Evolutionary origins and impacts of genome architecture in ciliates.

abstract：:Although pancreatic adenocarcinoma has become one of the best characterized malignant diseases, severe diagnostic and therapeutic problems are still associated with this disease. The establishment of a molecular model of pancreatic carcinogenesis may provide tools that could result in earlier diagnosis of this disease...

journal_title：Annals of the New York Academy of Sciences

authors： Jesnowski R,Müller P,Schareck W,Liebe S,Löhr M

更新日期：1999-06-30 00:00:00

abstract：:This chapter discusses the influence of drama in the author's background in conceptualizing psychoanalytic theory and practice. The history of ideas relevant to a dramaturgical analysis from Freud to Kohut's revolution, with additional modifications by relational psychoanalysis, is explored. The author poses a trimoda...

journal_title：Annals of the New York Academy of Sciences

authors： Ringstrom PA

更新日期：2009-04-01 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) has been implicated in the modulation of aggression in animals and humans. A longstanding dogma that aggression and serotonergic activity are inversely related has to be abandoned in light of many new findings. Trait and state aggression are differentially regulated by the 5-HT sy...

journal_title：Annals of the New York Academy of Sciences

authors： Olivier B

更新日期：2004-12-01 00:00:00

abstract：:The existence of a covalent intermediate in topoisomerase I catalysis allows uncoupling of the cleavage and ligation half-reactions on partially single-stranded DNA substrates containing a highly preferred interaction site. Using this model DNA substrate system we have demonstrated that the cleavage reaction requires ...

journal_title：Annals of the New York Academy of Sciences

authors： Christiansen K,Westergaard O

更新日期：1996-12-13 00:00:00

abstract：:This paper is intended to serve as a traditional Tibetan medical response to advancements in basic longevity research, with particular attention to current models of caloric restriction. This is a complicated task, as Tibetan medicine traditionally approaches dietary modification from a radically different perspective...

journal_title：Annals of the New York Academy of Sciences

authors： Dakpa T,Dodson-Lavelle B

更新日期：2009-08-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:A cholinergic hypofunction in Alzheimer's disease (AD) may lead to formation of beta-amyloids that might impair the coupling of M1 muscarinic ACh receptors (mAChRs) with G proteins. This disruption in coupling can lead to decreased signal transduction, to a reduction in levels of trophic amyloid precursor proteins (AP...

journal_title：Annals of the New York Academy of Sciences

authors： Fisher A,Michaelson DM,Brandeis R,Haring R,Chapman S,Pittel Z

更新日期：2000-01-01 00:00:00

abstract：:Although tissue injury can evoke significant hyperalgesia in infants from the first days of life, little is known about how injury affects emergent central pain networks at the synaptic level. Recent studies have investigated whether tissue damage at different ages has distinct consequences for synaptic function in th...

journal_title：Annals of the New York Academy of Sciences

authors： Baccei ML

更新日期：2010-06-01 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:Methamphetamine (METH) produces nigrostriatal dopamine (DA) loss, partly resembling that which occurs in Parkinson's disease (PD). In PD there is also a marked alteration in the gut. Given the similarities between the central DA denervation produced by METH and PD, in the present study we evaluated the alterations in ...

journal_title：Annals of the New York Academy of Sciences

authors： Natale G,Kastsiuchenka O,Pasquali L,Ruggieri S,Paparelli A,Fornai F

更新日期：2008-10-01 00:00:00

abstract：:Aging may pose a challenge to the central nervous system, increasing its susceptibility to apoptotic events. Recent findings indicate that caloric restriction (CR) may have a profound effect on brain function and vulnerability to injury and diseases, by enhancing neuroprotection, stimulating the production of new neur...

journal_title：Annals of the New York Academy of Sciences

authors： Hiona A,Leeuwenburgh C

更新日期：2004-06-01 00:00:00

abstract：:The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...

journal_title：Annals of the New York Academy of Sciences

authors： Santibáñez S,Ibarra V,Portillo A,Blanco JR,Martínez de Artola V,Guerrero A,Oteo JA

更新日期：2006-10-01 00:00:00

abstract：:Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothel...

journal_title：Annals of the New York Academy of Sciences

authors： Shelton EL,Bader DM

更新日期：2012-10-01 00:00:00

abstract：:Like many other transcription factors, the tumor suppressor protein p53 is bound to the nuclear matrix (NM). To study the interaction of p53 with the NM in more detail, we used alkaline and acidic extractions of NM proteins. It was found that there are two forms of p53, alkali- and acid-soluble, in NM of HEK293 cells ...

journal_title：Annals of the New York Academy of Sciences

authors： Lapshina MA,Parkhomenko II,Terentiev AA

更新日期：2006-12-01 00:00:00

abstract：:This study measured on-road driving behavior in subjects with bilateral vestibular loss (BVL). Data included point-of-regard (what the driver is looking at and attending to), gaze stability (the performance of the vestibulo-ocular reflex), and head movement, during complex maneuvers such as changing lanes, cornering, ...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Moore ST,Black RA,Jolly N,Curthoys IS

更新日期：2009-05-01 00:00:00

abstract：:The essential trace element selenium is of fundamental importance to human biology. Information on the membrane-bound selenoproteins was obtained by labeling of rats in vivo with (75)Se-selenite, subcellular fractionation of the tissue homogenates, separation of the proteins by SDS-PAGE, two-dimensional electrophoresi...

journal_title：Annals of the New York Academy of Sciences

authors： Kyriakopoulos A,Bertelsmann H,Graebert A,Hoppe B,Kuhbacher M,Behne D

更新日期：2002-11-01 00:00:00

abstract：:These data suggest that shock stress during adolescence increases ETOH consumption and may contribute to an increase in aggression in early adulthood. Interestingly, shock stress without ETOH results in timid behavior in early adulthood. One might speculate that adolescent hamsters "self-medicate" to deal with continu...

journal_title：Annals of the New York Academy of Sciences

authors： Ferris CF,Brewer J

更新日期：1996-09-20 00:00:00

abstract：:Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a ...

journal_title：Annals of the New York Academy of Sciences

authors： Conti P,Barbacane RC,Trakatellis M,Placido FC,Cataldo I,Reale M

更新日期：1997-12-15 00:00:00

abstract：:Alzheimer's disease (AD) impairs olfaction, but it is uncertain how early this occurs in the disease process and whether the effect can be accounted for by other behavioral or genetic markers of the disease. We administered the Brief Smell Identification Test (BSIT) to 471 older people without dementia or cognitive im...

journal_title：Annals of the New York Academy of Sciences

authors： Wilson RS,Arnold SE,Schneider JA,Boyle PA,Buchman AS,Bennett DA

更新日期：2009-07-01 00:00:00

abstract：:The contact area of bubbles with a transparent heating surface was optically measured during subcooled pool boiling of water on the ground. In the experiments, boiling bubbles were attached to the heating surface with a bubble holder and nearly reproduced the bubble behavior observed in low gravity. DC power was appli...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Takahashi S,Ohta H

更新日期：2004-11-01 00:00:00

abstract：:Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic ph...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HJ,Lee KW,Lee HJ

更新日期：2007-01-01 00:00:00

abstract：:Hereditary adrenal pheochromocytoma is caused by germline mutations in RET, VHL, SDHB, SDHD, and NF1. As these genes differ in function, so may their pheochromocytoma phenotypes, suggesting gene-specific patterns of age-related progression to pheochromocytoma. This possibility was explored for gene carriers with a lif...

journal_title：Annals of the New York Academy of Sciences

authors： Machens A,Brauckhoff M,Gimm O,Dralle H

更新日期：2006-08-01 00:00:00

abstract：:We have defined three sets of HLA-DR3(+) haplotypes that provide maximum risk of type 1 disease development in Indians: (1) a diverse array of B8-DR3 haplotypes, (2) A33-B58-DR3 haplotype, and (3) A2-B50-DR3 occurring most predominantly in this population. Further analysis has revealed extensive diversity in B8-DR3 ha...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar N,Kaur G,Tandon N,Kanga U,Mehra NK

更新日期：2013-04-01 00:00:00

abstract：:Indirect and direct experimental evidence demonstrates that both the entry of extracellular calcium and the liberation of calcium from intracellular stores can contribute to an increase in free cytoplasmic calcium concentration in endothelial cells, which seems to be an essential step in the synthesis and/or release o...

journal_title：Annals of the New York Academy of Sciences

authors： Rubanyi GM,Vanhoutte PM

更新日期：1988-01-01 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:Many studies have now indicated that micronutrients, such as the carotenoids, tocopherols, and ascorbic acid, can prevent mutagenesis, genotoxic effects, or malignant transformation in bacteria and mammalian tissue, either in cell culture or in organ culture. In addition, multiple papers report that some of these micr...

journal_title：Annals of the New York Academy of Sciences

authors： Krinsky NI

更新日期：1993-05-28 00:00:00

abstract：:Human alpha 2-antiplasmin (alpha 2AP) is the primary inhibitor of plasmin-mediated fibrinolysis and is an efficient substrate of activated factor XIII (FXIIIa). Among 452 amino acid residues in alpha 2AP, Gln2 is believed to be the sole FXIIIa-reactive site that participates in crosslinking alpha 2AP to fibrin. We stu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee KN,Lee CS,Tae WC,Jackson KW,Christiansen VJ,McKee PA

更新日期：2001-01-01 00:00:00

abstract：:The concepts of the ventral striatopallidal system and extended amygdala have significantly improved our understanding of basal forebrain organization. As a result of these and other advances during the last twenty years, many of the most prominent basal forebrain structures, including the nucleus accumbens, olfactory...

journal_title：Annals of the New York Academy of Sciences

authors： de Olmos JS,Heimer L

更新日期：1999-06-29 00:00:00

abstract：:Advanced glycation end products (AGEs) are the result of a nonenzymatic reaction of reducing sugars with primary amino groups of proteins (Maillard reaction). They accumulate in various tissues in the course of aging. Because AGEs induce protein cross-links and oxidative stress (radicals) within cells and tissues, the...

journal_title：Annals of the New York Academy of Sciences

authors： Simm A,Bartling B,Silber RE

更新日期：2004-06-01 00:00:00

abstract：:Taxonomic characterization of organisms in the genera Theileria and Babesia was originally based on observations of morphology and certain general phenotypic characteristics, which enabled many parasites to be unequivocally assigned to a particular genus. However, application of molecular genetic techniques, such as t...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp MT,Allsopp BA

更新日期：2006-10-01 00:00:00