Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers.

abstract：:In amphibians, alpha-MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, th...

journal_title：Annals of the New York Academy of Sciences

authors： Vaudry H,Chartrel N,Desrues L,Galas L,Kikuyama S,Mor A,Nicolas P,Tonon MC

更新日期：1999-10-20 00:00:00

abstract：:The rates and properties of new mutations affecting fitness have implications for a number of outstanding questions in evolutionary biology. Obtaining estimates of mutation rates and effects has historically been challenging, and little theory has been available for predicting the distribution of fitness effects (DFE)...

journal_title：Annals of the New York Academy of Sciences

authors： Bataillon T,Bailey SF

更新日期：2014-07-01 00:00:00

abstract：:Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds induce status epilepticus (SE) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. Animal models of orga...

journal_title：Annals of the New York Academy of Sciences

authors： McCarren HS,McDonough JH Jr

更新日期：2016-06-01 00:00:00

abstract：:Membrane phospholipid metabolism is abnormal in Alzheimer's disease (AD) brain. Phosphatidylcholine and phosphatidylethanolamine levels are decreased as are choline and ethanolamine, while glycerophosphocholine (GPC) and glycerophosphoethanolamine are increased. To develop a rat model for these changes, we examined th...

journal_title：Annals of the New York Academy of Sciences

authors： Holmes TC,Nitsch RM,Erfurth A,Wurtman RJ

更新日期：1993-09-24 00:00:00

abstract：:Nur77, Nurr1, and NOR-1 form a subfamily (the NR4A/Nur subfamily) of transcription factors belonging to the family of nuclear receptors. In this report, we characterized the single member of such a subfamily in the amphioxus Branchiostoma floridae. Developmental expression analysis of AmphiNR4A showed transcripts limi...

journal_title：Annals of the New York Academy of Sciences

authors： Candiani S,Moronti L,Pestarino M

更新日期：2009-04-01 00:00:00

abstract：:tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...

journal_title：Annals of the New York Academy of Sciences

authors： Wainfan E,Maschio FA

更新日期：1975-08-08 00:00:00

abstract：:Accumulating epidemiological, clinical, and experimental evidence supports the conclusion of a critical role of epigenetic factors in immune programming. This understanding provides the basis for elucidating how the intricate interactions of the genome, epigenome, and transcriptome shape immune responses and maintain ...

journal_title：Annals of the New York Academy of Sciences

authors： Zouali M

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:As the second synapse in the central gustatory pathway of the rodent, the parabrachial nucleus of the pons (PbN) receives information about taste stimuli directly from the nucleus of the solitary tract (NTS). Data show that NTS cells amplify taste responses before transmitting taste-related signals to the PbN. NTS cel...

journal_title：Annals of the New York Academy of Sciences

authors： Di Lorenzo PM,Platt D,Victor JD

更新日期：2009-07-01 00:00:00

abstract：:9-beta-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) is an inhibitor both of DNA polymerase-alpha and -beta from noninfected rabbit kidney cells and of the DNA-dependent DNA polymerase induced by herpes simplex virus Type 1 (strain IES). The studies were performed with partially purified enzymes, and each of the...

journal_title：Annals of the New York Academy of Sciences

authors： Müller WE,Zahn RK,Bittlingmaier K,Falke D

更新日期：1977-03-04 00:00:00

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:Recent controversies in the existence of saturable binding of general anesthetics in brain tissues prompted a careful examination of specific binding of anesthetics to neural receptors. We examined the binding of both local and general anesthetics using electron spin resonance and radioligand criteria. Our results sug...

journal_title：Annals of the New York Academy of Sciences

authors： Lin L,Koblin DD,Wang HH

更新日期：1991-01-01 00:00:00

abstract：:Vitamin E deficiency in rats increased the sensitivity of liver and muscle mitochondria to damage during incubation at various temperatures, irradiation with visible light, or steady-state respiration with substrates. In all cases, vitamin E-deficient mitochondria exhibited increased lipid peroxidation, reduced transm...

journal_title：Annals of the New York Academy of Sciences

authors： Quintanilha AT,Packer L,Davies JM,Racanelli TL,Davies KJ

更新日期：1982-01-01 00:00:00

abstract：:Seleno-glutathione peroxidase (GSHPx) is considered to be the major enzymatic activity in charge of removing excess cytosolic and mitochondrial H2O2 in most tissues including brain. Intracellular GSHPx activity is therefore hypothesized to be one important factor that contributes to minimize hydroxyl radical formation...

journal_title：Annals of the New York Academy of Sciences

authors： Mirault ME,Tremblay A,Furling D,Trepanier G,Dugre F,Puymirat J,Pothier F

更新日期：1994-11-17 00:00:00

abstract：:Acylated aldose dialkyl dithioacetals with bromine undergo replacement of one alkylthio group by bromine. These unstable bromides react, as by fusion with 2,4-bis(trimethylsilyloxy)pyrimidine, to give acylated 1-(pyrimidin-1-yl) derivatives that upon saponification afford acyclic sugar nucleoside analogues, some as se...

journal_title：Annals of the New York Academy of Sciences

authors： Horton D,Baker DC,Kokrady SS

更新日期：1975-08-08 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:It is hypothesized that a phonemic processing deficit is a primary causal factor in the reading problems of many children with developmental dyslexia. An instructional model which emphasizes phonics instruction as a key in the treatment of children with reading disorders is presented. Procedures for the application of...

journal_title：Annals of the New York Academy of Sciences

authors： Richardson E

更新日期：1984-01-01 00:00:00

abstract：:Significant state and national policy initiatives are focusing on strategies for financing and structuring the delivery of evidence-based services for children. These initiatives reflect, in part, an increased awareness of and respect for scientific standards about effective treatments and services. At the same time, ...

journal_title：Annals of the New York Academy of Sciences

authors： Hoagwood K

更新日期：2003-12-01 00:00:00

abstract：:Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selective delivery of therapeutic agents to the central nervous system. Primary cultures of brain microvessel endothelial cells offer a ...

journal_title：Annals of the New York Academy of Sciences

authors： Audus KL,Borchardt RT

更新日期：1987-01-01 00:00:00

abstract：:Henry Kandrup wrote prolifically on the problem of relaxation of stellar systems. His picture of relaxation was significantly more refined than the standard description in terms of phase mixing and violent relaxation. In this article, I summarize Henry's work in this and related areas. ...

journal_title：Annals of the New York Academy of Sciences

authors： Merritt D

更新日期：2005-06-01 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

journal_title：Annals of the New York Academy of Sciences

authors： Anji A,Shaik KA,Kumari M

更新日期：2003-05-01 00:00:00

abstract：:The availability of computer-controlled artificial hearts, kidneys, and lungs, as well as the possibility of implanting human embryos in ex vivo uterus models or an artificial endometrium, presents new perspectives for creating an artificial uterus. Survival rates have also improved, with fetuses surviving from as ear...

journal_title：Annals of the New York Academy of Sciences

authors： Bulletti C,Palagiano A,Pace C,Cerni A,Borini A,de Ziegler D

更新日期：2011-03-01 00:00:00

abstract：:The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...

journal_title：Annals of the New York Academy of Sciences

authors： LeJeune KE,Dravis BC,Yang F,Hetro AD,Doctor BP,Russell AJ

更新日期：1998-12-13 00:00:00

abstract：:Previous reports have shown that there are age-related reductions in muscarinic receptor (mAChR) sensitivity to agonist stimulation. Our research has elucidated the mechanisms involved in this loss. These studies have shown that this decline is the result of decreases in mAChR concentration, reductions in the number o...

journal_title：Annals of the New York Academy of Sciences

authors： Joseph JA,Cutler R,Roth GS

更新日期：1993-09-24 00:00:00

abstract：:Recent cross-cultural studies of child development reveal that child rearing, while strikingly culturally variable, is everywhere designed to make the child's experience of important lessons constant, to link those lessons to emotional arousal, and to connect them to evaluations of the child's goodness and badness. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn N

更新日期：2003-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a major source of pain and disability worldwide with no effective medical therapy due to poor understanding of its pathogenesis. Transforming growth factor β (TGF-β) has been reported to play a role in subchondral bone pathology and articular cartilage degeneration during the progression of OA. ...

journal_title：Annals of the New York Academy of Sciences

authors： Xie L,Tintani F,Wang X,Li F,Zhen G,Qiu T,Wan M,Crane J,Chen Q,Cao X

更新日期：2016-07-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:The Caribbean Amblyomma Program has been operational for 8 years. However, owing to funding availability, some islands did not commence eradication activities until late 1997. During the past 2 years, 6 of the 9 islands (St. Kitts, St. Lucia, Anguilla, Montserrat, Barbados, and Dominica) under the program have attaine...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram R,Indar L,Eddi C,George J

更新日期：2004-10-01 00:00:00

abstract：:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In th...

journal_title：Annals of the New York Academy of Sciences

authors： Iwai K,Takahashi S

更新日期：1976-01-01 00:00:00