Polycystic ovary syndrome in adolescence.

Abstract:

:The definition of polycystic ovary syndrome in very young girls is complicated by the fact that many features typical of the syndrome can also be seen as physiological stages in the maturation of the hypothalamus-pituitary-ovarian axis. The role of reduced insulin sensitivity in the pathogenesis and evolution of the disorder has gained more importance over recent years: both elevated androgen levels and being overweight may influence the impairment of glucose metabolism. Our study focused on 250 girls in the first 8 years of gynecological age. We analyzed the prevalence of different phenotypes according to the Rotterdam criteria and the impact of higher BMI on androgen levels and on fasting screening markers of glucose metabolism. In a smaller sample, we performed a more detailed evaluation of the glucose metabolism parameters; our findings indicated that in this age group, being overweight plays a major role in the deterioration of the clinical picture.

journal_name

Ann N Y Acad Sci

authors

Bruni V,Dei M,Nannini S,Balzi D,Nuvolone D

doi

10.1111/j.1749-6632.2010.05648.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

175-84

eissn

0077-8923

issn

1749-6632

journal_volume

1205

pub_type

杂志文章,评审
  • The specificity and sensitivity of uninhibited COR in labyrinthine-defective patients.

    abstract::The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generatin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.055

    authors: Carmona S,Nieto D

    更新日期:2005-04-01 00:00:00

  • Production of neurotoxic factors by brain endothelium in Alzheimer's disease.

    abstract::The cerebral vasculature is central to the maintenance of the neuronal microenvironment. We have previously demonstrated that brain microvessels in Alzheimer's disease produce high, potentially toxic, levels of nitric oxide. It is our hypothesis that neuronal injury in Alzheimer's disease occurs because an abnormal en...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb48460.x

    authors: Grammas P,Botchlet TR,Moore P,Weigel PH

    更新日期:1997-09-26 00:00:00

  • Pathological findings of HIV-associated cardiovascular disease.

    abstract::More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03901.x

    authors: d'Amati G,di Gioia CR,Gallo P

    更新日期:2001-11-01 00:00:00

  • Environmental protection, inequality, and institutional change.

    abstract::The contemporary world faces an unprecedented environmental challenge. Past international research has amply shown that we cannot afford to wait for a "development path" that automatically takes us on a sustainable future. Whether we look at global or local problems, the international debate increasingly points to the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05939.x

    authors: Magnani E

    更新日期:2011-02-01 00:00:00

  • Influence of interleukin-1 receptor antagonist on [3H]serotonin and histamine release by rat basophilic leukemia-2H3 cells.

    abstract::Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb46250.x

    authors: Conti P,Barbacane RC,Trakatellis M,Placido FC,Cataldo I,Reale M

    更新日期:1997-12-15 00:00:00

  • Resource depletion, pollen coupling, and the ecology of mast seeding.

    abstract::Masting, the highly variable and synchronous production of seeds across a population of perennial plants, is an ecologically important, but still poorly understood, phenomenon. While much is known about the fitness benefits of masting and its effects on seed consumers and trophic interactions, less is understood about...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12465

    authors: Crone EE,Rapp JM

    更新日期:2014-08-01 00:00:00

  • Intratympanic therapy for Ménière's disease. High-concentration gentamicin with round-window protection.

    abstract::Many therapeutic options exist for the management of patients with Ménière's disease. In the last few years, the use of intratympanic gentamicin has been investigated as an alternative treatment to vestibular nerve section or labyrinthectomy. In humans, the concentration of gentamicin used for intratympanic treatment ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08658.x

    authors: Quaranta A,Aloisi A,De Benedittis G,Scaringi A

    更新日期:1999-11-28 00:00:00

  • Fetal origins of adult diabetes.

    abstract::According to the fetal origin of adult diseases hypothesis, the intrauterine environment through developmental plasticity may permanently influence long-term health and disease. Therefore, intrauterine growth restriction (IUGR), due either to maternal, placental, or genetic factors, may permanently alter the endocrine...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05683.x

    authors: Kanaka-Gantenbein C

    更新日期:2010-09-01 00:00:00

  • Natural mentoring relationships among survivors of caregiver childhood abuse: findings from the Add Health Study.

    abstract::Social support promotes resilience to adverse childhood events, but little is known about the role of natural mentors-caring, nonparental adults-in the lives of childhood abuse survivors. The current study draws from a large, longitudinal, nationally representative sample (Add Health) to examine the prevalence and cha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14313

    authors: Weber Ku EB,Hagler MA,Parnes MF,Schwartz SEO,Rhodes JE,Erickson LD

    更新日期:2021-01-01 00:00:00

  • Tocotrienol: the natural vitamin E to defend the nervous system?

    abstract::Vitamin E is essential for normal neurological function. It is the major lipid-soluble, chain-breaking antioxidant in the body, protecting the integrity of membranes by inhibiting lipid peroxidation. Mostly on the basis of symptoms of primary vitamin E deficiency, it has been demonstrated that vitamin E has a central ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1331.013

    authors: Sen CK,Khanna S,Roy S

    更新日期:2004-12-01 00:00:00

  • Sequence patterns observed in 5' flanking regions of primate Alu elements.

    abstract::Retrotransposons have generally been known to integrate randomly into host genomes. Jurka, however, showed some consensus sequence patterns at insertion sites of some mammalian retrotransposons and proposed enzymatic involvement that mediates integration. Jurka used about 400 complete human Alu and rodent ID sequences...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08905.x

    authors: Toda Y,Saito R,Tomita M

    更新日期:1999-05-18 00:00:00

  • Electrical injuries in Canadian burn care. Identification of unsolved problems.

    abstract::Over the past decade, the Firefighters' Burn Treatment Unit of the University of Alberta Hospital in Edmonton, Alberta, Canada, has treated 1399 inpatients suffering from thermal injury. Regional burn care is provided in a 10-bed intensive care unit with 18 plastic surgery reconstructive beds for a large referral regi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07943.x

    authors: Tredget EE,Shankowsky HA,Tilley WA

    更新日期:1999-10-30 00:00:00

  • Characteristics of analgesias induced by brief or prolonged stress.

    abstract::Some characteristics of the effects of brief and prolonged stress on tail-flick latency are described. The pharmacological profiles of the latency responses to 30 sec and 30 min footshock are strikingly different. Thus, the increase of tail-flick latency after 30 sec shock is unaffected by naloxone and enhanced by dru...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1986.tb14621.x

    authors: Curzon G,Hutson PH,Kennett GA,Marcou M,Gower A,Tricklebank MD

    更新日期:1986-01-01 00:00:00

  • Characterization of the PAC1 variants expressed in the mouse heart.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide, exerts a variety of physiological functions through three types of G protein-coupled receptors, PAC1, VPAC1, and VAPC2. Characterization of the molecular forms of PAC1 in mouse heart revealed the presence of four types of variant r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1317.086

    authors: Ushiyama M,Sugawara H,Inoue K,Kangawa K,Yamada K,Miyata A

    更新日期:2006-07-01 00:00:00

  • A regional approach to assess the impact of living in a chemical world.

    abstract::In the United States, some 80,000 commercial and industrial chemicals are now in use of which over 30,000 are produced or used in the Great Lakes region. Thus, the environmental quality within the Great Lakes basin has been compromised particularly with respect to persistent toxic substances (PTS). Information derived...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1371.028

    authors: De Rosa CT,Hicks HE,Ashizawa AE,Pohl HR,Mumtaz MM

    更新日期:2006-09-01 00:00:00

  • The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence.

    abstract::Based on the relation found to exist between low CSF 5-HIAA and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-HT metabolism is related to (auto)aggression, rather than to depression. We chall...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb27895.x

    authors: Van Praag HM,Plutchik R,Conte H

    更新日期:1986-01-01 00:00:00

  • Motivational influences on the degree and direction of sexual attraction.

    abstract::Motivation can be defined as a class of central nervous processes determining the likelihood of display of a behavior and the intensity of the behavior if displayed. All behavior is, according to this definition, caused and controlled by motivation. Although the concept of motivation eventually could be replaced by an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1417.010

    authors: Hernández-González M,Guevara MA,Agmo A

    更新日期:2008-01-01 00:00:00

  • Interaction of bradykinin with angiotensin, prostacyclin, and nitric oxide in myocardial preservation.

    abstract::This review focuses on the importance of bradykinin in myocardial preservation during ischemic arrest. Bradykinin is released from the heart spontaneously in response to ischemic stress, which may be viewed as a survival signal of the heart against ischemia. Bradykinin appears to function as a signaling molecule by co...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb09244.x

    authors: Sato M,Das DK,Engelman RM

    更新日期:1999-06-30 00:00:00

  • Effects of phytochemicals on thyroid function and their possible role in thyroid disease.

    abstract::About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13980

    authors: Pistollato F,Masias M,Agudo P,Giampieri F,Battino M

    更新日期:2019-05-01 00:00:00

  • A dual spinal cord lesion paradigm to study spinal locomotor plasticity in the cat.

    abstract::After a complete spinal cord injury (SCI) at the lowest thoracic level (T13), adult cats trained to walk on a treadmill can recover hindlimb locomotion within 2-3 weeks, resulting from the activity of a spinal circuitry termed the central pattern generator (CPG). The role of this spinal circuitry in the recovery of lo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2012.06823.x

    authors: Martinez M,Rossignol S

    更新日期:2013-03-01 00:00:00

  • Linguistic uncertainty in qualitative risk analysis and how to minimize it.

    abstract::Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1399.003

    authors: Carey JM,Burgman MA

    更新日期:2008-04-01 00:00:00

  • Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer.

    abstract::Growing evidence indicates that deregulation of the epigenetic machinery comprising the microRNA (miRNA) network is a critical factor in the progression of various diseases, including cancer. Concurrently, dietary phytochemicals are being intensively studied for their miRNA-mediated health-beneficial properties, such ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13372

    authors: Kumar A,Rimando AM,Levenson AS

    更新日期:2017-09-01 00:00:00

  • The neural mechanisms of visual selection: the view from neuropsychology.

    abstract::In this review, we discuss how neuropsychological impairments in visual selection can inform us about how selection normally operates. Using neuroanatomical and behavioral evidence on the disorders of neglect, extinction, and simultanagnosia, we propose functional and anatomical links between different aspects of visu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05448.x

    authors: Riddoch MJ,Chechlacz M,Mevorach C,Mavritsaki E,Allen H,Humphreys GW

    更新日期:2010-03-01 00:00:00

  • Molecular immunogenetics in susceptibility to bovine dermatophilosis: a candidate gene approach and a concrete field application.

    abstract::To identify molecular genetic markers of resistance or susceptibility to dermatophilosis in cattle, we used a functional candidate gene approach to analyze the DNA polymorphisms of targeted genes encoding molecules implicated in known mechanisms of both nonspecific and specific immune responses existing in the pathoge...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04357.x

    authors: Maillard JC,Chantal I,Berthier D,Thevenon S,Sidibe I,Razafindraibe H

    更新日期:2002-10-01 00:00:00

  • Ixodes ovatus Ehrlichia exhibits unique ultrastructural characteristics in mammalian endothelial and tick-derived cells.

    abstract::Tick-borne pathogens in the genus Ehrlichia cause emerging zoonoses. Although laboratory mice are susceptible to Ehrlichia infections, many isolates do not cause clinical illness. In contrast, the Ixodes ovatus Ehrlichia-like agent (IOE) causes disease and immune responses in mice comparable to the human illness cause...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04520.x

    authors: Munderloh UG,Silverman DJ,MacNamara KC,Ahlstrand GG,Chatterjee M,Winslow GM

    更新日期:2009-05-01 00:00:00

  • Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy.

    abstract::Despite the documented association between apolipoprotein E genotype and cerebral amyloid angiopathy (CAA), a substantial proportion of CAA-related hemorrhages occur in patients without known risks for this disorder. Two other factors implicated in the pathogenesis of CAA are the amyloid-beta peptide (preferentially d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06361.x

    authors: Greenberg SM,Cho HS,O'Donnell HC,Rosand J,Segal AZ,Younkin LH,Younkin SG,Rebeck GW

    更新日期:2000-04-01 00:00:00

  • SNAP-25 in neuropsychiatric disorders.

    abstract::SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03995.x

    authors: Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

    更新日期:2009-01-01 00:00:00

  • Increased apoptotic cell death in sporadic and genetic Alzheimer's disease.

    abstract::Mounting evidence indicates increased susceptibility to cell death and increased oxidative damage as common features in neurons from sporadic Alzheimer's disease (AD) patients but also from familial AD (FAD) cases. Autosomal dominant forms of FAD are caused by mutations of the amyloid precursor protein (APP) gene and ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1299.113

    authors: Eckert A,Marques CA,Keil U,Schüssel K,Müller WE

    更新日期:2003-12-01 00:00:00

  • A toolbox of recombinant lipases for industrial applications.

    abstract::We created a toolbox of recombinant, microbial lipases, which allows us in combination with a lipase database to choose among the overexpressed lipases the most appropriate for a specific application and to improve it further via mutagenesis. By systematic comparison of geometry and properties of the scissile fatty ac...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10284.x

    authors: Schmidt-Dannert C,Pleiss J,Schmid RD

    更新日期:1998-12-13 00:00:00

  • The porous boundaries between explicit and implicit memory: behavioral and neural evidence.

    abstract::Explicit memory refers to the conscious retrieval of past information or experiences, whereas implicit memory refers to an unintentional or nonconscious form of retrieval. Much of the literature in cognitive psychology and cognitive neuroscience has focused on differences between explicit and implicit memory, and the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05946.x

    authors: Dew ITZ,Cabeza R

    更新日期:2011-04-01 00:00:00