The NMDA receptor hypofunction model of psychosis.

abstract：:To identify a selective inhibitor of mammalian agmatinase, screening was performed on four analogues of agmatine with modifications directly to the guanidine group, six analogues with modifications to the carbon-amine chain, and one analogue with modifications at both ends of the molecule. Control compounds were amino...

journal_title：Annals of the New York Academy of Sciences

authors： Huang MJ,Regunathan S,Botta M,Lee K,McClendon E,Yi GB,Pedersen ML,Berkowitz DB,Wang G,Travagli M,Piletz JE

更新日期：2003-12-01 00:00:00

abstract：:Increase in the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. In neuroblastoma, amplification of the gene MYCN has been associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value in identifying pat...

journal_title：Annals of the New York Academy of Sciences

authors： Schwab M

更新日期：2002-06-01 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the world's population. The number of diabetic patients will reach 300 million in 2025 (International Diabetes Federation, 2001). More than 97% of these patients will have type II diabetes. The projected increase in the number of di...

journal_title：Annals of the New York Academy of Sciences

authors： Adeghate E,Schattner P,Dunn E

更新日期：2006-11-01 00:00:00

abstract：:To date, the precise etiology of inflammatory bowel disease (IBD) remains largely unknown; however, it is well accepted that IBD results from a dysregulated mucosal immune response to environmental factors in genetically susceptible hosts. The primary defect, in at least a subpopulation of IBD patients, may be due to ...

journal_title：Annals of the New York Academy of Sciences

authors： Reuter BK,Pizarro TT

更新日期：2009-05-01 00:00:00

abstract：:Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

journal_title：Annals of the New York Academy of Sciences

authors： Bell PJ

更新日期：2009-10-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and peptide histidine-isoleucine (PHI) are members of a superfamily of structurally related peptides widely distributed in the body and displaying pleiotropic biological activities. All these peptides are known to act via ...

journal_title：Annals of the New York Academy of Sciences

authors： Dejda A,Jozwiak-Bebenista M,Nowak JZ

更新日期：2006-07-01 00:00:00

abstract：:Glucose conversion by brain synaptosomes can be regarded as a special case of intrinsic kinetic properties of the enzyme substrate system. Temperature modulation of apparent K(m) for this process can be described with our kinetic model. Using experimental data and the kinetic model, the minimal K(m) value for glucose ...

journal_title：Annals of the New York Academy of Sciences

authors： Marjanović M,Zivadinović D,Dzakula Z,Andjus RK

更新日期：2005-06-01 00:00:00

abstract：:Landesberg and Sideman's four state model of the cardiac cross-bridge (XB) hypothesizes a feedback of force development to Ca(2+) binding by troponin C (TnC). We have further modeled this behavior and observed that the force (F)-Ca(2+) relationship as well as the F-sarcomere length (SL) relationship and the time cours...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Wakayama Y,Miura M,Stuyvers BD,Boyden PA,Landesberg A

更新日期：2005-06-01 00:00:00

abstract：:Three distinct pathological conditions, related to different means by which dense intralabyrinthine particles interfere with the function of a semicircular canal and cause nystagmus and vertigo, are amenable to treatment with repositioning maneuvers. Known as benign paroxysmal positional vertigo and variants, these co...

journal_title：Annals of the New York Academy of Sciences

authors： Epley JM

更新日期：2001-10-01 00:00:00

abstract：:The same retinal image motion can be produced by a variety of combinations of eye and target motion. In natural conditions, extraretinal information disambiguates retinal information for motion perception. By controlling the timing of visual motion with respect to saccades, it was possible to appraise the roles for mo...

journal_title：Annals of the New York Academy of Sciences

authors： Lee C,Lee J

更新日期：2005-04-01 00:00:00

abstract：:The presence in the serum of specific autoantibodies, such as antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), and antiextractable nuclear antigens (anti-ENA), is one of the diagnostic criteria for autoimmune rheumatic disease, and the requests for these tests in the last few years have grown remar...

journal_title：Annals of the New York Academy of Sciences

authors： Bonaguri C,Melegari A,Dall'Aglio P,Ballabio A,Terenziani P,Russo A,Battistelli L,Aloe R,Camisa R,Campaniello G,Sartori E,Monica C

更新日期：2009-09-01 00:00:00

abstract：:Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca(2+)/calmodulin signaling in osteoclast developmen...

journal_title：Annals of the New York Academy of Sciences

authors： Williams JP,Micoli K,McDonald JM

更新日期：2010-03-01 00:00:00

abstract：:Osteoblast-specific gene transcription requires interaction between bone cell-specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain-leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibite...

journal_title：Annals of the New York Academy of Sciences

authors： St-Arnaud R,Hekmatnejad B

更新日期：2011-11-01 00:00:00

abstract：:Megadose haploidentical transplants, mismatched at three HLA loci, engraft rapidly and durably without induction of graft-versus-host disease (GVHD). In vitro studies suggest that veto cells, contained in the population of hematopoietic progenitors, facilitate this favorable outcome. Cytotoxic T cells, not reactive ag...

journal_title：Annals of the New York Academy of Sciences

authors： Reisner Y

更新日期：2001-06-01 00:00:00

abstract：:The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV-1), kills uninfected cells expressing CD4 and/or the chemokine receptor CXCR4 or CCR5, via at least three independent mechanisms. First, the soluble Env product gp120 can induce the apoptotic cell death of lymphocytes, neurons, a...

journal_title：Annals of the New York Academy of Sciences

authors： Castedo M,Perfettini JL,Andreau K,Roumier T,Piacentini M,Kroemer G

更新日期：2003-12-01 00:00:00

abstract：:Traditionally, studies measuring behavioral activity have used male adult animals and grid crossings (GCs) as a representative measure of activity in lieu of total distance moved (TDM). However, using GCs as the dependent measure may not be effective for comparing the activity of animals during development, as they va...

journal_title：Annals of the New York Academy of Sciences

authors： Vila JL,Philpot RM,Kirstein CL

更新日期：2004-06-01 00:00:00

abstract：:The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transacti...

journal_title：Annals of the New York Academy of Sciences

authors： Soussi T

更新日期：2000-06-01 00:00:00

abstract：:Questions about music's evolution and functions have long excited interest among scholars. More recent theoretical accounts have stressed the importance of music's social origins and functions. Autism and Williams syndrome, neurodevelopmental disorders supposedly characterized by contrasting social and musical phenoty...

journal_title：Annals of the New York Academy of Sciences

authors： Heaton P,Allen R

更新日期：2009-07-01 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

journal_title：Annals of the New York Academy of Sciences

authors： Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：:Asbestos-induced pleural fibrosis is the most common radiographic abnormality among asbestos-exposed persons. Circumscribed pleural plaques and diffuse pleural thickening account for more than 90% of the asbestos-induced chest wall abnormalities, and their prevalence is expected to increase for the next 15 to 20 years...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz DA

更新日期：1991-12-31 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:This article reviews research on the Finnish model of peer-group mentoring (PGM). The theoretical foundation of the model is based on the constructivist theory of learning, the concept of autonomy in teaching profession, peer learning, and narrative identity work. The model has been disseminated nationwide in the educ...

journal_title：Annals of the New York Academy of Sciences

authors： Tynjälä P,Pennanen M,Markkanen I,Heikkinen HLT

更新日期：2021-01-01 00:00:00

abstract：:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...

journal_title：Annals of the New York Academy of Sciences

authors： Baraniuk JN,Merck SJ

更新日期：2009-07-01 00:00:00

abstract：:Calcium ions are essential to proper neurotransmission. Impairment in cytosolic Ca(2+) concentration and Ca(2+) signaling disturbs neuronal activity, leading to pathological consequences. In cells, a high-affinity plasma membrane calcium pump (PMCA) keeps free Ca(2+) in the nanomolar range. Among four genes encoding t...

journal_title：Annals of the New York Academy of Sciences

authors： Zylinska L,Kowalska I,Kozaczuk A

更新日期：2008-12-01 00:00:00

abstract：:The serologic and molecular characterization of four monoclonal antibodies to human gastric cancer cells and to CEA were described and the immunohistologic patterns of reactions with freshly obtained gastrointestinal tissues were examined. Monoclonal antibody YK004, which was secreted by the hybridoma constructed with...

journal_title：Annals of the New York Academy of Sciences

authors： Yachi A,Imai K,Moriya Y,Fujita H,Tanda M,Nishi S,Kawaharada M

更新日期：1983-01-01 00:00:00

abstract：:In this note epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, ...

journal_title：Annals of the New York Academy of Sciences

authors： Emmeche C

更新日期：2000-01-01 00:00:00

abstract：:Thymic tolerance depends on induction of apoptosis (programmed cell death) in immature thymocytes by antigen/MHC complexes on dendritic cells (and possibly other bone marrow-derived APCs). Interactions with antigen/MHC complexes on thymic epithelial cells promote maturation of double-positive thymocytes to single-posi...

journal_title：Annals of the New York Academy of Sciences

authors： Owen JJ,Jenkinson EJ

更新日期：1992-11-21 00:00:00

abstract：:The emphasis on the effects of early olfactory restriction has been on the deleterious nature of the consequences of this abnormal early experience. While these effects are certainly present and dramatic, it is also the case that the olfactory system is left fairly intact by this experimental manipulation. If one asks...

journal_title：Annals of the New York Academy of Sciences

authors： Leon M

更新日期：1998-11-30 00:00:00

abstract：:These initial studies show that deregulated expression of ALG7 affects diverse cellular functions crucial to development, including proliferation, differentiation, and morphogenesis. Furthermore, the data suggest multiple genetic targets for ALG7 and provide the basis for future dissection of these developmentally rel...

journal_title：Annals of the New York Academy of Sciences

authors： Lennon K,Bird A,Kukuruzinska MA

更新日期：1998-04-15 00:00:00