What effect does controlling platelets have on atherosclerosis?

Abstract:

:Platelets play important roles for hemostasis with activated platelets adhering to the injured vessel wall to initiate platelet aggregation. At the same time, our study revealed the cytotoxic effect on endothelial cells characterized by an increase of intracellular Ca++ and a decrease of EDRF production, which may cause plasmal infiltration including blood cells and lipids. Our clinical survey using a small dose of aspirin as an antiplatelet therapy clearly demonstrated its suppressive effect on platelet aggregation and its favorable effect on fibrinolysis. These data suggest that the therapeutic effect of aspirin in vascular disease could be applied to the prevention of thrombus formation and the protection of endothelial cells from the cytotoxic effect of activated platelets.

journal_name

Ann N Y Acad Sci

authors

Numano F,Kishi Y,Ashikaga T,Hata A,Makita T,Watanabe R

doi

10.1111/j.1749-6632.1994.tb17334.x

subject

Has Abstract

pub_date

1995-01-17 00:00:00

pages

383-92; discussion 392-3

eissn

0077-8923

issn

1749-6632

journal_volume

748

pub_type

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