Abstract:
:Platelets play important roles for hemostasis with activated platelets adhering to the injured vessel wall to initiate platelet aggregation. At the same time, our study revealed the cytotoxic effect on endothelial cells characterized by an increase of intracellular Ca++ and a decrease of EDRF production, which may cause plasmal infiltration including blood cells and lipids. Our clinical survey using a small dose of aspirin as an antiplatelet therapy clearly demonstrated its suppressive effect on platelet aggregation and its favorable effect on fibrinolysis. These data suggest that the therapeutic effect of aspirin in vascular disease could be applied to the prevention of thrombus formation and the protection of endothelial cells from the cytotoxic effect of activated platelets.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Numano F,Kishi Y,Ashikaga T,Hata A,Makita T,Watanabe Rdoi
10.1111/j.1749-6632.1994.tb17334.xsubject
Has Abstractpub_date
1995-01-17 00:00:00pages
383-92; discussion 392-3eissn
0077-8923issn
1749-6632journal_volume
748pub_type
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