other more complex components of cognition. One of the leading paradig...

journal_title：Annals of the New York Academy of Sciences

authors： Lim J,Dinges DF

更新日期：2008-01-01 00:00:00

abstract：:Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

journal_title：Annals of the New York Academy of Sciences

authors： Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

更新日期：2019-01-01 00:00:00

abstract：:Tolerance has been defined as a lack of response to self but a more appropriate definition of tolerance is "any mechanism by which a potentially injurious immune response is prevented, suppressed, or shifted to a non-injurious class of immune response." Thus, tolerance is related to productive self-recognition, rather...

journal_title：Annals of the New York Academy of Sciences

authors： Weiner HL

更新日期：2004-12-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have an increased incidence of vascular disease, and oxidative stress is recognized as an important feature in this condition, despite the underlying mechanisms not being fully understood. In these patients, an interaction between lipoproteins and the immune system has ...

journal_title：Annals of the New York Academy of Sciences

authors： Batuca JR,Ames PR,Isenberg DA,Alves JD

更新日期：2007-06-01 00:00:00

abstract：:Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders that cause individuals to be prone to a variety of clinical manifestations, such as infections, autoimmunity, and malignancies. Early diagnosis and adequate treatment of these disorders can reduce morbidity and mortality and prov...

journal_title：Annals of the New York Academy of Sciences

authors： Rezaei N,Mohammadinejad P,Aghamohammadi A

更新日期：2011-11-01 00:00:00

abstract：:Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

journal_title：Annals of the New York Academy of Sciences

authors： Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

更新日期：1983-06-27 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:In most countries, tuberculosis caused by Mycobacterium bovis is mainly a disease of domestic cattle and can be controlled successfully by means of a test-and-slaughter program. Once the infection spills over into a wild animal species with maintenance host potential, conventional measures are no longer sufficient to ...

journal_title：Annals of the New York Academy of Sciences

authors： Michel AL

更新日期：2002-10-01 00:00:00

abstract：:Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bon...

journal_title：Annals of the New York Academy of Sciences

authors： Zhu J,Liu C,Jia J,Zhang C,Yuan W,Leng H,Xu Y,Song C

更新日期：2020-08-01 00:00:00

abstract：:New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL...

journal_title：Annals of the New York Academy of Sciences

authors： Paré D,Royer S,Smith Y,Lang EJ

更新日期：2003-04-01 00:00:00

abstract：:In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

journal_title：Annals of the New York Academy of Sciences

authors： Larsson M,Bäckman L

更新日期：1998-11-30 00:00:00

abstract：:Insulin-related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea, were purified and characterized (IRP1-IRP13) using insulin and insulin-like growth factor-I (IGF-I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF-I receptors. Dose-dependent curve slopes indicated that most IRPs bin...

journal_title：Annals of the New York Academy of Sciences

authors： Shipilov VN,Shpakov AO,Rusakov YI

更新日期：2005-04-01 00:00:00

abstract：:Clinicians use the combination of Tanner stage 5 (T5) of puberty, final height, and epiphyseal fusion to define maturity. We tested the hypothesis that changes in body composition related to age are identifiable during T5. Asian, Black, Hispanic, and White T5 adolescents (n = 148, 72 females) had measurements taken of...

journal_title：Annals of the New York Academy of Sciences

authors： Horlick M,Thornton J,Wang J,Levine LS,Fedun B,Pierson RN Jr

更新日期：2000-05-01 00:00:00

abstract：:Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical research. It encompasses new treatments, advanced equipment, medical procedures, preventive and diagnostic approaches creating a bridge between basic studies and clinica...

journal_title：Annals of the New York Academy of Sciences

authors： Amirmahani F,Ebrahimi N,Molaei F,Faghihkhorasani F,Jamshidi Goharrizi K,Mirtaghi SM,Borjian-Boroujeni M,Hamblin MR

更新日期：2021-01-06 00:00:00

abstract：:The current trend in antipoverty policy emphasizes mandated empowerment: the poor are being handed the responsibility for making things better for themselves, largely without being asked whether this is what they want. Beneficiary control is now being built into public service delivery, while microcredit and small bus...

journal_title：Annals of the New York Academy of Sciences

authors： Banerjee AV,Duflo E

更新日期：2008-01-01 00:00:00

abstract：:While there has been substantial growth in early childhood development (ECD) services in low- and middle-income countries (LMICs), there is considerable inequity in their distribution and quality. Evidence-based governance strategies are necessary, but currently they are insufficient for widespread, quality implementa...

journal_title：Annals of the New York Academy of Sciences

authors： Britto PR,Yoshikawa H,van Ravens J,Ponguta LA,Reyes M,Oh S,Dimaya R,Nieto AM,Seder R

更新日期：2014-01-01 00:00:00

abstract：:The hyperactivation of glutamate receptors, especially those of the N-methyl-d-aspartate subtype (NMDA), can induce excess calcium entry into cells, leading to neuronal death. Since the anesthetic gas xenon behaves as an NMDA antagonist, the present article investigated, by distinct morphological approaches and after ...

journal_title：Annals of the New York Academy of Sciences

authors： Natale G,Cattano D,Abramo A,Forfori F,Fulceri F,Fornai F,Paparelli A,Giunta F

更新日期：2006-08-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a serious, chronic condition that, without early recognition and treatment, leads to progressive right heart failure and death. The dual endothelin receptor antagonist macitentan was designed through a deliberate discovery process to maximize endothelin-axis blockade while impr...

journal_title：Annals of the New York Academy of Sciences

authors： Selej M,Romero AJ,Channick RN,Clozel M

更新日期：2015-11-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:The National Institutes of Health's Clinical and Translational Science Award (CTSA) program has had a profound impact on clinical research and training methods at the University of California, Davis (UC Davis). UC Davis was among the first 12 institutions to receive NIH funding for this award, and created its Clinical...

journal_title：Annals of the New York Academy of Sciences

authors： Kasim-Karakas S,Hyson D,Halsted C,van Loan M,Chedin E,Berglund L

更新日期：2010-03-01 00:00:00

abstract：:Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

journal_title：Annals of the New York Academy of Sciences

authors： Smith CJ,Ajdukiewicz A,Kelleher PC

更新日期：1983-01-01 00:00:00

abstract：:Cellulose degradation is a rare trait in bacteria. However, the truly cellulolytic bacteria are extremely efficient hydrolyzers of plant cell wall polysaccharides, especially those in thermophilic anaerobic ecosystems. Clostridium stercorarium, a thermophilic ubiquitous soil dweller, has a simple cellulose hydrolyzing...

journal_title：Annals of the New York Academy of Sciences

authors： Zverlov VV,Schwarz WH

更新日期：2008-03-01 00:00:00

abstract：:Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

journal_title：Annals of the New York Academy of Sciences

authors： Zetterberg A,Engström W,Larsson O

更新日期：1982-12-10 00:00:00

abstract：:Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

journal_title：Annals of the New York Academy of Sciences

authors： Surh YJ,Lee JY,Choi KJ,Ko SR

更新日期：2002-11-01 00:00:00

abstract：:Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

journal_title：Annals of the New York Academy of Sciences

authors： Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

更新日期：1999-06-22 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:In this chapter, we examine the possibility that negative emotions contribute to the relationship between socioeconomic status (SES) and health. A model of the associations among SES, emotion, and health is presented first. We then review the evidence for this model, showing associations of SES with depression, hopele...

journal_title：Annals of the New York Academy of Sciences

authors： Gallo LC,Matthews KA

更新日期：1999-01-01 00:00:00

abstract：:There is an urgent need for surrogate biomarkers in clinical diagnostics but also preclinical in toxicology of chemicals and efficacy testing of pharmaceuticals. On the background of the emerging fields of systems biology and theranostics, the importance of time scales and the synchronization of complex biological rea...

journal_title：Annals of the New York Academy of Sciences

authors： Schrattenholz A,Soskić V,Groebe K

更新日期：2010-06-01 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00