Dietary influences on cognitive function with aging: from high-fat diets to healthful eating.

Abstract:

:Human epidemiologic studies provide convincing evidence that dietary patterns practiced during adulthood are important contributors to age-related cognitive decline and dementia risk. Diets high in fat, especially trans and saturated fats, adversely affect cognition, while those high in fruits, vegetables, cereals, and fish are associated with better cognitive function and lower risk of dementia. While the precise physiologic mechanisms underlying these dietary influences are not completely understood, modulation of brain insulin activity and neuroinflammation likely contribute. Not surprisingly, deficits in cognitive functions, especially those dependent on the medial temporal lobes, are apparent in type 2 diabetes mellitus (T2DM). Special care in food selection at meals should be exercised by those with T2DM since ingestion of rapidly absorbed, high-glycemic index carbohydrate foods further impairs medial temporal lobe function, with food-induced increases in oxidative stress and cytokine release likely explaining the association between food ingestion and reduction in cognitive function in those with T2DM.

journal_name

Ann N Y Acad Sci

authors

Parrott MD,Greenwood CE

doi

10.1196/annals.1396.028

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

389-97

eissn

0077-8923

issn

1749-6632

pii

1114/1/389

journal_volume

1114

pub_type

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