Finnish model of peer-group mentoring: review of research.

abstract：:To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were amino...

journal_title：Annals of the New York Academy of Sciences

authors： Huang MJ,Regunathan S,Botta M,Lee K,McClendon E,Yi GB,Pedersen ML,Berkowitz DB,Wang G,Travagli M,Piletz JE

更新日期：2003-12-01 00:00:00

abstract：:Little is known about the role of the basolateral amygdala (BLA) in regulating hypothalamic-pituitary-adrenal (HPA) activity, particularly chronic stress-induced HPA activity. In the current studies, we examined the effects of manipulations of the BLA on HPA responses to the eighth restraint, to novel restraint after ...

journal_title：Annals of the New York Academy of Sciences

authors： Bhatnagar S,Vining C,Denski K

更新日期：2004-12-01 00:00:00

abstract：:"Module networks" are a framework to learn gene regulatory networks from expression data using a probabilistic model in which coregulated genes share the same parameters and conditional distributions. We present a method to infer ensembles of such networks and an averaging procedure to extract the statistically most s...

journal_title：Annals of the New York Academy of Sciences

authors： Michoel T,De Smet R,Joshi A,Marchal K,Van de Peer Y

更新日期：2009-03-01 00:00:00

abstract：:Carboxyfullerenes, including two regioisomers C3 and D3, were investigated as antioxidants against iron-induced oxidative stress in vivo and in vitro. Both C3 and D3 dose-dependently inhibited autoxidation and iron-elevated lipid peroxidation in cortical homogenates. The antioxidative property of C3 was compared to Tr...

journal_title：Annals of the New York Academy of Sciences

authors： Lin AM,Luh TY,Chou CK,Ho LT

更新日期：1999-01-01 00:00:00

abstract：:Kinetics of extracellular RNA accumulation in culture medium and at the cell surface along with their composition and distribution among cell-free and cell-surface-bound fractions were investigated in mycoplasma-contaminated and mycoplasma-free HeLa cells. It was shown that the mycoplasma infection influenced the conc...

journal_title：Annals of the New York Academy of Sciences

authors： Morozkin ES,Rykova EY,Vlassov VV,Laktionov PP

更新日期：2006-09-01 00:00:00

abstract：:Although tissue injury can evoke significant hyperalgesia in infants from the first days of life, little is known about how injury affects emergent central pain networks at the synaptic level. Recent studies have investigated whether tissue damage at different ages has distinct consequences for synaptic function in th...

journal_title：Annals of the New York Academy of Sciences

authors： Baccei ML

更新日期：2010-06-01 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:Ischemia and reperfusion injure the heart, as manifested by myocardial infarction, postischemic ventricular functional dysfunctions, arrhythmias, and cardiomyocyte apoptosis. Hearts can be adapted to ischemic-reperfusion injury by subjecting them to non-lethal cyclic episodes of short-term ischemia and reperfusion. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Maulik N,Sasaki H,Galang N

更新日期：1999-06-30 00:00:00

abstract：:The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long-standing standards of care that include low-molecular-weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, trial designs, and sta...

journal_title：Annals of the New York Academy of Sciences

authors： Hanna MS,Mohan P,Knabb R,Gupta E,Frost C,Lawrence JH

更新日期：2014-11-01 00:00:00

abstract：:RAS interacts with multiple targets in the cell and controls at least two signaling pathways, one regulating extracellular signal-regulated kinase (ERK) activation and the other controlling membrane ruffling formation. These two pathways appear to act synergistically to cause transformation. Human smooth muscle alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar CC,Ohashi K,Nagata K,Walsh A,Bar-Sagi D,Mizuno K

更新日期：1999-01-01 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Bisphosphonates are widely used in the management of metastatic disease to bone and in diseases of altered bone turnover. Recently, multiple-case series and retrospective studies have established a relationship between necrotic bone lesions localized to the jaw and the use of chronic bisphosphonate therapy. This condi...

journal_title：Annals of the New York Academy of Sciences

authors： Ruggiero SL

更新日期：2011-02-01 00:00:00

abstract：:Genomic sequence data provide evidence for a common origin of life and for its evolution by genetic variation via mutation and recombination. This paper discusses the fundamental dialectic paradigm of evolution--stability versus variability--at the crossroads of molecular genetics, population genetics, ecology, and th...

journal_title：Annals of the New York Academy of Sciences

authors： Radman M,Matic I,Taddei F

更新日期：1999-05-18 00:00:00

abstract：:We have previously described proopiomelanocortin (POMC) gene-expression in human normal cultured dermal fibroblasts, and its dose- and time-dependent modulation by transforming growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha). The aim of the work described here was to investigate POMC-derived ...

journal_title：Annals of the New York Academy of Sciences

authors： Teofoli P,Frezzolini A,Puddu P,De Pità O,Mauviel A,Lotti T

更新日期：1999-10-20 00:00:00

abstract：:Osmotic opening of the blood-brain barrier (BBB) most likely is mediated by modification of interendothelial tight junctions, subsequent to shrinkage of cerebrovascular endothelial cells, and not by stimulation of transendothelial vesicular transport or by channel formation. This paper summarizes evidence for this con...

journal_title：Annals of the New York Academy of Sciences

authors： Rapoport SI,Robinson PJ

更新日期：1986-01-01 00:00:00

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:Hamster sperm DNA is packaged so tightly that it is the most highly condensed eukaryotic DNA known. Nevertheless, the sperm genome is also organized in a very specific fashion by two nuclear structures, the nuclear matrix and the nuclear annulus. The nuclear matrix organizes sperm DNA into loop domains approximately 4...

journal_title：Annals of the New York Academy of Sciences

authors： Farrington JE,Patel R,Ward WS

更新日期：1991-01-01 00:00:00

abstract：:The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally ...

journal_title：Annals of the New York Academy of Sciences

authors： Gibson MK,Dhaliwal AS,Clemons NJ,Phillips WA,Dvorak K,Tong D,Law S,Pirchi ED,Räsänen J,Krasna MJ,Parikh K,Krishnadath KK,Chen Y,Griffiths L,Colleypriest BJ,Farrant JM,Tosh D,Das KM,Bajpai M

更新日期：2013-10-01 00:00:00

abstract：:The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the striking ability of 17-beta estradiol (E2) and its derivatives to inhibit clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in mi...

journal_title：Annals of the New York Academy of Sciences

authors： Offner H,Polanczyk M

更新日期：2006-11-01 00:00:00

abstract：:Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon-rich genomes common among plants). In ciliates, a group of microbial eukaryotes with distinct somatic an...

journal_title：Annals of the New York Academy of Sciences

authors： Maurer-Alcalá XX,Nowacki M

更新日期：2019-07-01 00:00:00

abstract：:Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member...

journal_title：Annals of the New York Academy of Sciences

authors： Allez M,Brimnes J,Shao L,Dotan I,Nakazawa A,Mayer L

更新日期：2004-12-01 00:00:00

abstract：:The epsilon 4 allele of apolipoprotein E (APOE) is strongly associated with late-onset Alzheimer's disease (AD) in Caucasian populations, but our studies suggest that APOE epsilon 4 is not a risk factor for AD in Nigerian blacks and is a weak risk factor in African-Americans. The prevalence of AD is lower in Nigerians...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Xu Y,Klaunig J,Baiyewu O,Ogunniyi A,Hall K,Hendrie H,Sahota A

更新日期：1999-01-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:Aging may pose a challenge to the central nervous system, increasing its susceptibility to apoptotic events. Recent findings indicate that caloric restriction (CR) may have a profound effect on brain function and vulnerability to injury and diseases, by enhancing neuroprotection, stimulating the production of new neur...

journal_title：Annals of the New York Academy of Sciences

authors： Hiona A,Leeuwenburgh C

更新日期：2004-06-01 00:00:00

abstract：:Modest changes in gene expression of three-fold or less might be expected after mild to moderate neurotoxic exposure to classes of compounds, such as the substituted amphetamines, or at time points that are weeks after more severe neurotoxic exposures. When many genes appear to change expression by less than two-fold,...

journal_title：Annals of the New York Academy of Sciences

authors： Delongchamp RR,Harris AJ,Bowyer JF

更新日期：2003-05-01 00:00:00

abstract：:It is known that Delta(9)-tetrahydrocannabinol (THC), the major active ingredient of marijuana, can suppress reproductive function. Also, we reported previously that the endocannabinoid, anandamide (AEA), inhibited gonadotropin-releasing hormone (LHRH) release from medial basal hypothalamus (MBH) of male rats incubate...

journal_title：Annals of the New York Academy of Sciences

authors： Fernandez-Solari J,Prestifilippo JP,Bornstein SR,McCann SM,Rettori V

更新日期：2006-11-01 00:00:00

abstract：:Access to experimental X-ray diffraction image data is important for validation and reproduction of macromolecular models and indispensable for the development of structural biology processing methods. In response to the evolving needs of the structural biology community, we recently established a diffraction data pub...

journal_title：Annals of the New York Academy of Sciences

authors： McKinney B,Meyer PA,Crosas M,Sliz P

更新日期：2017-01-01 00:00:00

abstract：:Hematopoietic development in the mammal can be represented as a numerically expanding hierarchy of cell populations that are progressively restricted in their self-renewal and differentiation abilities. Classical functional studies have now been extended to provide exact physical descriptions of various stages in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Lemischka I

更新日期：1999-04-30 00:00:00