The effect of camptothecin on topoisomerase I catalysis.

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:The purpose of the present experiment was to determine if there is a factor in serum of patients with myasthenia gravis (MG) that interferes with binding of (125I)-alpha-bungarotoxin to acetylcholine receptors of normal mouse diaphragm. Diaphragms were incubated aerobically for 1 hour in either Krebs-Henseleit solutio...

journal_title：Annals of the New York Academy of Sciences

authors： Keesey J,Shaikh I,Wolfgram F,Chao LP

更新日期：1976-01-01 00:00:00

abstract：:Decreased postural stability is observed in most astronauts immediately following spaceflight. Because ataxia may present postflight operational hazards, it is important to determine the incidence of postural instability immediately following landing and the dynamics of recovery of normal postural equilibrium control....

journal_title：Annals of the New York Academy of Sciences

authors： Paloski WH,Reschke MF,Black FO,Doxey DD,Harm DL

更新日期：1992-05-22 00:00:00

abstract：:The following on proton pump inhibitors (PPIs) and chemoprevention in relation to Barrett's esophagus includes commentaries on 48-h pH monitoring, pH-impedence, bile acid testing, dyspepsia, long/short segment Barrett's esophagus, nonerosive reflux disease (NERD), functional heartburn, dual-release delivery PPIs, imme...

journal_title：Annals of the New York Academy of Sciences

authors： Richter JE,Penagini R,Tenca A,Pohl D,Dvorak K,Goldman A,Savarino E,Zentilin P,Savarino V,Watson JT,Wong RK,Pace F,Casini V,Peura DA,Herzig SJ,Kamiya T,Pelosini I,Scarpignato C,Armstrong D,DeVault KR,Bechi P,Tadd

更新日期：2011-09-01 00:00:00

abstract：:CYP21A2 genotyping remains an important element in the diagnosis and management of congenital adrenal hyperplasia, and establishing accurate genotype-phenotype correlations has facillitated adequate genetic counseling and prenatal management for at-risk families. Despite extensive efforts to establish a clear genotype...

journal_title：Annals of the New York Academy of Sciences

authors： Elmougy F,Sharaf S,Hafez M,Khattab A,Abou-Yousef H,Elsharkawy M,Baz H,Ekladious S,Sherif B,Musa N,Elshiwy Y,Afif A,Abdullatif M,Thabet G,Rady N,Ibrahim A,Soliman H

更新日期：2018-03-01 00:00:00

abstract：:The muscular dystrophies, which cause progressive weakening of the skeletal muscles, are frequently associated with cardiomyopathy. In fact, the leading cause of mortality in patients with Duchenne muscular dystrophy, the most common and most severe type of muscular dystrophy, is heart failure due to cardiomyopathy. T...

journal_title：Annals of the New York Academy of Sciences

authors： Kuno A,Tanno M,Horio Y

更新日期：2015-08-01 00:00:00

abstract：:The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulat...

journal_title：Annals of the New York Academy of Sciences

authors： Moutsatsou P,Sekeris CE

更新日期：1997-06-17 00:00:00

abstract：:Biologics are playing an increasingly significant role in the practice of modern medicine and surgery in general and orthopedics in particular. Cell-based approaches are among the most important and widely used modalities in orthopedic biologics, with mesenchymal stem cells and other multi/pluripotent cells undergoing...

journal_title：Annals of the New York Academy of Sciences

authors： Lebaschi A,Nakagawa Y,Wada S,Cong GT,Rodeo SA

更新日期：2017-12-01 00:00:00

abstract：:The research presented at this conference, including a series of excellent posters from junior investigators, documents the pervasive importance of affiliation and other social behaviors. Affiliative behaviors interact with, but are distinct from reproductive and aggressive behaviors. Patterns of social behaviors tend...

journal_title：Annals of the New York Academy of Sciences

authors： Carter CS,Lederhendler I,Kirkpatrick B

更新日期：1997-01-15 00:00:00

abstract：:Animal studies have already shown the possibility to modulate insulin action by changing not only the amount of total fat, but also the type of fat. In these studies, saturated fat significantly increased insulin resistance, long- and short-chain omega(3) fatty acids significantly improved it, whereas the effects of m...

journal_title：Annals of the New York Academy of Sciences

authors： Rivellese AA,De Natale C,Lilli S

更新日期：2002-06-01 00:00:00

abstract：:Legally, women, Native Americans, and African-Americans were defined by the American Constitution as inferior. The pragmatists gradually showed that all selves are equal. These ideas helped the minorities to attain nearly full legal status. But economic status is going in the other direction, toward inequality. It thr...

journal_title：Annals of the New York Academy of Sciences

authors： Wiley N

更新日期：2011-10-01 00:00:00

abstract：:Of the dideoxynucleosides described to date, the purine analogues ddA and ddI have exhibited very favorable therapeutic ratios in vitro. ddI is presently undergoing extensive phase I-II clinical trials. Whereas the action of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) is usually to convert a gi...

journal_title：Annals of the New York Academy of Sciences

authors： Fridland A,Johnson MA,Cooney DA,Ahluwalia G,Marquez VE,Driscoll JS,Johns DG

更新日期：1990-01-01 00:00:00

abstract：:Peripheral sympathetic nerve terminals in many tissues, but not all, are endowed with beta-adrenoceptors. Activation of these result in an enhancement of noradrenaline release evoked by electrical nerve stimulation. These so-called presynaptic beta-adrenoceptors are possibly located on the outer surface of the varicos...

journal_title：Annals of the New York Academy of Sciences

authors： Nedergaard OA,Abrahamsen J

更新日期：1990-01-01 00:00:00

abstract：:Immune stimulation increases the activity of the HPA axis, a phenomenon directly or indirectly mediated through cytokines. We have used two models, the peripheral administration of endotoxin (LPS) or turpentine-induced tissue injury to show that corticotropin-releasing factor (CRF) and vasopressin (VP), hypothalamic p...

journal_title：Annals of the New York Academy of Sciences

authors： Turnbull AV,Lee S,Rivier C

更新日期：1998-05-01 00:00:00

abstract：:We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Levanat S,Musani V,Komar A,Oreskovic S

更新日期：2004-12-01 00:00:00

abstract：:The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A ...

journal_title：Annals of the New York Academy of Sciences

authors： Yoo SH,So SH,Huh YH,Park HY

更新日期：2002-10-01 00:00:00

abstract：:The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

journal_title：Annals of the New York Academy of Sciences

authors： Blostein R,Pu HX,Scanzano R,Zouzoulas A

更新日期：2003-04-01 00:00:00

abstract：:Auditory brainstem potentials were recorded from various scalp and nasopharyngeal sites referenced both to a noncephalic site and to certain scalp locations in normal humans. The distribution of amplitudes and latencies of the components were defined. There were significant amplitude, polarity, and latency asymmetries...

journal_title：Annals of the New York Academy of Sciences

authors： Starr A,Squires K

更新日期：1982-01-01 00:00:00

abstract：:Reducing emissions from deforestation and forest degradation (REDD+) provides financial compensation to land owners who avoid converting standing forests to other land uses. In this paper, we review the main opportunities and challenges for REDD+ implementation, including expectations for REDD+ to deliver on multiple ...

journal_title：Annals of the New York Academy of Sciences

authors： Venter O,Koh LP

更新日期：2012-02-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or...

journal_title：Annals of the New York Academy of Sciences

authors： Padgett LE,Broniowska KA,Hansen PA,Corbett JA,Tse HM

更新日期：2013-04-01 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:The search for tumor markers suitable for use in diagnosis and management of patients with lung cancer has met with limited success because each available marker lacks sufficient sensitivity and specificity. We have begun a collaborative study to evaluate multiple simultaneous serum markers to determine whether there ...

journal_title：Annals of the New York Academy of Sciences

authors： McIntire KR,Radovich BT,Gail MH,Go VL

更新日期：1983-01-01 00:00:00

abstract：:The smooth muscle myosin heavy chain (MHC) gene and its isoforms are excellent molecular markers that reflect smooth muscle phenotypes. The SMemb/Nonmuscle Myosin Heavy Chain B (NMHC-B) is a distinct MHC gene expressed predominantly in phenotypically modulated SMCs (synthetic-type SMC). To dissect the molecular mechan...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai R,Suzuki T,Aizawa K,Miyamoto S,Amaki T,Kawai-Kowase K,Sekiguchi KI,Kurabayashi M

更新日期：2001-12-01 00:00:00

abstract：:Hydrogen sulfide (H2 S) is a highly neurotoxic gas. Acute exposure can lead to neurological sequelae among survivors. A drug for treating neurological sequelae in survivors of acute H2 S intoxication is needed. Using a novel mouse model we evaluated the efficacy of cobinamide (Cob) for increasing survival of, and redu...

journal_title：Annals of the New York Academy of Sciences

authors： Anantharam P,Whitley EM,Mahama B,Kim DS,Sarkar S,Santana C,Chan A,Kanthasamy AG,Kanthasamy A,Boss GR,Rumbeiha WK

更新日期：2017-11-01 00:00:00

abstract：:The proximate hurdle for cell trafficking to any anatomic site is the initial attachment of circulating cells to target tissue endothelium with sufficient strength to overcome prevailing forces of blood flow. E-selectin, an endothelial molecule that is inducibly expressed at all sites of inflammation, is a potent effe...

journal_title：Annals of the New York Academy of Sciences

authors： Sackstein R

更新日期：2012-04-01 00:00:00

abstract：:The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF. Immunohistochemical study showed that KDR exp...

journal_title：Annals of the New York Academy of Sciences

authors： Murota SI,Onodera M,Morita I

更新日期：2000-05-01 00:00:00

abstract：:Lipogenesis occurs primarily in the liver, where dietary carbohydrates control the expression of key enzymes in glycolytic and lipogenic pathways. We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid syn...

journal_title：Annals of the New York Academy of Sciences

authors： Glimcher LH,Lee AH

更新日期：2009-09-01 00:00:00

abstract：:Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measur...

journal_title：Annals of the New York Academy of Sciences

authors： Karakochuk CD,Hess SY,Moorthy D,Namaste S,Parker ME,Rappaport AI,Wegmüller R,Dary O,HEmoglobin MEasurement (HEME) Working Group.

更新日期：2019-08-01 00:00:00

abstract：:GABA and glutamate play a major role in central integration of hypothalamo-pituitary-adrenocortical (HPA) stress responses. Recent work in our group has focused on mechanisms whereby GABAergic and glutamatergic circuits interact with parvocellular paraventricular nucleus (PVN) neurons controlling the HPA axis. GABAerg...

journal_title：Annals of the New York Academy of Sciences

authors： Herman JP,Mueller NK,Figueiredo H

更新日期：2004-06-01 00:00:00

abstract：:Rapid cooling of small samples is necessary both to cryofixation for electron microscopy and to vitrification for cryopreservation. Several effects on the cooling rates of small samples quenched into liquid nitrogen were studied, including the diameter of samples, the subcooling of liquid nitrogen, the quenching speed...

journal_title：Annals of the New York Academy of Sciences

authors： Cao Q,Hua TC

更新日期：1998-09-11 00:00:00