Amplified MYCN in human neuroblastoma: paradigm for the translation of molecular genetics to clinical oncology.

Abstract:

:Increase in the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. In neuroblastoma, amplification of the gene MYCN has been associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value in identifying patients with neuroblastoma who require specific therapeutic regimens and those who do not benefit from chemotherapy.

journal_name

Ann N Y Acad Sci

authors

Schwab M

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

63-73

eissn

0077-8923

issn

1749-6632

journal_volume

963

pub_type

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