当前位置： SCI文献检索 > Annals of the New York Academy of Sciences期刊下所有文献 > Effect of acute and chronic administration of methamphetamine on activator protein-1 binding activities in the rat brain regions.

Effect of acute and chronic administration of methamphetamine on activator protein-1 binding activities in the rat brain regions.

Abstract：

:The activator protein-1 (AP-1) binding activities in the three brain regions (striatum, nucleus accumbens, cingulate cortex) increased after a single methamphetamine (METH, 4 mg/kg) injection and reached maximum levels after 180 min. Pretreatment with SCH 23390 (0.5 mg/kg), a selective dopamine D1 receptor antagonist, significantly inhibited the enhanced AP-1 binding activities induced by acute METH (4 mg/kg) administration. In chronic experiments, rats were pretreated with METH (4 mg/kg) or saline for 14 days. The AP-1 binding activities after a 1-week abstinence from chronic administration of MAP increased significantly in all the brain regions compared with those of the saline-treated controls, whereas after a 4-week abstinence, the AP-1 binding activity decreased significantly in the cingulate cortex, but not striatum or nucleus accumbens, compared with the saline-treated control group. A METH challenge after a 4-week abstinence period induced significantly more intense stereotypy, but lower AP-1 binding activities in all the brain regions of rats treated with repeated METH than repeated saline injections. The super-shift assay revealed that after a 1- or 4-week abstinence, there was no significant difference between the Fos-related antigens (Fras) contents of the saline- and METH-treated groups in any brain region examined, and that the Jun family protein levels of the METH-treated group increased significantly in the striatum and nucleus accumbens after a 1-, but not 4-, week abstinence. These results suggest that chronic METH administration leads to delayed decay of the induced AP-1 binding activities and Jun component levels after abstinence for up to 1 week, but results in no change in or decreases these activities and attenuates METH challenge-induced AP-1 binding activities after abstinence for 4 weeks.

journal_name

Ann N Y Acad Sci

journal_title

Annals of the New York Academy of Sciences

authors

Akiyama K,Ishihara T,Kashihara K

doi

10.1111/j.1749-6632.1996.tb17428.x

subject

Has Abstract

pub_date

1996-10-31 00:00:00

pages

13-28

eissn

0077-8923

issn

1749-6632

journal_volume

801

pub_type

杂志文章

在线工具

Effect of acute and chronic administration of methamphetamine on activator protein-1 binding activities in the rat brain regions.