Abstract：
:Although tissue injury can evoke significant hyperalgesia in infants from the first days of life, little is known about how injury affects emergent central pain networks at the synaptic level. Recent studies have investigated whether tissue damage at different ages has distinct consequences for synaptic function in the rat superficial dorsal horn (SDH) using in vitro patch clamp recordings from spinal cord slices prepared at different times after an injury. The results demonstrate that tissue damage during the first postnatal week transiently increases the frequency (but not amplitude) of miniature excitatory postsynaptic currents (mEPSCs), while no changes are observed at inhibitory synapses onto the same neurons. Prolonged blockade of sciatic nerve activity in vivo with bupivacaine hydroxide or tetrodotoxin prevented the elevation in mEPSC frequency following early injury. In contrast, tissue damage during the third postnatal week failed to significantly alter spontaneous excitatory or inhibitory synaptic transmission in the SDH. These data show that afferent activity arising from injured peripheral tissue selectively regulates glutamatergic synaptic signaling in the developing SDH in a highly age-dependent manner.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Baccei MLdoi
10.1111/j.1749-6632.2009.05425.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
159-67eissn
0077-8923issn
1749-6632pii
NYAS5425journal_volume
1198pub_type
杂志文章abstract：:Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, an...
journal_title：Annals of the New York Academy of Sciences
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doi：10.1111/j.1749-6632.2002.tb04642.x
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abstract：:Studies on host responses in sheep artificially infected with Theileria sp. (China) were discussed and summarized mainly on typical high fever periods, merozoits and schizoon observation, antibody response. ...
journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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doi：10.1111/j.1749-6632.1999.tb07943.x
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：2008-12-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2006-11-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2003.tb06086.x
更新日期：2003-05-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1998.tb08245.x
更新日期：1998-05-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1985.tb20845.x
更新日期：1985-01-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2000.tb06391.x
更新日期：2000-04-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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doi：10.1111/j.1749-6632.2009.04734.x
更新日期：2009-06-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：1998-10-23 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：
更新日期：1998-06-21 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1996.tb53525.x
更新日期：1996-07-23 00:00:00
abstract：:In South America, human cases of infection by the genus Rickettsia have been described in several countries in the last twenty years. The role of international organizations, such as the Centers for Disease Control and Prevention in Atlanta, Georgia, USA and the World Health Organization Collaborating Center for Tropi...
journal_title：Annals of the New York Academy of Sciences
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更新日期：2003-06-01 00:00:00
abstract：:An extended parallel is developed between musical and prosodic structures, using the author's cognitively oriented music theory and recent work in generative phonology. For illustration, the sounds of a short poem by Robert Frost are treated entirely in musical terms. The poem is assigned a phonological stress grid an...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2001.tb05743.x
更新日期：2001-06-01 00:00:00
abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...
journal_title：Annals of the New York Academy of Sciences
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更新日期：2002-11-01 00:00:00
abstract：:This paper considers issues arising from presentations by Barry Everitt and Gorica Petrovich concerning amygdalar involvement in appetitive conditioning. Studies reported by these researchers are beginning to unravel the distribution of associative functions among amygdalar nuclei and their efferent targets. The main ...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
abstract：:The tick-borne protozoan parasite Theileria annulata causes tropical theileriosis, a severe leukoproliferative disease of cattle, which naive susceptible animals fail to control. The parasite infects and transforms macrophages, developing in the local draining lymph node. IFN gamma has been shown to block parasite dev...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1998.tb11044.x
更新日期：1998-06-29 00:00:00
abstract：:To investigate the role of poliovirus (PV) infection in the development of the post-polio syndrome (PPS), we studied the serum, spinal fluid, peripheral blood lymphocytes, and muscle from 47 patients with PPS. We found high titers of IgM PV antibodies (up to 1:250) in the serum of 6 patients, compared to very low tite...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1995.tb27547.x
更新日期：1995-05-25 00:00:00
abstract：:The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
