Tuberculosis drug discovery and emerging targets.

abstract：:Cellulose degradation is a rare trait in bacteria. However, the truly cellulolytic bacteria are extremely efficient hydrolyzers of plant cell wall polysaccharides, especially those in thermophilic anaerobic ecosystems. Clostridium stercorarium, a thermophilic ubiquitous soil dweller, has a simple cellulose hydrolyzing...

journal_title：Annals of the New York Academy of Sciences

authors： Zverlov VV,Schwarz WH

更新日期：2008-03-01 00:00:00

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:The Ras proteins, which regulate intracellular signaling by a cyclic process involving interconversion between active GTP-bound and inactive GDP-bound states, play an essential role in controlling the activity of several crucial signaling pathways regulating normal cellular proliferation. Mutational activation of RAS ...

journal_title：Annals of the New York Academy of Sciences

authors： Colombo S,Peri F,Tisi R,Nicotra F,Martegani E

更新日期：2004-12-01 00:00:00

abstract：:Reproduction usually is characterized by a mean-population fecundity pattern. Such a pattern has a maximum at earlier ages and a subsequent gradual decline in egg production. It is shown that individual fecundity trajectories do not follow such a pattern. In particular, the regular individual fecundity pattern has no ...

journal_title：Annals of the New York Academy of Sciences

authors： Novoseltsev VN,Arking R,Carey JR,Novoseltseva JA,Yashin AI

更新日期：2004-06-01 00:00:00

abstract：:In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extra...

journal_title：Annals of the New York Academy of Sciences

authors： Christakos S,Hewison M,Gardner DG,Wagner CL,Sergeev IN,Rutten E,Pittas AG,Boland R,Ferrucci L,Bikle DD

更新日期：2013-05-01 00:00:00

abstract：:9-beta-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) is an inhibitor both of DNA polymerase-alpha and -beta from noninfected rabbit kidney cells and of the DNA-dependent DNA polymerase induced by herpes simplex virus Type 1 (strain IES). The studies were performed with partially purified enzymes, and each of the...

journal_title：Annals of the New York Academy of Sciences

authors： Müller WE,Zahn RK,Bittlingmaier K,Falke D

更新日期：1977-03-04 00:00:00

abstract：:To evaluate the effect of Lactobacillus casei on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day -2 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animal...

journal_title：Annals of the New York Academy of Sciences

authors： Bautista CR,Alvarez JA,Mosqueda JJ,Falcon A,Ramos JA,Rojas C,Figueroa JV,Ku M

更新日期：2008-12-01 00:00:00

abstract：:Although smell loss has several potential etiologies (e.g., head trauma, allergic rhinitis, and enlarged adenoids) that are common among children, studies evaluating the prevalence of olfactory dysfunction in the pediatric population are rare. Several challenges confront the clinician or researcher hoping to evaluate ...

journal_title：Annals of the New York Academy of Sciences

authors： Dalton P,Mennella JA,Cowart BJ,Maute C,Pribitkin EA,Reilly JS

更新日期：2009-07-01 00:00:00

abstract：:Gene therapy for beta-globinopathies, particularly beta-thalassemia and sickle cell anemia, hold much promise for the future, as a one time cure for these common and debilitating disorders. Correction of the beta-globinopathies using lentivirus vectors (LV) carrying the beta- or gamma-globin genes and elements of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Perumbeti A,Malik P

更新日期：2010-08-01 00:00:00

abstract：:Justice judgments are subjective by nature, and are influenced substantially by motivational processes. In the present contribution, two motives underlying justice judgments are examined: individualistic motives to evaluate solutions to social problems that benefit the self in material or immaterial ways as fair versu...

journal_title：Annals of the New York Academy of Sciences

authors： van Prooijen JW

更新日期：2013-09-01 00:00:00

abstract：:When conceptualized within a developmental systems theoretical framework, resilience involves mutually beneficial, reciprocally influential relations between a person and his or her context. The key features of developmental systems theory, which stress the plasticity of these relations, lead to an optimistic view of ...

journal_title：Annals of the New York Academy of Sciences

authors： Lerner RM

更新日期：2006-12-01 00:00:00

abstract：:Long-term exposure to cadmium (Cd) induces perturbation of kidney proximal tubular epithelial cells. Mitochondrial dysfunction in renal cortical cells may contribute to the pathogenesis of Cd-induced nephropathy. In this study, we examined the accumulation of mitochondrial DNA (mtDNA) with a large deletion and cellula...

journal_title：Annals of the New York Academy of Sciences

authors： Takaki A,Jimi S,Segawa M,Iwasaki H

更新日期：2004-04-01 00:00:00

abstract：:Methamphetamine (METH) is a widely used "club drug" that produces neural damage in the brain, including the loss of some neurons. METH-induced striatal neuronal loss has been attenuated by pretreatment with the neurokinin-1 receptor antagonist WIN-51,708 in mice. Using a histologic method, we have observed the interna...

journal_title：Annals of the New York Academy of Sciences

authors： Wang J,Xu W,Ali SF,Angulo JA

更新日期：2008-10-01 00:00:00

abstract：:In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance...

journal_title：Annals of the New York Academy of Sciences

authors： Ambrus JL,Ambrus CM,Odake K,Mink IB,Shields R,Warner W,Bishop C,Tritsch GL,Golden G,Mittelman A

更新日期：1975-08-08 00:00:00

abstract：:Acetogens utilize the acetyl-CoA Wood-Ljungdahl pathway as a terminal electron-accepting, energy-conserving, CO(2)-fixing process. The decades of research to resolve the enzymology of this pathway (1) preceded studies demonstrating that acetogens not only harbor a novel CO(2)-fixing pathway, but are also ecologically ...

journal_title：Annals of the New York Academy of Sciences

authors： Drake HL,Gössner AS,Daniel SL

更新日期：2008-03-01 00:00:00

abstract：:Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous high-amplitude rhythmical electroencephalography (EEG) spike activity an...

journal_title：Annals of the New York Academy of Sciences

authors： Dhir A,Bruun DA,Guignet M,Tsai YH,González E,Calsbeek J,Vu J,Saito N,Tancredi DJ,Harvey DJ,Lein PJ,Rogawski MA

更新日期：2020-11-01 00:00:00

abstract：:Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds induce status epilepticus (SE) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. Animal models of orga...

journal_title：Annals of the New York Academy of Sciences

authors： McCarren HS,McDonough JH Jr

更新日期：2016-06-01 00:00:00

abstract：:Internuclear ophthalmoparesis (INO) is the most common saccadic eye movement disorder observed in patients with multiple sclerosis (MS). It is characterized by slowing of the adducting eye during horizontal saccades, and most commonly results from a demyelinating lesion in the medial longitudinal fasciculus (MLF) with...

journal_title：Annals of the New York Academy of Sciences

authors： Frohman TC,Davis SL,Frohman EM

更新日期：2011-09-01 00:00:00

abstract：:The acquisition of both speech and music uses general principles: learners extract statistical regularities present in the environment. Yet, individuals who suffer from congenital amusia (commonly called tone-deafness) have experienced lifelong difficulties in acquiring basic musical skills, while their language abili...

journal_title：Annals of the New York Academy of Sciences

authors： Peretz I,Saffran J,Schön D,Gosselin N

更新日期：2012-04-01 00:00:00

abstract：:At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at lea...

journal_title：Annals of the New York Academy of Sciences

authors： Berger MR,Tsoneva I,Konstantinov SM,Eibl H

更新日期：2003-12-01 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:We previously showed that pituitary adenylate cyclase-activating polypeptide (PACAP) potently stimulates insulin secretion in vivo in mice without altering glucose disposal. Such a combination of results would be explained if epinephrine released by PACAP counteracts the action of insulin and, therefore, that the gluc...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B,Filipsson K

更新日期：2000-01-01 00:00:00

abstract：:A cross-sectional study of raw meat samples from the local meat market of Kathmandu Metropolitan City was carried out during September 2002 to May 2003 with special emphasis on isolation and identification of Salmonella bacteria. A total of 123 raw meat samples (55 chicken, 37 buffalo, and 31 goat) were collected and ...

journal_title：Annals of the New York Academy of Sciences

authors： Maharjan M,Joshi V,Joshi DD,Manandhar P

更新日期：2006-10-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide, exerts a variety of physiological functions through three types of G protein-coupled receptors, PAC1, VPAC1, and VAPC2. Characterization of the molecular forms of PAC1 in mouse heart revealed the presence of four types of variant r...

journal_title：Annals of the New York Academy of Sciences

authors： Ushiyama M,Sugawara H,Inoue K,Kangawa K,Yamada K,Miyata A

更新日期：2006-07-01 00:00:00

abstract：:Exosomes are nanovesicles secreted from cells that play key roles in intercellular communication. They carry unique content derived from parental cells and are capable of transferring this cargo between cells. The role and function of exosomes largely depends on the origin and functional status of the parental cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cobelli NJ,Leong DJ,Sun HB

更新日期：2017-12-01 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:Significant advances have recently been made in understanding the regulation of Ca(2+)-ATPase by phospholamban and in modeling their structures. However, these insights would be furthered by determining the 3-D structure of both proteins within the membrane, thus revealing the structural basis for their interaction. T...

journal_title：Annals of the New York Academy of Sciences

authors： Young HS,Reddy LG,Jones LR,Stokes DL

更新日期：1998-09-16 00:00:00

abstract：:Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimula...

journal_title：Annals of the New York Academy of Sciences

authors： Santen R,Cavalieri E,Rogan E,Russo J,Guttenplan J,Ingle J,Yue W

更新日期：2009-02-01 00:00:00

abstract：:Differentiation of embryonic stem (ES) cells in vitro yields abundant hematopoietic progenitors, but achieving stable hematopoietic engraftment of irradiated mice has proven difficult, begging the question of whether ES cells give rise to hematopoietic stem cells in vitro, and limiting the application of ES cells as e...

journal_title：Annals of the New York Academy of Sciences

authors： Daley GQ

更新日期：2003-05-01 00:00:00