Current issues in the treatment of human diseases by mucosal tolerance.

abstract：:CYP21A2 genotyping remains an important element in the diagnosis and management of congenital adrenal hyperplasia, and establishing accurate genotype-phenotype correlations has facillitated adequate genetic counseling and prenatal management for at-risk families. Despite extensive efforts to establish a clear genotype...

journal_title：Annals of the New York Academy of Sciences

authors： Elmougy F,Sharaf S,Hafez M,Khattab A,Abou-Yousef H,Elsharkawy M,Baz H,Ekladious S,Sherif B,Musa N,Elshiwy Y,Afif A,Abdullatif M,Thabet G,Rady N,Ibrahim A,Soliman H

更新日期：2018-03-01 00:00:00

abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...

journal_title：Annals of the New York Academy of Sciences

authors： Schiff ND

更新日期：2009-03-01 00:00:00

abstract：:After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metasta...

journal_title：Annals of the New York Academy of Sciences

authors： Garaci E,Favalli C,Pica F,Sinibaldi Vallebona P,Palamara AT,Matteucci C,Pierimarchi P,Serafino A,Mastino A,Bistoni F,Romani L,Rasi G

更新日期：2007-09-01 00:00:00

abstract：:Immunosuppressive therapy and clinical evolution were studied in 49 patients (29 females) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The mean age of patients at presentation was 55 years, and the mean (+/-SD) follow-up was 43 months (+/-33) (range, 3-140). Among the 49 patients, 10 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kokolina E,Alexopoulos E,Dimitriadis C,Vainas A,Giamalis P,Papagianni A,Ekonomidou D,Memmos D

更新日期：2005-06-01 00:00:00

abstract：:Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

journal_title：Annals of the New York Academy of Sciences

authors： Hertzman C

更新日期：1999-01-01 00:00:00

abstract：:Hypophysectomy leads to a small increase in tyrosine hydroxylase activity of all brain areas containing noradrenergic neurons or tuberoinfundibular dopamine neurons, but nigroneostriatal dopamine neurons are not so affected. ACTH or corticosterone treatment inhibited this effect of hypophysectomy in some noradrenergic...

journal_title：Annals of the New York Academy of Sciences

authors： Van Loon GR,Sole MJ,Kamble A,Kim C,Green S

更新日期：1977-10-28 00:00:00

abstract：:The present article investigated clinical symptoms and their longitudinal clinical course following pharmacological treatment in 32 female incarcerated patients suffering from methamphetamine (METH) psychosis who were referred to psychiatric consultation. The length of METH-abuse periods of the patients ranged from 2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama K

更新日期：2006-08-01 00:00:00

abstract：:Experimental data together with clinical studies have generated information about the association between sympathetic nervous system activity and immunity as measured by in vitro correlates of cellular immune function. In addition, studies on the in vivo role of central CRF in coordinating sympathetic outflow and modu...

journal_title：Annals of the New York Academy of Sciences

authors： Irwin M

更新日期：1993-10-29 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of neurodegenerative diseases. Specifically, we propose that an imbalanc...

journal_title：Annals of the New York Academy of Sciences

authors： Knott AB,Bossy-Wetzel E

更新日期：2008-12-01 00:00:00

abstract：:The nature and regulation of juvenile hormone (JH) biosynthesis have been investigated in isolated corpora allata (CA) of adult males and females, and larvae of the tomato moth Lacanobia oleracea (Noctuidae). Larval CA (Vth day 1 to VIth day 1) appear to synthesize JH at very low rates (< 0.5 fmol/pr/h). This synthesi...

journal_title：Annals of the New York Academy of Sciences

authors： Audsley N,Weaver RJ,Edwards JP

更新日期：1999-01-01 00:00:00

abstract：:Previous reports have shown that there are age-related reductions in muscarinic receptor (mAChR) sensitivity to agonist stimulation. Our research has elucidated the mechanisms involved in this loss. These studies have shown that this decline is the result of decreases in mAChR concentration, reductions in the number o...

journal_title：Annals of the New York Academy of Sciences

authors： Joseph JA,Cutler R,Roth GS

更新日期：1993-09-24 00:00:00

abstract：:Exposure of LLC-PK1 epithelial cell cultures to phorbol ester tumor promoters causes immediate translocation of protein kinase C-alpha (PKC-alpha) from cytosolic to membrane-associated compartments. With a very similar time course, a dramatic and sustained increase in tight junctional (paracellular) permeability occur...

journal_title：Annals of the New York Academy of Sciences

authors： Mullin JM,Laughlin KV,Ginanni N,Marano CW,Clarke HM,Peralta Soler A

更新日期：2000-01-01 00:00:00

abstract：:During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to ...

journal_title：Annals of the New York Academy of Sciences

authors： Chiba T,Fujita S,Kubota H,Inoue D,Mizuno A,Komatsu T,Yamaza H,Higami Y,Shimokawa I

更新日期：2007-11-01 00:00:00

abstract：:Mitochondrial dysfunction has been suggested as a causal factor for insulin resistance and diabetes. Previously we have shown a decrease of mitochondrial DNA (mtDNA) content in tissues of diabetic patients. The mitochondrial proteins, which regulate the mitochondrial biogensis, including transcription and replication ...

journal_title：Annals of the New York Academy of Sciences

authors： Choi YS,Ryu BK,Min HK,Lee SW,Pak YK

更新日期：2005-05-01 00:00:00

abstract：:To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were amino...

journal_title：Annals of the New York Academy of Sciences

authors： Huang MJ,Regunathan S,Botta M,Lee K,McClendon E,Yi GB,Pedersen ML,Berkowitz DB,Wang G,Travagli M,Piletz JE

更新日期：2003-12-01 00:00:00

abstract：:Phosphomannose isomerase (PMI), an enzyme not present in many plants, catalyzes the reversible interconversion of mannose 6-phosphate and fructose 6-phosphate. Plant cells lacking this enzyme are incapable of surviving on synthetic medium containing mannose. Thus PMI/mannose selection has utility in the identification...

journal_title：Annals of the New York Academy of Sciences

authors： Privalle LS

更新日期：2002-05-01 00:00:00

abstract：:Image processing in fluid mechanics has become an important quantitative tool for flow analysis. The feasibility of simultaneous measurements of instantaneous velocity and temperature fields, as well as for tracking interfaces, creates a functional tool to describe thermally driven flows accompanied by phase change. T...

journal_title：Annals of the New York Academy of Sciences

authors： Kowalewski TA

更新日期：2002-10-01 00:00:00

abstract：:A total of 1,098 serum samples were analyzed against Anaplasma phagocytophilum by immunofluorescent antibody (IFA) test. These serum samples belonged to four different populations distributed throughout two provinces of Galicia (Ourense and Pontevedra) located in northwestern Spain: bovine population (456 samples); ov...

journal_title：Annals of the New York Academy of Sciences

authors： Amusategui I,Sainz A,Tesouro MA

更新日期：2006-10-01 00:00:00

abstract：:Transcriptional profiling and functional genomics experiments using E11.5 metanephros organ cultures from Ahr(-/-) and Ahr(+/+) have shown that aryl hydrocarbon receptor (AHR) transcription factor is involved in the regulation of mesenchymal-to-epithelial transition (MET) during nephrogenesis. This response is mediate...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos KS

更新日期：2006-09-01 00:00:00

abstract：:The implications of recent precision Z-pole, W mass, and weak neutral current data for testing the standard electroweak model, constraining that t quark and Higgs masses, αs (MZ), and grand unification are discussed. A fit to all data yields sin(2)θw(MZ)= 0.2325 ± 0.0024 (on-shell), where the uncertainties are mainly ...

journal_title：Annals of the New York Academy of Sciences

authors： Langacker P

更新日期：1993-06-01 00:00:00

abstract：:The use of animal cells, tissues, or organs for humans is being investigated as an alternative to allotransplantation and as therapy for a broad range of disease states including diabetes, Parkinson's disease, and neurologic pain control. The risk of transmitting novel infections with these tissues, xenozoonoses, has ...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels M

更新日期：1998-12-30 00:00:00

abstract：:Athletic women are at risk for developing ovulatory dysfunction, which presents variably as menstrual irregularity or absence. Initially characterized as an isolated disruption of hypothalamic gonadotropin-releasing hormone (GnRH) release, athletic amenorrhea, a form of hypogonadotropic hypogonadism, is invariably acc...

journal_title：Annals of the New York Academy of Sciences

authors： Pauli SA,Berga SL

更新日期：2010-09-01 00:00:00

abstract：:Our studies to date indicate that treatment with anti-idiotype to monoclonal anti-MHC antibodies can markedly influence the repertoire of anti-MHC antibodies expressed. The antibodies discussed here appear to represent two classes, one of which is public, probably representing expression of a germ line gene, and the s...

journal_title：Annals of the New York Academy of Sciences

authors： Sachs DH,Bluestone JA,Epstein SL,Rabinowitz R

更新日期：1983-01-01 00:00:00

abstract：:This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

journal_title：Annals of the New York Academy of Sciences

authors： Neau L,Pruvost J,Rodriguez O,Loc TP

更新日期：2002-10-01 00:00:00

abstract：:The aim of the present article was to investigate the occurrence and temporary changes of pituitary adenylate cyclase-activating polypeptide (PACAP)-38 and vasoactive intestinal peptide (VIP) in various brain areas of chicken embryos by means of radioimmunoassay. The highest concentrations of PACAP-38 were measured in...

journal_title：Annals of the New York Academy of Sciences

authors： Jozsa R,Hollosy T,Nemeth J,Tamás A,Lubics A,Jakab B,Olah A,Arimura A,Reglödi D

更新日期：2006-07-01 00:00:00

abstract：:In patients with Ménière's disease (MD), caloric testing can show, depending on the stage and activity of the disease, a variety of results. Between attacks, many, or perhaps even most, patients with unilateral early or mild MD have normal caloric tests; late MD can show abnormalities ranging from mild to severe unila...

journal_title：Annals of the New York Academy of Sciences

authors： McGarvie LA,Curthoys IS,MacDougall HG,Halmagyi GM

更新日期：2015-04-01 00:00:00

abstract：:Human germ-cell tumors (GCTs) are a heterogeneous group of neoplasms. Based on epidemiology, anatomical site of presentation, histology, chromosomal constitution, and pattern of genomic imprinting, GCTs are classified into five entities. Within the testis, three types of GCTs can be diagnosed: type I (teratomas and yo...

journal_title：Annals of the New York Academy of Sciences

authors： Looijenga LH,Gillis AJ,Stoop HJ,Hersmus R,Oosterhuis JW

更新日期：2007-12-01 00:00:00

abstract：:Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-indu...

journal_title：Annals of the New York Academy of Sciences

authors： Kanthasamy A,Anantharam V,Ali SF,Kanthasamy AG

更新日期：2006-08-01 00:00:00

abstract：:Compelling evidence now exists for estrogen's involvement in the regulation of mood and cognitive functions. Serum estrogen levels have been shown to play an important role in the expression of psychiatric disorders such as depression and schizophrenia. We have characterized the distribution of the estrogen receptors,...

journal_title：Annals of the New York Academy of Sciences

authors： Ostlund H,Keller E,Hurd YL

更新日期：2003-12-01 00:00:00