Genetic engineering and therapy for inherited and acquired cardiomyopathies.

abstract：:Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...

journal_title：Annals of the New York Academy of Sciences

authors： Graybill JR,Stevens DA,Galgiani JN,Sugar AM,Craven PC,Gregg C,Huppert M,Cloud G,Dismukes WE

更新日期：1988-01-01 00:00:00

abstract：:Previous studies showed that exposure of experimental animals to immobilization stress increases colonic motility and that these effects are mediated by release of corticotropin-releasing factor (CRF), Studies from our laboratory showed that 30-min immobilization stress of rats caused several not previously described ...

journal_title：Annals of the New York Academy of Sciences

authors： Pothoulakis C,Castagliuolo I,Leeman SE

更新日期：1998-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:The plasma levels and the glycosylation of acute-phase proteins (APP) are subject to marked changes during acute and chronic inflammation. The pathophysiological variations in different glycoforms of APP in serum most likely result from changes in the glycosylation process during their biosynthesis in the parenchymal ...

journal_title：Annals of the New York Academy of Sciences

authors： Van Dijk W,Mackiewicz A

更新日期：1995-07-21 00:00:00

abstract：:Will the development of safe, accurate prenatal diagnosis for Cooley's anemia result in a reduction in the unwanted birth of children with Cooley's anemia in the United States? Since detection of couples at risk only through the birth of an affected child will lead to a minimal reduction in the incidence of the diseas...

journal_title：Annals of the New York Academy of Sciences

authors： Rowley PT,Loader S,Walden ME

更新日期：1985-01-01 00:00:00

abstract：:The aim of this study was to examine changes in muscle cell injury and antioxidant capacity of weightlifters following a 1-week intensive resistance-training regimen. Thirty-six female subjects participated in this study, and their ages ranged from 18 to 25 years. The sample group included 19 elite weightlifters with ...

journal_title：Annals of the New York Academy of Sciences

authors： Liu JF,Chang WY,Chan KH,Tsai WY,Lin CL,Hsu MC

更新日期：2005-05-01 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:During viewing of a near target, the gain of the visually modulated vestibulo-ocular reflex (vVOR) exceeds 1.0. We investigated whether retinal image slip contributes to this gain increase by measuring responses during strobe illumination. Subjects showed greater gain values during normal versus strobe illumination of...

journal_title：Annals of the New York Academy of Sciences

authors： Han YH,Kumar AN,Somers JT,Reschke MF,Leigh RJ

更新日期：2005-04-01 00:00:00

abstract：:In this study, we measured the lymphocyte levels of proteins involved in apoptosis regulation, such as Bcl-2, the peripheral benzodiazepine receptor (PBR), caspase-3, and Cu/Zn superoxide dismutase (Cu/Zn SOD), in patients with Parkinson's disease (PD), either untreated or under therapy with dopaminergic agents (l-Dop...

journal_title：Annals of the New York Academy of Sciences

authors： Blandini F,Mangiagalli A,Cosentino M,Marino F,Samuele A,Rasini E,Fancellu R,Martignoni E,Riboldazzi G,Calandrella D,Frigo GM,Nappi G

更新日期：2003-12-01 00:00:00

abstract：:It is thought that human natural killer (NK) lymphocytes should not damage self-tissues due to the inhibiting signal initiated by the engagement of one or another inhibitory receptor superfamily (IRS) members with self-human histocompatibility antigen (HLA)-I. During viral infection, the low expression of self-HLA-I o...

journal_title：Annals of the New York Academy of Sciences

authors： Poggi A,Prevosto C,Zancolli M,Canevali P,Musso A,Zocchi MR

更新日期：2007-08-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread ...

journal_title：Annals of the New York Academy of Sciences

authors： Granger DA,Kivlighan KT,el-Sheikh M,Gordis EB,Stroud LR

更新日期：2007-03-01 00:00:00

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...

journal_title：Annals of the New York Academy of Sciences

authors： Wainfan E,Maschio FA

更新日期：1975-08-08 00:00:00

abstract：:In plants, the photons of light are absorbed at the level of the photosystems in the chloroplasts. The functioning of the photosynthetic electron transfer chain linked to this process is required to generate NADPH and ATP. In addition, the light signal promotes a regulatory cascade, situated in the stroma, that involv...

journal_title：Annals of the New York Academy of Sciences

authors： Jacquot JP,Rouhier N,Gelhaye E

更新日期：2002-11-01 00:00:00

abstract：:Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

journal_title：Annals of the New York Academy of Sciences

authors： Lawn P

更新日期：2011-02-01 00:00:00

abstract：:Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

journal_title：Annals of the New York Academy of Sciences

authors： Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:Photochemical smog is caused by a free-radical chain mechanism which converts NO to NO2. The NO2 further reacts to produce ozone, nitric acid, and peracylnitrates. This chain mechanism can be inhibited by suitable free-radical scavengers. The chemistry and toxicology of one such free-radical scavenger, diethylhydroxyl...

journal_title：Annals of the New York Academy of Sciences

authors： Heicklen J

更新日期：1987-01-01 00:00:00

abstract：:We have established that a preferential export of pyruvate-generated citrate occurs from cholesterol-rich tumor mitochondria, with both isolated mitochondrial systems as well as with viable tumor tissue slices (i.e., with whole tumors cells). Furthermore, we have demonstrated that the more rapid citrate efflux kinetic...

journal_title：Annals of the New York Academy of Sciences

authors： Coleman PS

更新日期：1986-01-01 00:00:00

abstract：:Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s,...

journal_title：Annals of the New York Academy of Sciences

authors： Harbuz MS,Chover-Gonzalez AJ,Jessop DS

更新日期：2003-05-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7...

journal_title：Annals of the New York Academy of Sciences

authors： Scott DJ,Layfield S,Riesewijk A,Morita H,Tregear GW,Bathgate RA

更新日期：2005-05-01 00:00:00

abstract：:The presence of R. prowazekii in lice using R. prowazekii-specific qPCR cassettes showed the changes of the rickettsial burden in the lice post-infection. ...

journal_title：Annals of the New York Academy of Sciences

authors： Rozmajzl PJ,Houhamdi L,Jiang J,Raoult D,Richards AL

更新日期：2006-10-01 00:00:00

abstract：:The gain of the angular vestibulo-ocular reflex (aVOR) was determined in monkeys by rotation about a spatial vertical axis while upright or statically tilted forward and backward. Horizontal, vertical, and roll gains were determined at each head orientation and plotted as a function of head tilt. Before canal plugging...

journal_title：Annals of the New York Academy of Sciences

authors： Yakushin SB,Dai M,Raphan T,Suzuki J,Arai Y,Cohen B

更新日期：2001-10-01 00:00:00

abstract：:Learning to play a musical instrument requires complex multimodal skills involving simultaneous perception of several sensory modalities: auditory, visual, and somatosensory as well as the motor system. Musical training thus provides an adequate neuroscientific model to study multimodal integration and plasticity in m...

journal_title：Annals of the New York Academy of Sciences

authors： Pantev C,Lappe C,Herholz SC,Trainor L

更新日期：2009-07-01 00:00:00

abstract：:Obstructive sleep apnea is often regarded as a structural disorder causing narrowing of the airway. This article reviews the neurological aspects of obstructive sleep apnea, including the upper airway reflex, cortical arousal thresholds, and motor function as they pertain to the pathophysiology of disease. We also dis...

journal_title：Annals of the New York Academy of Sciences

authors： Broderick M,Guilleminault C

更新日期：2008-10-01 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Sex differences in social behavior are center stage in recent formulations of evolutionary psychology. Evolutionary psychology, with its emphasis on the long-term consequences of early adaptations, offers itself as an alternative meta-theory to mainstream social psychology, which emphasizes the importance of social st...

journal_title：Annals of the New York Academy of Sciences

authors： Rabinowitz VC,Valian V

更新日期：2000-04-01 00:00:00

abstract：:Gonadal hormones, particularly androgens, direct certain aspects of brain development and exert permanent influences on sex-typical behavior in nonhuman mammals. Androgens also influence human behavioral development, with the most convincing evidence coming from studies of sex-typical play. Girls exposed to unusually ...

journal_title：Annals of the New York Academy of Sciences

authors： Hines M

更新日期：2003-12-01 00:00:00

abstract：:Regulation of carbohydrate and fat utilization by skeletal muscle at rest and during exercise has been the subject of investigation since the early 1960s when Randle et al. proposed the so-called glucose-fatty acid cycle to explain the reciprocal relationship between carbohydrate and fat metabolism. The suggested mech...

journal_title：Annals of the New York Academy of Sciences

authors： Jeukendrup AE

更新日期：2002-06-01 00:00:00