The role of proopiomelanocortin-derived peptides in skin fibroblast and mast cell functions.

abstract：:The definition of polycystic ovary syndrome in very young girls is complicated by the fact that many features typical of the syndrome can also be seen as physiological stages in the maturation of the hypothalamus-pituitary-ovarian axis. The role of reduced insulin sensitivity in the pathogenesis and evolution of the d...

journal_title：Annals of the New York Academy of Sciences

authors： Bruni V,Dei M,Nannini S,Balzi D,Nuvolone D

更新日期：2010-09-01 00:00:00

abstract：:The natural tetrapeptide acetyl-ser-asp-lys-pro (AcSDKP) is formed in vivo by enzymatic cleavage of the N terminus of thymosin beta4 by prolyl oligopeptidase (POP). Recently, AcSDKP was shown to promote angiogenesis. Because of the critical role of neovascularization in cancer development, the levels of AcSDKP and POP...

journal_title：Annals of the New York Academy of Sciences

authors： Liu JM,Garcia-Alvarez MC,Bignon J,Kusinski M,Kuzdak K,Riches A,Wdzieczak-Bakala J

更新日期：2010-04-01 00:00:00

abstract：:Neovascularization is a hallmark of cancer progression. Suppression of the angiogenic response in tumors has been associated with inhibition and even regression of total tumor mass. Therefore, the derivation of synthetic or natural products that could interfere with proangiogenic signaling pathways can greatly impact ...

journal_title：Annals of the New York Academy of Sciences

authors： Iruela-Arispe ML,Carpizo D,Luque A

更新日期：2003-05-01 00:00:00

abstract：:Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

journal_title：Annals of the New York Academy of Sciences

authors： Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

更新日期：2012-06-01 00:00:00

abstract：:After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metasta...

journal_title：Annals of the New York Academy of Sciences

authors： Garaci E,Favalli C,Pica F,Sinibaldi Vallebona P,Palamara AT,Matteucci C,Pierimarchi P,Serafino A,Mastino A,Bistoni F,Romani L,Rasi G

更新日期：2007-09-01 00:00:00

abstract：:Liquid membrane reactors are well known for metal extraction. This technology may also be applied to the immobilization of enzymes in enzyme emulsions. The use of liquid membrane reactors for enzymatic bioconversions has several advantages in comparison to solid membrane reactors and conventional immobilization techni...

journal_title：Annals of the New York Academy of Sciences

authors： Scheper T,Makryaleas K,Nowottny C,Likidis Z,Tsikas D,Schügerl K

更新日期：1987-01-01 00:00:00

abstract：:Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was...

journal_title：Annals of the New York Academy of Sciences

authors： Numachi Y,Yoshida S,Inosaka T,Sato M,Mizugaki M,Kimura K,Hishinuma T

更新日期：1992-06-28 00:00:00

abstract：:This article reviews research on the Finnish model of peer-group mentoring (PGM). The theoretical foundation of the model is based on the constructivist theory of learning, the concept of autonomy in teaching profession, peer learning, and narrative identity work. The model has been disseminated nationwide in the educ...

journal_title：Annals of the New York Academy of Sciences

authors： Tynjälä P,Pennanen M,Markkanen I,Heikkinen HLT

更新日期：2021-01-01 00:00:00

abstract：:Enhancer DNA decoy oligonucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth. We used DNA microarrays to analyze the global gene expression ...

journal_title：Annals of the New York Academy of Sciences

authors： Cho-Chung YS

更新日期：2003-12-01 00:00:00

abstract：:The objective of this article is to investigate the influence of endothelin-1 (ET-1) on human monocyte Na(+)/H(+) exchanger (NHE) activity and on the atherosclerosis-related monocyte functions. ET-1 caused an increase in pHi and in (22)Na influx of monocytes. A reversal of ET-1 effect on pHi was observed in the presen...

journal_title：Annals of the New York Academy of Sciences

authors： Koliakos G,Befani C,Paletas K,Kaloyianni M

更新日期：2007-01-01 00:00:00

abstract：:It has been suggested that obese children have increased problems with self-esteem and depression when compared to the normal pediatric population. Fifty-one consecutive patients enrolled in a hospital based weight management program received the CDI and the PHSCS as part of their initial evaluation. There were 24 mal...

journal_title：Annals of the New York Academy of Sciences

authors： Sheslow D,Hassink S,Wallace W,DeLancey E

更新日期：1993-10-29 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:The presented paper describes a multi-disciplinary cooling selection approach applied to major gas turbine engine hot section components, including turbine nozzles, blades, discs, combustors and support structures, which maintain blade tip clearances. The paper demonstrates benefits of close interaction between partic...

journal_title：Annals of the New York Academy of Sciences

authors： Glezer B

更新日期：2001-05-01 00:00:00

abstract：:Acetaldehyde covalently binds to purified tubulin in vitro to form both stable and unstable adducts. The formation of stable adducts can be greatly facilitated by the inclusion of the relatively gentle and Schiff base specific reducing agent, sodium cyanoborohydride. Although the tubulin molecule has multiple lysine r...

journal_title：Annals of the New York Academy of Sciences

authors： Tuma DJ,Jennett RB,Sorrell MF

更新日期：1987-01-01 00:00:00

abstract：:Phyloproteomics indicate common viral origin from ancient cells before archaea, bacteria, and eukaryota split and subsequent size and complexity reductions occurred. Further independent evidence for the cellular origin of viruses is reviewed for the virus order Megavirales, focusing on the family Poxviridae. Megaviral...

journal_title：Annals of the New York Academy of Sciences

authors： Seligmann H

更新日期：2019-07-01 00:00:00

abstract：:This paper describes the flight experiment, supporting ground science, and the design rationale for a project on spaceflight holography investigation in a virtual apparatus (SHIVA). SHIVA is a fundamental study of particle dynamics in fluids in microgravity. Gravitation effects and steady Stokes drag often dominate th...

journal_title：Annals of the New York Academy of Sciences

authors： Trolinger JD,L'Esperance D,Rangel RH,Coimbra CF,Witherow WK

更新日期：2004-11-01 00:00:00

abstract：:Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infe...

journal_title：Annals of the New York Academy of Sciences

authors： Hwang K,Yatsenko AN,Jorgez CJ,Mukherjee S,Nalam RL,Matzuk MM,Lamb DJ

更新日期：2010-12-01 00:00:00

abstract：:Azathioprine may be tried for treatment of severe myasthenia gravis, in a dose of 2 mg/kg BW. With careful monitoring the side reactions may be controlled. The therapeutic response will occur after a time delay of 4-8 months. About one-third of patients with type II MG (severe, late onset, HLA B8-) will proceed to a c...

journal_title：Annals of the New York Academy of Sciences

authors： Matell G

更新日期：1987-01-01 00:00:00

abstract：:Exposure to excessive levels of manganese, an essential trace element, can evoke severe psychiatric and extrapyramidal motor dysfunction closely resembling Parkinson's disease. The clinical manifestations of manganese toxicity arise from focal injury to the basal ganglia. This region, characterized by intense consumpt...

journal_title：Annals of the New York Academy of Sciences

authors： HaMai D,Bondy SC

更新日期：2004-03-01 00:00:00

abstract：:Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical research. It encompasses new treatments, advanced equipment, medical procedures, preventive and diagnostic approaches creating a bridge between basic studies and clinica...

journal_title：Annals of the New York Academy of Sciences

authors： Amirmahani F,Ebrahimi N,Molaei F,Faghihkhorasani F,Jamshidi Goharrizi K,Mirtaghi SM,Borjian-Boroujeni M,Hamblin MR

更新日期：2021-01-06 00:00:00

abstract：:Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

journal_title：Annals of the New York Academy of Sciences

authors： Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

更新日期：2019-01-01 00:00:00

abstract：:Aromatase cytochrome P450, the key enzyme of estrogen biosynthesis from androgens, is encoded by CYP19. Its structure shows some peculiarities: exons II to X encode the protein, while multiple alternative exons I encode unique 5'-untranslated regions of the aromatase mRNA transcripts. Immunohistochemistry studies in t...

journal_title：Annals of the New York Academy of Sciences

authors： Galmiche G,Corvaisier S,Kottler ML

更新日期：2006-07-01 00:00:00

abstract：:Bioelectrical impedance spectroscopy (BIS) can provide estimates of body composition for both whole body (WB) and body segments (BS). In normal, healthy subjects, BS measurements may be expected to serve as surrogates for WB indices; however, very little is known about this correspondence in people suffering from acut...

journal_title：Annals of the New York Academy of Sciences

authors： Mazariegos M,Klassen P,Solomons NW,Fürst P

更新日期：2000-05-01 00:00:00

abstract：:It is hypothesized that a phonemic processing deficit is a primary causal factor in the reading problems of many children with developmental dyslexia. An instructional model which emphasizes phonics instruction as a key in the treatment of children with reading disorders is presented. Procedures for the application of...

journal_title：Annals of the New York Academy of Sciences

authors： Richardson E

更新日期：1984-01-01 00:00:00

abstract：:N-type calcium channels both generate the initial calcium signal to trigger neurotransmitter release and also interact with synaptic release proteins at many mammalian central nervous system synapses. Two isoforms of the alpha 1B N-type channel from rat brain (alpha 1B-I and alpha 1B-II) were found to differ in four r...

journal_title：Annals of the New York Academy of Sciences

authors： Stea A,Dubel SJ,Snutch TP

更新日期：1999-04-30 00:00:00

abstract：:We have studied the conductance of molecular films as a function of orientation of the molecules in the film with respect to electrodes. Depending on the angle between the axis of the molecules and the normal to the electrode, the conductance may change by more than an order of magnitude. This is a consequence of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kornilovitch PE,Bratkovsky AM

更新日期：2002-04-01 00:00:00

abstract：:Natural systems cannot be closed to the environment. At the same time there is a necessity for closure in order to build the system. It is this quint-essential tension between openness and closure that drives systems to unfold into further stages or levels of growth and development. In other words, the emergence of or...

journal_title：Annals of the New York Academy of Sciences

authors： Alvarez De Lorenzana JM

更新日期：2000-01-01 00:00:00

abstract：:Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut perme...

journal_title：Annals of the New York Academy of Sciences

authors： Sung MK,Yeon JY,Park SY,Park JH,Choi MS

更新日期：2011-07-01 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00