Ovarian hormones: a long overlooked but critical contributor to cognitive brain structures and function.

abstract：:The cardiac myofilaments consist of a highly ordered assembly of proteins that collectively generate force in a calcium-dependent manner. Defects in myofilament function and its regulation have been implicated in various forms of acquired and inherited human heart disease. For example, during cardiac ischemia, cardiac...

journal_title：Annals of the New York Academy of Sciences

authors： Day S,Davis J,Westfall M,Metzger J

更新日期：2006-10-01 00:00:00

abstract：:Based on the relation found to exist between low CSF 5-HIAA and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-HT metabolism is related to (auto)aggression, rather than to depression. We chall...

journal_title：Annals of the New York Academy of Sciences

authors： Van Praag HM,Plutchik R,Conte H

更新日期：1986-01-01 00:00:00

abstract：:The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis...

journal_title：Annals of the New York Academy of Sciences

authors： Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

更新日期：2006-05-01 00:00:00

abstract：:Recent immunologic studies have provided important new information about the nature of AHF deficiency diseases and the structure and synthesis of this protein. They provide, moreover, a considerably improved ability to identify the carrier state in hemophilia A. Additional progress may be possible in the identificatio...

journal_title：Annals of the New York Academy of Sciences

authors： Hoyer LW,Rick ME

更新日期：1975-01-20 00:00:00

abstract：:The genomic era has fueled a rapid emergence of new information at the molecular level with a great potential for developing innovative approaches to detection, risk assessment, and management of oral cancers and premalignant disease. As yet, however, little research has been done on complementary approaches that woul...

journal_title：Annals of the New York Academy of Sciences

authors： Rosin MP,Poh CF,Guillard M,Williams PM,Zhang L,MacaUlay C

更新日期：2007-03-01 00:00:00

abstract：:SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

journal_title：Annals of the New York Academy of Sciences

authors： Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

更新日期：2009-01-01 00:00:00

abstract：:Modern contraceptive methods represent more than a technical advance: they are the instrument of a true social revolution-the "first reproductive revolution" in the history of humanity, an achievement of the second part of the 20th century, when modern, effective methods became available. Today a great diversity of te...

journal_title：Annals of the New York Academy of Sciences

authors： Benagiano G,Bastianelli C,Farris M

更新日期：2006-12-01 00:00:00

abstract：:Most measurement devices for bioimpedance spectroscopy are coupled to the measured object (tissue) via electrodes. At frequencies > 500 kHz, they suffer from artifacts due to stray capacitances between electrode leads as well as between the ground and object. The noninvasive measurement of the brain conductivity is ha...

journal_title：Annals of the New York Academy of Sciences

authors： Scharfetter H,Ninaus W,Puswald B,Petrova GI,Kovachev D,Hutten H

更新日期：1999-04-20 00:00:00

abstract：:Lateral interaction of c-erbB family receptors resulting in dimer formation is the key event initiating signal transduction. Consequently cross-activation and intracellular signaling is triggered with immediate impact on cell proliferation, migration, cell survival, and differentiation. In order to elucidate the conne...

journal_title：Annals of the New York Academy of Sciences

authors： Diermeier-Daucher S,Hasmann M,Brockhoff G

更新日期：2008-01-01 00:00:00

abstract：:Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

journal_title：Annals of the New York Academy of Sciences

authors： Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

journal_title：Annals of the New York Academy of Sciences

authors： Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

更新日期：1995-07-12 00:00:00

abstract：:Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

journal_title：Annals of the New York Academy of Sciences

authors： Davis MM,McHeyzer-Williams M,Chien YH

更新日期：1995-07-07 00:00:00

abstract：:The success of embryonic implantation relies on an ideal cross-talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differen...

journal_title：Annals of the New York Academy of Sciences

authors： Aghajanova L

更新日期：2004-12-01 00:00:00

abstract：:This study surveyed serum concentrations of vitamins, electrolytes, and trace elements in subjects seropositive for HIV-1 by ELISA and confirmatory Western blot. Thirty subjects (26 males, 4 females) were recruited at a hospital clinic. Seventeen were classified as having mild or severe ARC (AIDS-related complex), 7 h...

journal_title：Annals of the New York Academy of Sciences

authors： Bogden JD,Baker H,Frank O,Perez G,Kemp F,Bruening K,Louria D

更新日期：1990-01-01 00:00:00

abstract：:Several reports addressed the issue of how the alternative splicing of exon 7 and 8 in the APP pre-mRNA is regulated in different tissues. Of special interest here was the potential involvement of exon 7 containing APP splice isoforms, since this exon codes for a serine protease inhibitor and is therefore of putative ...

journal_title：Annals of the New York Academy of Sciences

authors： Sandbrink R,Banati R,Masters CL,Beyreuther K,König G

更新日期：1993-09-24 00:00:00

abstract：:Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular wall cells but also ...

journal_title：Annals of the New York Academy of Sciences

authors： Pattillo CB,Fang K,Terracciano J,Kevil CG

更新日期：2010-10-01 00:00:00

abstract：:The thymus produces several putative thymic hormones: thymosin alpha 1, thymulin, and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T cells in the periphery, thus maintaining their commitment to the T cell system. These endocrine influences decline with age and are ass...

journal_title：Annals of the New York Academy of Sciences

authors： Hadden JW,Malec PH,Coto J,Hadden EM

更新日期：1992-12-26 00:00:00

abstract：:Wisdom is a special kind of virtue. It is not to be identified with any outstanding cognitive ability-like having a prodigious memory or knowing a lot. Rather it consists in seeing what is most important and most valuable, either within a particular domain or in life as a whole. In the life of a wise person, that insi...

journal_title：Annals of the New York Academy of Sciences

authors： Kitcher P

更新日期：2016-11-01 00:00:00

abstract：:Seleno-glutathione peroxidase (GSHPx) is considered to be the major enzymatic activity in charge of removing excess cytosolic and mitochondrial H2O2 in most tissues including brain. Intracellular GSHPx activity is therefore hypothesized to be one important factor that contributes to minimize hydroxyl radical formation...

journal_title：Annals of the New York Academy of Sciences

authors： Mirault ME,Tremblay A,Furling D,Trepanier G,Dugre F,Puymirat J,Pothier F

更新日期：1994-11-17 00:00:00

abstract：:We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the brain from a variety of insults including stroke, epilepsy, and other related insults. While the mechanism of this protection has largely been thought to be due to their chaperone functions (i.e., preventing abnormal pro...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Liu J,Zheng Z,Vexler ZS,Lee JE,Giffard RG

更新日期：2005-08-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) participates in the regulation of endochondral bone development. After the cartilage mold is established in fetal life, perichondrial cells and chondrocytes at the ends of the mold synthesize PTHrP. This ligand then acts on PTH/PTHrP receptors on chondrocytes. As chondrocyte...

journal_title：Annals of the New York Academy of Sciences

authors： Kronenberg HM

更新日期：2006-04-01 00:00:00

abstract：:The expression levels of GAP-43 and MAP-2, two proteins involved, respectively, in axonal and dendritic remodeling, in control adult (11 months), old (24 months), and vitamin E-deficient (11 months) rats were evaluated. mRNA levels were determined by means of a quantitative in situ hybridization procedure in subregion...

journal_title：Annals of the New York Academy of Sciences

authors： Casoli T,Di Stefano G,Delfino A,Fattoretti P,Bertoni-Freddari C

更新日期：2004-06-01 00:00:00

abstract：:Adults with better jobs enjoy better health: job title was, in fact, the social gradient metric first used to study the relationship between social class and chronic disease etiology, a core finding now replicated in most developed countries. What has been less well proved is whether this correlation is causal, and if...

journal_title：Annals of the New York Academy of Sciences

authors： Clougherty JE,Souza K,Cullen MR

更新日期：2010-02-01 00:00:00

abstract：:MRI assessment of myocardial iron and function has revolutionized the treatment of thalassemia major patients. While knowledge of somatic iron stores is vital for iron chelation management, it does not adequately monitor cardiac risk. MRI monitoring of cardiac T2* allows preclinical recognition of myocardial iron, str...

journal_title：Annals of the New York Academy of Sciences

authors： Wood JC,Noetzli L

更新日期：2010-08-01 00:00:00

abstract：:The vertebrate neuromuscular junction (NMJ) is a "tripartite" synapse, composed of three cellular elements: the presynaptic nerve terminal, the postsynaptic specialization, and synapse-associated glial cells, called perisynaptic Schwann cells (PSCs; also called terminal Schwann cells). During development, PSCs grow be...

journal_title：Annals of the New York Academy of Sciences

authors： Feng Z,Ko CP

更新日期：2008-01-01 00:00:00

abstract：:Hyperoxia and alkalemia, as a result of pulmonary hyperventilation and elevation of plasma DNA (pDNA), are seen during the first 24 h after ischemic stroke. In this study we have examined the correlation between pDNA and these blood parameters in health and stroke. Acid-base equilibrium, oxygen status, hemoglobin affi...

journal_title：Annals of the New York Academy of Sciences

authors： Konorova IL,Veiko NN,Novikov VE

更新日期：2008-08-01 00:00:00

abstract：:Whole and nonadherent Peyer's patch cells were shown to present antigen to cloned antigen specific T-cells, albeit less efficiently than spleen cells. Unlike spleen cells, adherent PP cells did not present antigen, and PP lacked cells with classical dendritic morphology. The antigen presenting and MLR-stimulating cell...

journal_title：Annals of the New York Academy of Sciences

authors： Tomasi TB,Barr WG,Challacombe SJ,Curran G

更新日期：1983-06-30 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is primarily a motor disorder, and its pathogenesis is multifactorial. As a consequence, treatment should be able to address the underlying pathophysiology. Proton pump inhibitors (PPIs) are the mainstay of medical therapy for GERD, but these drugs only provide the control of sym...

journal_title：Annals of the New York Academy of Sciences

authors： Scarpignato C,Sloan JA,Wang DH,Hunt RH

更新日期：2020-12-01 00:00:00

abstract：:Rhythm is fundamental to every motor activity. Neural and physiological mechanisms that underlie rhythmic cognition, in general, and rhythmic pattern generation, in particular, are evolutionarily ancient. As speech production is a kind of motor activity, investigating speech rhythm can provide insight into how general...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M

更新日期：2019-10-01 00:00:00

abstract：:2-Phenylindoles and isosteric structures such as benzo[b]furans and benzo[b]thiophenes were used as estrogen receptor binding moiety for the syntheses of new nonsteroidal antiestrogens. The antiestrogenic potency was considerably enhanced following the introduction of polar functional groups into the side chain in pos...

journal_title：Annals of the New York Academy of Sciences

authors： Von Angerer E,Biberger C,Leichtl S

更新日期：1995-06-12 00:00:00