Abstract:
:We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HLA)-DRB1/DQB1 profile. The dendrogram obtained using the Cluster program grouped patients and controls into three clusters, one including individuals with no susceptibility alleles, another including individuals with at least three susceptibility alleles, and a third intermingling susceptibility/protective alleles. In addition to other variables, the results of the present article suggest that the major histocompatibility complex (MHC) class II profile may be of relevance for the study of a large-scale differentially expressed genes.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Rassi DM,Junta CM,Fachin AL,Sandrin-Garcia P,Mello SS,Fernandes AP,Deghaide NN,Foss-Freitas MC,Foss MC,Sakamoto-Hojo ET,Passos GA,Donadi EAdoi
10.1196/annals.1375.046subject
Has Abstractpub_date
2006-10-01 00:00:00pages
305-9eissn
0077-8923issn
1749-6632pii
1079/1/305journal_volume
1079pub_type
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