Gastrointestinal pharmacology: practical tips for the esophagologist.

abstract：:Although much is known about the pleiotropic effects mediated by relaxin, the exact signaling pathways involved remain relatively elusive. This study examines LGR7 and LGR8 signaling using reporter gene technology. The greatest response was observed at the CRE reporter (indicates activation of cAMP-PKA and p38/JNK pat...

journal_title：Annals of the New York Academy of Sciences

authors： Halls ML,Bathgate RA,Roche PJ,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through th...

journal_title：Annals of the New York Academy of Sciences

authors： Angermüller S,Schümann J,Fahimi HD,Tiegs G

更新日期：1999-01-01 00:00:00

abstract：:The cell nucleus is a prominent target of autoantibodies in systemic autoimmune disorders. Approximately 2% of the population in Europe and North America suffers from systemic rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and scleroderma. The molecular mechanisms of systemic aut...

journal_title：Annals of the New York Academy of Sciences

authors： Chen M,von Mikecz A

更新日期：2005-06-01 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

journal_title：Annals of the New York Academy of Sciences

authors： Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

更新日期：2014-12-01 00:00:00

abstract：:Human speech perception seems to involve the ability to recognize groupings of speech sounds rather than component phonemes, and to distinguish between permuted orders of items within sequences as holistic entities. Humans can use this Holistic Pattern Recognition (HPR) not only with speech and music, but also with se...

journal_title：Annals of the New York Academy of Sciences

authors： Warren RM

更新日期：1976-01-01 00:00:00

abstract：:In a retrospective studies of spontaneous abortion, bias can arise if the investigator restricts attention to the outcome of the most recent pregnancy. Bias happens because couples tend to replace spontaneous abortions with other pregnancies until they achieve a live birth, after which they may avoid conception for a ...

journal_title：Annals of the New York Academy of Sciences

authors： Weinberg CR,Baird DD,Wilcox AJ

更新日期：1994-02-18 00:00:00

abstract：:This paper describes the flight experiment, supporting ground science, and the design rationale for a project on spaceflight holography investigation in a virtual apparatus (SHIVA). SHIVA is a fundamental study of particle dynamics in fluids in microgravity. Gravitation effects and steady Stokes drag often dominate th...

journal_title：Annals of the New York Academy of Sciences

authors： Trolinger JD,L'Esperance D,Rangel RH,Coimbra CF,Witherow WK

更新日期：2004-11-01 00:00:00

abstract：:Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main area...

journal_title：Annals of the New York Academy of Sciences

authors： Caplat P,Coutts S,Buckley YM

更新日期：2012-02-01 00:00:00

abstract：:In two series of antiarrhythmic drugs tested, as the octanol/water partition coefficient increases so do the following: elimination from the body by biotransformation, first-pass biotransformation in the liver and gastrointestinal tract after oral administration, protein binding to some extent, and penetration into br...

journal_title：Annals of the New York Academy of Sciences

authors： Drayer DE

更新日期：1984-01-01 00:00:00

abstract：:TGF beta is a cytokine which is involved with the regulation of different aspects of host defense responses to injury. Overexpression of TGF beta can lead to the conversion of its protective functions to pathogenetic manifestations. TGF beta is a potent factor in promoting anabolic aspects in connective tissue metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Lotz M,Seth P

更新日期：1993-06-23 00:00:00

abstract：:The avoidance of autoimmunity requires mechanisms to actively silence or tolerize self reactive T cells in the periphery. During infection, dendritic cells are not only capturing microbial antigens, but also are processing self antigens from dying cells as well as innocuous environmental proteins. Since the dendritic ...

journal_title：Annals of the New York Academy of Sciences

authors： Steinman RM,Hawiger D,Liu K,Bonifaz L,Bonnyay D,Mahnke K,Iyoda T,Ravetch J,Dhodapkar M,Inaba K,Nussenzweig M

更新日期：2003-04-01 00:00:00

abstract：:Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signa...

journal_title：Annals of the New York Academy of Sciences

authors： Lee AM,Messing RO

更新日期：2008-10-01 00:00:00

abstract：:CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is an evolutionarily conserved novel gene. Recently, we have demonstrated that CISD2 is involved in mammalian lifespan control; this work also establishes WFS2 as a mitochondria-mediated disorder and effectively links CISD2 gene function, mitochondrial integrity...

journal_title：Annals of the New York Academy of Sciences

authors： Chen YF,Wu CY,Kirby R,Kao CH,Tsai TF

更新日期：2010-07-01 00:00:00

abstract：:Especially since the (re-)discovery of T cell subpopulations with specialized regulatory activities, mechanisms of anti-inflammatory T cell regulation are studied very actively and are expected to lead to the development of novel immunotherapeutic approaches, especially in chronic inflammatory diseases. Heat shock pro...

journal_title：Annals of the New York Academy of Sciences

authors： Van Eden W,Wick G,Albani S,Cohen I

更新日期：2007-10-01 00:00:00

abstract：:The activator protein-1 (AP-1) binding activities in the three brain regions (striatum, nucleus accumbens, cingulate cortex) increased after a single methamphetamine (METH, 4 mg/kg) injection and reached maximum levels after 180 min. Pretreatment with SCH 23390 (0.5 mg/kg), a selective dopamine D1 receptor antagonist,...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama K,Ishihara T,Kashihara K

更新日期：1996-10-31 00:00:00

abstract：:There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize differ...

journal_title：Annals of the New York Academy of Sciences

authors： Biesalski HK

更新日期：2016-05-01 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:The New York Stem Cell Foundation's "Fifth Annual Translational Stem Cell Research Conference" convened on October 12-13, 2010 at the Rockefeller University in New York City. The conference attracted over 400 scientists, patient advocates, and stem cell research supporters from 16 countries. In addition to poster and ...

journal_title：Annals of the New York Academy of Sciences

authors： Marshall C,Wang GK,Cimetta E,Talchai C,Egli D,Shim JW,Martin I,Ahmad F,Sproul A,Chen T,Fossati V,McKeon D,Smith K,Solomon SL

更新日期：2011-05-01 00:00:00

abstract：:This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

journal_title：Annals of the New York Academy of Sciences

authors： Neau L,Pruvost J,Rodriguez O,Loc TP

更新日期：2002-10-01 00:00:00

abstract：:Recent cross-cultural studies of child development reveal that child rearing, while strikingly culturally variable, is everywhere designed to make the child's experience of important lessons constant, to link those lessons to emotional arousal, and to connect them to evaluations of the child's goodness and badness. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn N

更新日期：2003-10-01 00:00:00

abstract：:The constitution of platelet-fibrin(ogen) contacts, the separation of the platelets initially aggregated, and the rearrangement of the platelet cytoskeleton during clot formation (0.5 to 60 minutes after thrombin stimulation) were investigated using ultrastructural and immunocytochemical techniques. After aggregation,...

journal_title：Annals of the New York Academy of Sciences

authors： Morgenstern E,Daub M,Dierichs R

更新日期：2001-01-01 00:00:00

abstract：:Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metaboli...

journal_title：Annals of the New York Academy of Sciences

authors： Komatsu Y,Aoyama K,Yoneda M,Ito S,Sano Y,Kawai Y,Cui X,Yamada Y,Furukawa N,Ikeda K,Nagata K

更新日期：2020-12-19 00:00:00

abstract：:Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (tetanus toxoid), that absolute levels of proliferation, minimally detecta...

journal_title：Annals of the New York Academy of Sciences

authors： Narendran P,Elsegood K,Leech NJ,Dayan CM

更新日期：2002-04-01 00:00:00

abstract：:1. One can accurately predict the contribution of each inhibitor to the total inactivation of an enzyme in plasma once its pseudo-first-order reaction rate constant and concentration are known. 2. Because the mechanism of augmentation of the inactivation rate of an enzyme by ATIII occurs via formation of an ATIII-hepa...

journal_title：Annals of the New York Academy of Sciences

authors： Colman RW,Scott CF,Pixley RA,de la Cadena RA

更新日期：1989-01-01 00:00:00

abstract：:Ischemic preconditioning (PC) is a polygenic defensive cellular adaptive phenomenon whereby brief ischemic stimuli render the heart resistant to subsequent similar stress. The late phase of ischemic PC lasts for three to four days, protects against both myocardial stunning and infarction, and thus has considerable cli...

journal_title：Annals of the New York Academy of Sciences

authors： Dawn B,Bolli R

更新日期：2002-05-01 00:00:00

abstract：:Athletic women are at risk for developing ovulatory dysfunction, which presents variably as menstrual irregularity or absence. Initially characterized as an isolated disruption of hypothalamic gonadotropin-releasing hormone (GnRH) release, athletic amenorrhea, a form of hypogonadotropic hypogonadism, is invariably acc...

journal_title：Annals of the New York Academy of Sciences

authors： Pauli SA,Berga SL

更新日期：2010-09-01 00:00:00

abstract：:Researchers in Utrecht, the Netherlands have studied the effects of different factors, such as oral contraceptives (OCs), on sex hormone binding globulin (SHBG) levels in blood. The SHBG levels in women who continuously used OCs consisting only of .05 mg of ethinyl estradiol (EE2) rose as high as 260% + or - 25% of t...

journal_title：Annals of the New York Academy of Sciences

authors： Thijssen JH

更新日期：1988-01-01 00:00:00