Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.

Abstract:

:Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular wall cells but also influenced by simultaneously occurring inflammatory responses. Our laboratory has discovered that pharmacological treatment of permanent tissue ischemia with dipyridamole significantly augments ischemic tissue reperfusion, angiogenesis, and arteriogenesis over time. We have found that the beneficial effects of dipyridamole therapy are due to its ability to increase tissue nitric oxide bioavailability that corrects tissue redox imbalance. Importantly, we have also discovered that dipyridamole treatment invoking nitric oxide (NO) production significantly downregulates various innate immune response genes during chronic ischemic tissue injury. These findings demonstrate that dipyridamole-induced production of nitrite/NO significantly decreases inflammatory responses while increasing vascular growth in ischemic tissues.

journal_name

Ann N Y Acad Sci

authors

Pattillo CB,Fang K,Terracciano J,Kevil CG

doi

10.1111/j.1749-6632.2010.05737.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

83-8

eissn

0077-8923

issn

1749-6632

journal_volume

1207

pub_type

杂志文章,评审
  • Integrating human responses to climate change into conservation vulnerability assessments and adaptation planning.

    abstract::The impact of climate change on biodiversity is now evident, with the direct impacts of changing temperature and rainfall patterns and increases in the magnitude and frequency of extreme events on species distribution, populations, and overall ecosystem function being increasingly publicized. Changes in the climate sy...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12952

    authors: Maxwell SL,Venter O,Jones KR,Watson JE

    更新日期:2015-10-01 00:00:00

  • Latent autoimmune diabetes in adults.

    abstract::Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younge...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02953.x

    authors: Landin-Olsson M

    更新日期:2002-04-01 00:00:00

  • School-based programs for health-risk reduction.

    abstract::Based on implications from the pediatric studies of cardiovascular risk, it has become imperative that practical methods be developed to begin prevention of heart disease early in life. Schools provide an excellent setting for introducing comprehensive health education and promotion as a public health approach to the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb48208.x

    authors: Nicklas TA,Johnson CC,Webber LS,Berenson GS

    更新日期:1997-05-28 00:00:00

  • The etiology of anomalous sexual preferences in men.

    abstract::People discover rather than choose their sexual interests. The process of discovery typically begins before the onset of puberty and is associated with an increase in the secretion of sex hormones from the adrenal glands. However, the determinants of the direction of sexual interest, in the sense of preferences for th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07297.x

    authors: Quinsey VL

    更新日期:2003-06-01 00:00:00

  • Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.

    abstract::Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1299.034

    authors: Del Bello B,Valentini MA,Comporti M,Maellaro E

    更新日期:2003-12-01 00:00:00

  • Rituximab use in pediatric autoimmune diseases: four case reports.

    abstract::Rituximab (RTX) is currently used in many diseases, but its efficacy and safety in juvenile systemic lupus erythematosus (SLEj) is still unknown. In this chapter we present four case reports of children treated with RTX: three SLE and one immune thrombocytopenic purpura (ITP). Two of the three SLEj patients had class ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04804.x

    authors: Polido-Pereira J,Ferreira D,Rodrigues AM,Nascimento C,Costa P,Almeida M,da Silva JE,Simão C,Stone R,Ramos F,Neto A,da Costa JC,Melo-Gomes J,Gomes-Pedro J,Viana-Queiroz M,Canhão H,Fonseca JE

    更新日期:2009-09-01 00:00:00

  • Movements of vesicles on microtubules.

    abstract::Many cytoplasmic vesicles are observed to move along microtubules. Often, bidirectional movement of particles is observed on a single microtubule. We have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb27227.x

    authors: Sheetz MP,Vale R,Schnapp B,Schroer T,Reese T

    更新日期:1987-01-01 00:00:00

  • The discrimination of faces and their emotional content by chimpanzees (Pan troglodytes).

    abstract::The ability to recognize and discriminate conspecific faces and facial expressions has played a critical role in the evolution of social communication. Darwin was one of the first to speculate that human and nonhuman primate facial expressions share similar mechanisms for production and functions in expressing emotion...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1280.005

    authors: Parr LA

    更新日期:2003-12-01 00:00:00

  • Novel bioartificial liver support system: preclinical evaluation.

    abstract::Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a D-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb08516.x

    authors: Patzer JF 2nd,Mazariegos GV,Lopez R,Molmenti E,Gerber D,Riddervold F,Khanna A,Yin WY,Chen Y,Scott VL,Aggarwal S,Kramer DJ,Wagner RA,Zhu Y,Fulmer ML,Block GD,Amiot BP

    更新日期:1999-06-18 00:00:00

  • Food security, poverty, and human development in the United States.

    abstract::Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child-referenced items now make...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1425.001

    authors: Cook JT,Frank DA

    更新日期:2008-01-01 00:00:00

  • Developing a SERM: stringent preclinical selection criteria leading to an acceptable candidate (WAY-140424) for clinical evaluation.

    abstract::Estrogens are represented by a diverse group of compounds. Within this large family of molecules are tissue-selective estrogens that have been classified as selective estrogen receptor modulators (SERMs). These compounds are characterized by the fact that they exhibit both estrogen agonist and antagonist activity depe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb04039.x

    authors: Komm BS,Lyttle CR

    更新日期:2001-12-01 00:00:00

  • Different expansions of T lymphocyte subpopulations in the lung and corticosteroid-induced changes in patients with active pulmonary sarcoidosis.

    abstract::Pulmonary sarcoidosis is a disease characterized by increased numbers of T lymphocytes within the alveolar structures and the consequent spontaneous release of a variety of mediators relevant to the pathogenesis of this disorder. This phenomenon is associated with a different expansion of the T cell subpopulations pre...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb18488.x

    authors: Rossi GA,Sacco O,Cosulich E,Balbi B,Risso A,Ravazzoni C

    更新日期:1986-01-01 00:00:00

  • Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats.

    abstract::The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb51860.x

    authors: Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

    更新日期:1997-09-20 00:00:00

  • The role of prediction and anticipation on age-related effects on smooth pursuit eye movements.

    abstract::Externally guided sensory-motor processes deteriorate with increasing age. Internally guided, for example, predictive, behavior usually helps to overcome sensory-motor delays. We studied whether predictive components of visuomotor transformation decline with age. We investigated smooth pursuit eye movements (SPEM) of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06114.x

    authors: Sprenger A,Trillenberg P,Pohlmann J,Herold K,Lencer R,Helmchen C

    更新日期:2011-09-01 00:00:00

  • A new technology for mutation detection.

    abstract::A sensitive, accurate, and simple method, called shifted termination assay (STA), was developed for detection of genetic mutations. The STA technology can be used to detect genetic mutations in polymerase chain reaction (PCR)-amplified samples of tissue, and plasma and serum that include circulating DNA containing poi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1318.040

    authors: Shackelford W,Deng S,Murayama K,Wang J

    更新日期:2004-06-01 00:00:00

  • Comparative in vitro reactivities of leukocytes from sarcoids and normals to different Kveim preparations.

    abstract::Comparative studies of in vivo and in vitro reactivities to Kveim preparations have been carried out in 45 sarcoid and 30 normal subjects. Lymphocytes of 14 of 45 sarcoids and 4 of 30 normals proliferated significantly in response to at least 1 of the 4 Kveim suspensions used for in vitro studies. The prevalence of po...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47084.x

    authors: Zweiman B,Israel HL

    更新日期:1976-01-01 00:00:00

  • Biodiversity conservation through the lens of metacommunity ecology.

    abstract::Metacommunity ecology combines local (e.g., environmental filtering and biotic interactions) and regional (e.g., dispersal and heterogeneity) processes to understand patterns of species abundance, occurrence, composition, and diversity across scales of space and time. As such, it has a great potential to generalize an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14378

    authors: Chase JM,Jeliazkov A,Ladouceur E,Viana DS

    更新日期:2020-06-01 00:00:00

  • Functional roles of the alpha isoforms of the Na,K-ATPase.

    abstract::The Na,K-ATPase is composed of two subunits, alpha and beta, and each subunit consists of multiple isoforms. In the case of alpha, four isoforms, alpha1, alpha2, alpha3, and alpha4 are present in mammalian cells. The distribution of these isoforms is tissue- and developmental-specific, suggesting that they may play sp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07214.x

    authors: Lingrel J,Moseley A,Dostanic I,Cougnon M,He S,James P,Woo A,O'Connor K,Neumann J

    更新日期:2003-04-01 00:00:00

  • The effect of camptothecin on topoisomerase I catalysis.

    abstract::The existence of a covalent intermediate in topoisomerase I catalysis allows uncoupling of the cleavage and ligation half-reactions on partially single-stranded DNA substrates containing a highly preferred interaction site. Using this model DNA substrate system we have demonstrated that the cleavage reaction requires ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb26376.x

    authors: Christiansen K,Westergaard O

    更新日期:1996-12-13 00:00:00

  • Osteopontin expression in cardiovascular diseases.

    abstract::Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb44624.x

    authors: Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

    更新日期:1995-04-21 00:00:00

  • Molecular immunogenetics in susceptibility to bovine dermatophilosis: a candidate gene approach and a concrete field application.

    abstract::To identify molecular genetic markers of resistance or susceptibility to dermatophilosis in cattle, we used a functional candidate gene approach to analyze the DNA polymorphisms of targeted genes encoding molecules implicated in known mechanisms of both nonspecific and specific immune responses existing in the pathoge...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04357.x

    authors: Maillard JC,Chantal I,Berthier D,Thevenon S,Sidibe I,Razafindraibe H

    更新日期:2002-10-01 00:00:00

  • Pressure study on symmetric and asymmetric phospholipid bilayers: effect of vesicle size on Prodan fluorescence.

    abstract::The bilayer phase behavior of symmetric and asymmetric phosphatidylcholines (PCs), 1,2-diheptadecanoyl-PC (C17PC), 1-palmitoyl-2-stearoyl-PC (PSPC), and 1-stearoyl-2-palmitoyl-PC (SPPC), with different vesicle sizes were investigated by a high-pressure fluorescence method using the polarity-sensitive fluorescent probe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05202.x

    authors: Goto M,Kusube M,Nishimoto M,Tamai N,Matsuki H,Kaneshina S

    更新日期:2010-02-01 00:00:00

  • Historical review of the significance of the cerebellum and the role of Purkinje cells in motor learning.

    abstract::Classic studies of the cerebellum before the middle of the twentieth century established the structural entity of the cerebellum and characterized its function as enabling animals and humans to carry out smooth and accurate movements, even at a high speed and without visual feedback. In the 1960s, neuronal circuit str...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1749-6632.2002.tb07574.x

    authors: Ito M

    更新日期:2002-12-01 00:00:00

  • New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

    abstract::The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/nyas.12580

    authors: Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

    更新日期:2014-12-01 00:00:00

  • Data requirements of reverse-engineering algorithms.

    abstract::Data Sets used in reverse engineering of biochemical networks contain usually relatively few high-dimensional data points, which makes the problem in general vastly underdetermined. It is therefore important to estimate the probability that a given algorithm will return a model of acceptable quality when run on a data...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1407.008

    authors: Just W

    更新日期:2007-12-01 00:00:00

  • Type of dietary fat and insulin resistance.

    abstract::Animal studies have already shown the possibility to modulate insulin action by changing not only the amount of total fat, but also the type of fat. In these studies, saturated fat significantly increased insulin resistance, long- and short-chain omega(3) fatty acids significantly improved it, whereas the effects of m...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04288.x

    authors: Rivellese AA,De Natale C,Lilli S

    更新日期:2002-06-01 00:00:00

  • Evolutionary genetics of the melanocortin-1 receptor in vertebrates.

    abstract::The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb03194.x

    authors: Mundy NI,Kelly J,Theron E,Hawkins K

    更新日期:2003-06-01 00:00:00

  • Cardiomyopathy and encephalopathy in AIDS.

    abstract::HIV encephalopathy has been in the past years the most typical CNS disorder in patients with AIDS. Histologic abnormalities consist in astrocytosis, myelin pallor, infiltration by infected macrophages, resident microglia and multinucleated giant cells, generally in absence of direct infection of neurons. Mononuclear p...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03907.x

    authors: Antinori A,Giancola ML,Alba L,Soldani F,Grisetti S

    更新日期:2001-11-01 00:00:00

  • Tissue-specific estrogen biosynthesis and metabolism.

    abstract::While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb04002.x

    authors: Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

    更新日期:2001-12-01 00:00:00

  • Epigenetics and the environment.

    abstract::DNA methylation and histone modification promote changes in chromatin structure that may affect gene expression in a heritable manner without directly altering the genome. As such, these phenomena are considered to be epigenetic in nature and are believed to contribute to the normal processes of human development but ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb05970.x

    authors: Sutherland JE,Costa M

    更新日期:2003-03-01 00:00:00