Tissue-specific endothelial cells: a promising approach for augmentation of soft tissue repair in orthopedics.

Abstract:

:Biologics are playing an increasingly significant role in the practice of modern medicine and surgery in general and orthopedics in particular. Cell-based approaches are among the most important and widely used modalities in orthopedic biologics, with mesenchymal stem cells and other multi/pluripotent cells undergoing evaluation in numerous preclinical and clinical studies. On the other hand, fully differentiated endothelial cells (ECs) have been found to perform critical roles in homeostasis of visceral tissues through production of an adaptive panel of so-called "angiocrine factors." This newly discovered function of ECs renders them excellent candidates for novel approaches in cell-based biologics. Here, we present a review of the role of ECs and angiocrine factors in some visceral tissues, followed by an overview of current cell-based approaches and a discussion of the potential applications of ECs in soft tissue repair.

journal_name

Ann N Y Acad Sci

authors

Lebaschi A,Nakagawa Y,Wada S,Cong GT,Rodeo SA

doi

10.1111/nyas.13575

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

44-56

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1410

pub_type

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