Tight-junctional modification as the basis of osmotic opening of the blood-brain barrier.

abstract：:GEM 231 is a second-generation antisense oligonucleotide targeted against the RIalpha regulatory subunit of cAMP-dependent protein kinase type I (PKA-I). Excessive expression of PKA-I is associated with cell proliferation and transformation, and increased levels of secreted extracellular PKA (ECPKA) are found in the s...

journal_title：Annals of the New York Academy of Sciences

authors： Mani S,Goel S,Nesterova M,Martin RM,Grindel JM,Rothenberg ML,Zhang R,Tortora G,Cho-Chung YS

更新日期：2003-12-01 00:00:00

abstract：:Flavonoids and phenolic acids are widely distributed in higher plants and form part of the human diet. Recent interest in these substances has been stimulated by the potential health benefits arising from the antioxidant activity of these polyphenolic compounds. This review outlines the basic chemistry, biosynthesis, ...

journal_title：Annals of the New York Academy of Sciences

authors： Croft KD

更新日期：1998-11-20 00:00:00

abstract：:Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member...

journal_title：Annals of the New York Academy of Sciences

authors： Allez M,Brimnes J,Shao L,Dotan I,Nakazawa A,Mayer L

更新日期：2004-12-01 00:00:00

abstract：:The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

journal_title：Annals of the New York Academy of Sciences

authors： Mundy NI,Kelly J,Theron E,Hawkins K

更新日期：2003-06-01 00:00:00

abstract：:Animal studies have already shown the possibility to modulate insulin action by changing not only the amount of total fat, but also the type of fat. In these studies, saturated fat significantly increased insulin resistance, long- and short-chain omega(3) fatty acids significantly improved it, whereas the effects of m...

journal_title：Annals of the New York Academy of Sciences

authors： Rivellese AA,De Natale C,Lilli S

更新日期：2002-06-01 00:00:00

abstract：:A body of information obtained by experiments with intact tissues, isolated cells, and sarcolemmal vesicles indicates, beyond a reasonable doubt, that a specific Na(+)-Ca2+ exchange system exists in vascular smooth muscle. However, its role in the regulation of cytosolic free-Ca2+ concentration and cell tension under ...

journal_title：Annals of the New York Academy of Sciences

authors： Matlib MA

更新日期：1991-01-01 00:00:00

abstract：:Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

journal_title：Annals of the New York Academy of Sciences

authors： Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

更新日期：2009-04-01 00:00:00

abstract：:Maize (Zea mays), also called corn, is believed to have originated in central Mexico 7000 years ago from a wild grass, and Native Americans transformed maize into a better source of food. Maize contains approximately 72% starch, 10% protein, and 4% fat, supplying an energy density of 365 Kcal/100 g and is grown throug...

journal_title：Annals of the New York Academy of Sciences

authors： Ranum P,Peña-Rosas JP,Garcia-Casal MN

更新日期：2014-04-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:Hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis is often observed in association with and even prior to the onset of major depression. It is presently unclear (1) which molecular and cellular processes contribute to hyperactivity of parvocellular hypothalamic neurons (key regulators of the HPA system) an...

journal_title：Annals of the New York Academy of Sciences

authors： Joëls M,Verkuyl JM,Van Riel E

更新日期：2003-12-01 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:The surprising discovery in 1990 that estrogen modulates hippocampal structural plasticity launched a whole new field of scientific inquiry. Over the past two decades, estrogen-induced spinogenesis has been described in several brain areas involved in cognition in a number of species, in both sexes and on multiple tim...

journal_title：Annals of the New York Academy of Sciences

authors： Dumitriu D,Rapp PR,McEwen BS,Morrison JH

更新日期：2010-08-01 00:00:00

abstract：:We studied the role of the peptide substance P, signaling through the neurokinin-1 (NK-1) receptor, on methamphetamine-induced loss of dopamine transporter sites, a well-documented marker of toxicity in the striatum of the mouse brain, because this peptide is under dynamic regulation by the neurotransmitter dopamine. ...

journal_title：Annals of the New York Academy of Sciences

authors： Yu J,Allison S,Ibrahim D,Cadet JL,Angulo JA

更新日期：2002-06-01 00:00:00

abstract：:In the frame of the free-radical hypothesis of aging and literature data on increased life span of mated animals, we evaluated brain, kidney, and liver lipid peroxidation in C57Bl/6J mice of various ages and compared lipid peroxidation activity in mated and non-mated mice of both genders. An aging-associated increase ...

journal_title：Annals of the New York Academy of Sciences

authors： Oxenkrug GF,Requintina PJ

更新日期：2003-05-01 00:00:00

abstract：:Approximately 15% of pregnant women vape electronic cigarettes (e-cigarettes), exposing the fetus to a range of toxic compounds, including nicotine and by-products of e-cigarette liquid (e-liquid) pyrolysis. Owing to the recent emergence of these products, research mainly focuses on immediate users, and not on in uter...

journal_title：Annals of the New York Academy of Sciences

authors： Li G,Chan YL,Wang B,Saad S,George J,Oliver BG,Chen H

更新日期：2020-09-01 00:00:00

abstract：:Cotyledons of dark-grown watermelon seedlings contain during the first period of germination, 4 and later 5 MDH isoenzymes. Whereas isoenzymes I, II, and IV belong to the cytosol, isoenzyme III is confined to the mitochondria (mMDH) and isoenzyme V to the glyoxysomes (gMDH). The organelle-bound MDHs were purified to h...

journal_title：Annals of the New York Academy of Sciences

authors： Hock B,Gietl C

更新日期：1982-01-01 00:00:00

abstract：:Legally, women, Native Americans, and African-Americans were defined by the American Constitution as inferior. The pragmatists gradually showed that all selves are equal. These ideas helped the minorities to attain nearly full legal status. But economic status is going in the other direction, toward inequality. It thr...

journal_title：Annals of the New York Academy of Sciences

authors： Wiley N

更新日期：2011-10-01 00:00:00

abstract：:The amygdala and orbitofrontal cortex (OFC) are often thought of as components of a neural circuit that assigns affective significance--or value--to sensory stimuli so as to anticipate future events and adjust behavioral and physiological responses. Much recent work has been aimed at understanding the distinct contrib...

journal_title：Annals of the New York Academy of Sciences

authors： Salzman CD,Paton JJ,Belova MA,Morrison SE

更新日期：2007-12-01 00:00:00

abstract：:I2-imidazoline receptors (I2-IR) are characterized by their high affinity for imidazolines and guanidines and medium affinity for imidazolidines. The differential recognition of I2-IR by amiloride led to subtype these sites as amiloride-sensitive (I2A-IR) and amiloride-insensitive (I2B-IR). I2-IR labeled with [3H]idaz...

journal_title：Annals of the New York Academy of Sciences

authors： Olmos G,Alemany R,Boronat MA,García-Sevilla JA

更新日期：1999-06-21 00:00:00

abstract：:Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

journal_title：Annals of the New York Academy of Sciences

authors： Breckenridge RT

更新日期：1975-01-20 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:Current tuberculosis (TB) therapies take too long and the regimens are complex and subject to adverse effects and drug-drug interactions with concomitant medications. The emergence of drug-resistant TB strains exacerbates the situation. Drug discovery for TB has resurged in recent years, generating compounds (hits) wi...

journal_title：Annals of the New York Academy of Sciences

authors： Mdluli K,Kaneko T,Upton A

更新日期：2014-09-01 00:00:00

abstract：:Cognitive neuroscience research has traditionally overlooked half of the population. Arguing that variability in ovarian hormones confounds empirical findings, girls and women have been excluded from research for decades. But times are changing. This review summarizes historical trends that have led to a knowledge gap...

journal_title：Annals of the New York Academy of Sciences

authors： Beltz AM,Moser JS

更新日期：2020-03-01 00:00:00

abstract：:The amyloid-beta protein (A beta), strongly implicated in the etiology of Alzheimer's disease (AD), is formed from the amyloid-beta precursor protein (APP) through sequential proteolysis by beta- and gamma-secretases. Cleavage by gamma-secretase takes place within the middle of the single transmembrane region of APP a...

journal_title：Annals of the New York Academy of Sciences

authors： Moore CL,Diehl TS,Selkoe DJ,Wolfe MS

更新日期：2000-01-01 00:00:00

abstract：:Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

journal_title：Annals of the New York Academy of Sciences

authors： Smith CJ,Ajdukiewicz A,Kelleher PC

更新日期：1983-01-01 00:00:00

abstract：:Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

journal_title：Annals of the New York Academy of Sciences

authors： Del Bello B,Valentini MA,Comporti M,Maellaro E

更新日期：2003-12-01 00:00:00

abstract：:Metabolic disorders present a public health challenge of staggering proportions. In diabetes, there is an urgent need to better understand disease heterogeneity, clinical trajectories, and related comorbidities. A pressing and timely question is whether we are ready for precision medicine in diabetes. Some biological ...

journal_title：Annals of the New York Academy of Sciences

authors： Merino J,Florez JC

更新日期：2018-01-01 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

journal_title：Annals of the New York Academy of Sciences

authors： Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：:Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was ad...

journal_title：Annals of the New York Academy of Sciences

authors： Soffritti M,Belpoggi F,Lambertin L,Lauriola M,Padovani M,Maltoni C

更新日期：2002-12-01 00:00:00