Induction of apoptosis by erucylphospho-N,N,N-trimethylammonium is associated with changes in signal molecule expressionand location.

Abstract:

:At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at least part of its antineoplastic activity by apoptosis, and this chain of events comprises early changes in the lipid raft fraction of the cellular membrane as well as modulation of different signal molecules, such as Abl, Bcr-Abl (fusion protein), and Rb.

journal_name

Ann N Y Acad Sci

authors

Berger MR,Tsoneva I,Konstantinov SM,Eibl H

doi

10.1196/annals.1299.054

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

307-10

eissn

0077-8923

issn

1749-6632

journal_volume

1010

pub_type

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