Obesity, leptin, and Alzheimer's disease.

abstract：:Throughout this century in the United States, tension has existed between those who believe drug abuse is best combatted through the criminal justice system and those who emphasize a medical/public health model of prevention and treatment. In the last decade this debate has centered around the person of the pregnant a...

journal_title：Annals of the New York Academy of Sciences

authors： Chavkin W,Wise PH,Elman D

更新日期：1998-06-21 00:00:00

abstract：:Accelerated atherosclerosis occurs in patients with type III hyperlipoproteinemia and familial hypercholesterolemia. These genetic disorders focus attention on specific types of lipoproteins as being responsible for the development of accelerated coronary artery heart disease. The accumulation of chylomicron remnants ...

journal_title：Annals of the New York Academy of Sciences

authors： Weisgraber KH,Innerarity TL,Rall SC Jr,Mahley RW

更新日期：1990-01-01 00:00:00

abstract：:Time-resolved confocal microspectrofluorometry and fluorescence microscopy imaging were applied to monitor the cellular uptake of fluorescent-labeled oligonucleotides (ONs) delivered by a porphyrin molecule. The fate of porphyrin-ON complexes inside living cells has also been monitored. Due to intrinsic fluorescence o...

journal_title：Annals of the New York Academy of Sciences

authors： Praus P,Kocisová E,Mojzes P,Stepánek J,Seksek O,Sureau F,Turpin PY

更新日期：2008-01-01 00:00:00

abstract：:Our studies have shown that the acyclic nucleotide analogues PMEA and HPMPC are able to penetrate into cells and are then activated to mono- and diphosphate derivatives. The latter correspond to triphosphate analogues and presumably serve an important role in the biological activity exerted by these antiviral agents. ...

journal_title：Annals of the New York Academy of Sciences

authors： Bronson JJ,Ho HT,De Boeck H,Woods K,Ghazzouli I,Martin JC,Hitchcock MJ

更新日期：1990-01-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:The initial phase of vessel formation is the establishment of nascent endothelial tubes from mesodermal precursor cells. Development of the vascular epithelium is examined using the transcription factor TAL1 as a marker of endothelial precursor cells (angioblasts), and a functional assay based on intact, whole-mounted...

journal_title：Annals of the New York Academy of Sciences

authors： Drake CJ,Hungerford JE,Little CD

更新日期：1998-10-23 00:00:00

abstract：:A new autoimmune disease affecting the neuromuscular junction has been defined. Acquired neuromyotonia is associated with antibodies to voltage-gated potassium channels that act, at least in part, by reducing potassium channel function with resulting neuronal hyperactivity. This condition is quite frequently associate...

journal_title：Annals of the New York Academy of Sciences

authors： Vincent A,Jacobson L,Plested P,Polizzi A,Tang T,Riemersma S,Newland C,Ghorazian S,Farrar J,MacLennan C,Willcox N,Beeson D,Newsom-Davis J

更新日期：1998-05-13 00:00:00

abstract：:Adrenocortical androgens, including dehydroepiandrosterone (DHEA), are produced in the inner zone of the adrenal cortex that is in direct contact with the neural crest-derived catecholamine-producing chromaffin cells. DHEA has recently been identified as a crucial regulator of neuronal stem cell proliferation. Thus, D...

journal_title：Annals of the New York Academy of Sciences

authors： Ziegler CG,Sicard F,Sperber S,Ehrhart-Bornstein M,Bornstein SR,Krug AW

更新日期：2006-08-01 00:00:00

abstract：:Mass spectrometric analysis of the low-molecular-weight (LMW) range of the serum/plasma proteome is revealing the existence of large numbers of previously unknown peptides and protein fragments, predicted to be derived from circulating low-abundance proteins. While genomics and proteomics are the primary discovery res...

journal_title：Annals of the New York Academy of Sciences

authors： Byrum S,Montgomery CO,Nicholas RW,Suva LJ

更新日期：2010-03-01 00:00:00

abstract：:Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis. In the majority of cases, the Y chromosome-specific sequences are commonly used as a fetus-specific marker with a high risk of false-negative cases. We attempted to develop a sensitive and reliable...

journal_title：Annals of the New York Academy of Sciences

authors： Vecchione G,Tomaiuolo M,Sarno M,Colaizzo D,Petraroli R,Matteo M,Greco P,Grandone E,Margaglione M

更新日期：2008-08-01 00:00:00

abstract：:Osmotic opening of the blood-brain barrier (BBB) most likely is mediated by modification of interendothelial tight junctions, subsequent to shrinkage of cerebrovascular endothelial cells, and not by stimulation of transendothelial vesicular transport or by channel formation. This paper summarizes evidence for this con...

journal_title：Annals of the New York Academy of Sciences

authors： Rapoport SI,Robinson PJ

更新日期：1986-01-01 00:00:00

abstract：:Rapidly industrializing India is described by the International Monetary Fund as a young, disciplined, and vibrant economy with a projected growth of 6.7% for 2005. The total workforce of 397 million has only 7% of workers employed in the organized sector with construction, where asbestos exposure is prevalent, employ...

journal_title：Annals of the New York Academy of Sciences

authors： Joshi TK,Bhuva UB,Katoch P

更新日期：2006-09-01 00:00:00

abstract：:Sodium channels from rat and rabbit skeletal muscle have been isolated, characterized, and functionally reconstituted. These channel proteins closely resemble those purified from the eel electroplax and from rat brain. Work now in progress on the determination of the primary sequence of the 260 kDa subunit through the...

journal_title：Annals of the New York Academy of Sciences

authors： Barchi RL

更新日期：1986-01-01 00:00:00

abstract：:Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fe...

journal_title：Annals of the New York Academy of Sciences

authors： Oktem O,Oktay K

更新日期：2008-01-01 00:00:00

abstract：:Exposure of LLC-PK1 epithelial cell cultures to phorbol ester tumor promoters causes immediate translocation of protein kinase C-alpha (PKC-alpha) from cytosolic to membrane-associated compartments. With a very similar time course, a dramatic and sustained increase in tight junctional (paracellular) permeability occur...

journal_title：Annals of the New York Academy of Sciences

authors： Mullin JM,Laughlin KV,Ginanni N,Marano CW,Clarke HM,Peralta Soler A

更新日期：2000-01-01 00:00:00

abstract：:Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and t...

journal_title：Annals of the New York Academy of Sciences

authors： Candore G,Campagna AM,Cuppari I,Di Carlo D,Mineo C,Caruso C

更新日期：2007-09-01 00:00:00

abstract：:Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Pazianas M,Rhim AD,Weinberg AM,Su C,Lichtenstein GR

更新日期：2006-04-01 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:Increasing data indicate that polymorphic variants of nuclear loci can affect rate and quality of aging in humans. However, the mitochondrial genome is another good candidate, because of the central role played by mitochondrial genes in oxidative phosphorylation (OXPHOS) and cell metabolism. A characteristic of the mi...

journal_title：Annals of the New York Academy of Sciences

authors： de Benedictis G,Carrieri G,Varcasia O,Bonafè M,Franceschi C

更新日期：2000-06-01 00:00:00

abstract：:Comprehensive data mining of the scientific literature has become an increasing challenge. To address this challenge, Elsevier's Pathway Studio software uses the techniques of natural language processing to systematically extract specific biological information from journal articles and abstracts that is then used to ...

journal_title：Annals of the New York Academy of Sciences

authors： Cheadle C,Cao H,Kalinin A,Hodgkinson J

更新日期：2017-01-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative process characterized by progressive degeneration of the substantia nigra and concurrent loss of neuromelanin in these structures. The present hypothesis suggests that progression of Parkinson's disease may be reduced by enhancing the regional levels of neuroprotective factor...

journal_title：Annals of the New York Academy of Sciences

authors： Halabe Bucay A

更新日期：2008-11-01 00:00:00

abstract：:We isolated a eugenol-degrading bacterium, Pseudomonas fluorescens E118. This strain produced a novel enzyme, eugenol dehydrogenase, which catalyzes the conversion of eugenol into coniferyl alcohol. The enzyme was purified from the eugenol-induced cells of P. fluorescens E118. The purified enzyme appeared to be homoge...

journal_title：Annals of the New York Academy of Sciences

authors： Furukawa H,Nagasawa T

更新日期：1998-12-13 00:00:00

abstract：:The recent literature providing insights from neuroscience and evolutionary biology into how individuals perceive risky choice situations represents a "second wave" of findings that recapitulates as well as challenges the risk perception research begun in the 1980s, which relied on psychometric survey research. Gleani...

journal_title：Annals of the New York Academy of Sciences

authors： Finkel AM

更新日期：2008-04-01 00:00:00

abstract：:As recently as ten years ago, the nature of the T-cell receptor for antigen was a mystery, as was the precise role of histocompatibility molecules in antigen-presentation to T cells. Although T-cell receptors have now been cloned and crystal structures of MHC/peptide molecules exist, our understanding of the parameter...

journal_title：Annals of the New York Academy of Sciences

authors： Boniface JJ,Davis MM

更新日期：1995-09-07 00:00:00

abstract：:Propagation and prolongation of rapid neuronal discharge underlies the epilepsies. However, episodic focal rapid neuronal discharges limited to discrete nuclei and pathways of the amygdala-hippocampal-septal-hypothalamic networks are the language of physiologic message systems for endocrine regulation and reproductive...

journal_title：Annals of the New York Academy of Sciences

authors： Stevens JR

更新日期：1999-06-29 00:00:00

abstract：:Catecholamines (CAs) are significantly involved in the regulation of homeostasis of the organism at rest and especially during stressful situations. Stress induces increases in plasma CA (epinephrine and norepinephrine) levels and prolactin (PRL) release from the adenopituitary. We have recently observed that salsolin...

journal_title：Annals of the New York Academy of Sciences

authors： Bodnar I,Mravec B,Kubovcakova L,Fekete MI,Nagy GM,Kvetnansky R

更新日期：2004-06-01 00:00:00

abstract：:Fifty-eight contributors from 12 European and 2 American sarcoidosis centers have collaborated in a survey to define many questions concerning the use of 67Ga lung scan in sarcoidosis. The new quantitative scoring methods based on digital evaluation seem better in detecting lung activity. In 20.1% of untreated patient...

journal_title：Annals of the New York Academy of Sciences

authors： Rizzato G,Blasi A

更新日期：1986-01-01 00:00:00

abstract：:The Guillain Barré syndromes (GBS) are the world's leading cause of acute autoimmune neuromuscular paralysis. Understanding the pathophysiological events of GBS, and improving immunotherapies are fundamental to improving the clinical outcome. Recent research into GBS and the Miller Fisher syndrome (MFS) variant has fo...

journal_title：Annals of the New York Academy of Sciences

authors： Willison HJ,Plomp JJ

更新日期：2008-01-01 00:00:00

abstract：:This review will focus on the free radical signaling mechanism of preconditioning. The results from our laboratory as well as studies from other laboratories suggest that reactive oxygen species function as second messenger during myocardial adaptation to ischemia. This review provides evidence for the first time that...

journal_title：Annals of the New York Academy of Sciences

authors： Das DK,Engelman RM,Maulik N

更新日期：1999-06-30 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00