Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.

abstract：:Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications. Advanced age is also associated with increased adiposity, decreased le...

journal_title：Annals of the New York Academy of Sciences

authors： Lee EB

更新日期：2011-12-01 00:00:00

abstract：:A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

journal_title：Annals of the New York Academy of Sciences

authors： Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

更新日期：2008-10-01 00:00:00

abstract：:More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS. ...

journal_title：Annals of the New York Academy of Sciences

authors： d'Amati G,di Gioia CR,Gallo P

更新日期：2001-11-01 00:00:00

abstract：:Growth and pubertal disturbances are the commonest endocrinopathies in homozygous thalassemia, accounting for significant morbidity in 70-80% children and adolescents globally. This review focuses on the pathophysiology of the endocrinopathy from a historical perspective and altered natural history induced by better c...

journal_title：Annals of the New York Academy of Sciences

authors： Chatterjee R,Bajoria R

更新日期：2010-08-01 00:00:00

abstract：:The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulat...

journal_title：Annals of the New York Academy of Sciences

authors： Moutsatsou P,Sekeris CE

更新日期：1997-06-17 00:00:00

abstract：:A new potent inhibitor of adenosine deaminase (co-vidarabine) was used in combination studies with adenine arabinoside (vidarabine, Vira-ATM) to protect this purine nucleoside from enzymatic deamination to the more weakly active metabolite, hypoxanthine arabinoside. Comparing the combination to vidarabine alone, a sig...

journal_title：Annals of the New York Academy of Sciences

authors： Sloan BJ,Kielty JK,Miller FA

更新日期：1977-03-04 00:00:00

abstract：:The incidence of autoimmune diseases is higher in females than in males. In both sexes, adrenal hormones, that is, glucocorticoids, dehydroepiandrosterone (DHEA), and androgens, are inadequately low in patients when compared to healthy controls. Hormonally active androgens are anti-inflammatory, whereas estrogens are ...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt M,Naumann H,Weidler C,Schellenberg M,Anders S,Straub RH

更新日期：2006-06-01 00:00:00

abstract：:Classic studies of the cerebellum before the middle of the twentieth century established the structural entity of the cerebellum and characterized its function as enabling animals and humans to carry out smooth and accurate movements, even at a high speed and without visual feedback. In the 1960s, neuronal circuit str...

journal_title：Annals of the New York Academy of Sciences

authors： Ito M

更新日期：2002-12-01 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus, which emerged in 1998 from fruit bats in Malaysia and caused an outbreak of severe respiratory disease in pigs and fatal encephalitis in humans with high mortality rates. In contrast to most paramyxoviruses, NiV can infect a large variety of mammalian species. Du...

journal_title：Annals of the New York Academy of Sciences

authors： Diederich S,Maisner A

更新日期：2007-04-01 00:00:00

abstract：:A new model for spatial convective transport processes conjugated with the measured or calculated realistic quasi-steady microaccelerations is presented. Rotation around the mass center, including accelerated rotation, gravity gradient, and aerodynamical drag are taken into account. New results of the effect on mixing...

journal_title：Annals of the New York Academy of Sciences

authors： Polezhaev VI,Nikitin SA

更新日期：2009-04-01 00:00:00

abstract：:The first step in cancer initiation is the reaction of chemical carcinogens with DNA to form stable adducts, which remain in DNA unless removed by repair, and depurinating adducts, which detach from DNA following destabilization of the glycosyl bond. Depurinating DNA adducts of polycyclic aromatic hydrocarbons play a ...

journal_title：Annals of the New York Academy of Sciences

authors： Cavalieri EL,Rogan EG

更新日期：2004-12-01 00:00:00

abstract：:Entomopathogenic fungi are promising alternatives to chemical acaricides in controlling tick populations; however, biological formulations are required to improve conidial performance of these pathogens in the field. This study evaluated the effect of in vitro treatment of Rhipicephalus sanguineus with conidial formul...

journal_title：Annals of the New York Academy of Sciences

authors： Reis RC,Fernandes EK,Bittencourt VR

更新日期：2008-12-01 00:00:00

abstract：:Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of ca...

journal_title：Annals of the New York Academy of Sciences

authors： Ganesan K,Xu B

更新日期：2017-08-01 00:00:00

abstract：:A diverse array of organisms live longer under dietary restriction. Here, a hypothesis is proposed as a framework for interpreting this phenomenon. Dietary restriction is explained in terms of evolution and antagonistic pleiotropy. Focusing on the decline in reproductive capacity seen in dietary restriction, it is sub...

journal_title：Annals of the New York Academy of Sciences

authors： Koochmeshgi J

更新日期：2004-06-01 00:00:00

abstract：:Homozygous beta thalassemia affects thousands of people around the world. Current management of this condition includes regular transfusion of red cells, which leads to transfusional iron overload requiring chelation therapy: increasing hemoglobin levels while decreasing or eliminating iron overload is therefore a maj...

journal_title：Annals of the New York Academy of Sciences

authors： Dover GJ

更新日期：1998-06-30 00:00:00

abstract：:The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

journal_title：Annals of the New York Academy of Sciences

authors： Mundy NI,Kelly J,Theron E,Hawkins K

更新日期：2003-06-01 00:00:00

abstract：:The authors present a multifactorial model for the development of acquired immunodeficiency syndrome (AIDS) in homosexual men. It is posited that there is no specific AIDS agent; rather, AIDS is conceptualized as the result of an interaction of the known or likely effects of repeated exposures to specific environment...

journal_title：Annals of the New York Academy of Sciences

authors： Sonnabend JA,Witkin SS,Purtilo DT

更新日期：1984-01-01 00:00:00

abstract：:Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul S,Padgett RC,Heistad DD

更新日期：1994-04-18 00:00:00

abstract：:The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

journal_title：Annals of the New York Academy of Sciences

authors： Ghosn EE,Yang Y

更新日期：2015-12-01 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:Local activation of macrophages may play an important role in the immune process of pulmonary infections and in the inflammatory response of lung allograft rejection. To document macrophage activation within human lung allografts displaying various complications, we have investigated ICAM-1 expression in freshly isola...

journal_title：Annals of the New York Academy of Sciences

authors： Fattal-German M,Le Roy Ladurie F,Lecerf F,Berrih-Aknin S

更新日期：1996-10-31 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:In the light of results of clinical trials with immunoisolated human parathyroid tissue Ba2+-alginate capsules were developed that meet the requirements for long-term immunoisolated transplantation of (allogeneic and xenogeneic) cells and tissue fragments. Biocompatibility of the capsules was achieved by subjecting hi...

journal_title：Annals of the New York Academy of Sciences

authors： Zimmermann U,Thürmer F,Jork A,Weber M,Mimietz S,Hillgärtner M,Brunnenmeier F,Zimmermann H,Westphal I,Fuhr G,Nöth U,Haase A,Steinert A,Hendrich C

更新日期：2001-11-01 00:00:00

abstract：:Justice judgments are subjective by nature, and are influenced substantially by motivational processes. In the present contribution, two motives underlying justice judgments are examined: individualistic motives to evaluate solutions to social problems that benefit the self in material or immaterial ways as fair versu...

journal_title：Annals of the New York Academy of Sciences

authors： van Prooijen JW

更新日期：2013-09-01 00:00:00

abstract：:The results of this study indicate that the presence of plants did enhance TNT and TNB removal from IAAP groundwater. Most effective at 25 degrees C were reed canary grass, coontail and pondweed. Groundwater and plant tissue analyses indicate that in presence of the plants tested TNT is degraded to reduced by-products...

journal_title：Annals of the New York Academy of Sciences

authors： Best EP,Zappi ME,Fredrickson HL,Sprecher SL,Larson SL,Ochman M

更新日期：1997-11-21 00:00:00

abstract：:Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive. In the second, mutatio...

journal_title：Annals of the New York Academy of Sciences

authors： Knudson AG

更新日期：1997-12-29 00:00:00

abstract：:In keeping with the inflammatory paradigm of abdominal aortic aneurysm (AAA) pathophysiology, in vitro studies suggest that aneurysms secrete the proinflammatory cytokine interleukin-6 (IL-6). Circulating IL-6 levels are higher in patients with AAA with elevated circulating IL-6 an independent risk factor for cardiova...

journal_title：Annals of the New York Academy of Sciences

authors： Dawson J,Cockerill G,Choke E,Loftus I,Thompson MM

更新日期：2006-11-01 00:00:00

abstract：:Estrogens are represented by a diverse group of compounds. Within this large family of molecules are tissue-selective estrogens that have been classified as selective estrogen receptor modulators (SERMs). These compounds are characterized by the fact that they exhibit both estrogen agonist and antagonist activity depe...

journal_title：Annals of the New York Academy of Sciences

authors： Komm BS,Lyttle CR

更新日期：2001-12-01 00:00:00

abstract：:Despite the global transition to overnutrition, stunting affected approximately 159 million children worldwide in 2014, while an estimated 50 million children were wasted. India is an important front in the fight against malnutrition and is grappling with the coexistence of undernutrition, overnutrition, and micronutr...

journal_title：Annals of the New York Academy of Sciences

authors： Shankar B,Agrawal S,Beaudreault AR,Avula L,Martorell R,Osendarp S,Prabhakaran D,Mclean MS

更新日期：2017-05-01 00:00:00

abstract：:Antibodies to double-stranded desoxyribonucleic acid (dsDNA) and to the polymyositis/scleroderma (PM/Scl) complex are regarded as serological markers for systemic lupus erythematosus (SLE) and PM/Scl overlap syndrome, respectively. In a previous study, serum samples were identified that contained antibodies specific f...

journal_title：Annals of the New York Academy of Sciences

authors： Mahler M,Greidinger EL,Szmyrka M,Kromminga A,Fritzler MJ

更新日期：2007-08-01 00:00:00