Mechanosensitive-mediated interaction, integration, and cardiac control.

Abstract:

:This review covers aspects of the cardiac mechanotransduction field at different levels, and advocates the possibility that mechanoelectro-chemical transduction forms part of a network of mechanically linked integration in heart-mechanically mediated integration (MMI). It assembles evidence and observations in the literature to promote this hypothesis. Mechanical components can provide the bond between interactions at molecular, cellular, and macro levels to enable the integration. Stretch-activated channels (SACs) exist in the heart, but stresses and strains can affect other membrane channels or receptors. A cellular mechanical change can thus promote several ionic or downstream changes. Cell signal cascades have been implicated and can affect membrane electrophysiology. MMI could shape intracellular and downstream signals using the cytoskeleton and intracellular Ca(2+). MMI also spans other regulatory systems and processes such as the autonomic nervous system (ANS) and operates throughout the whole heart as an integrative system. Finally, supporting the hypothesis, if elements of the normal integration become deranged it contributes to cardiovascular disease and, potentially, lethal arrhythmia.

journal_name

Ann N Y Acad Sci

authors

Lab MJ

doi

10.1196/annals.1380.022

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

282-300

eissn

0077-8923

issn

1749-6632

pii

1080/1/282

journal_volume

1080

pub_type

杂志文章,评审
  • Critically important antibiotics: criteria and approaches for measuring and reducing their use in food animal agriculture.

    abstract::Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all ap...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14058

    authors: Scott HM,Acuff G,Bergeron G,Bourassa MW,Gill J,Graham DW,Kahn LH,Morley PS,Salois MJ,Simjee S,Singer RS,Smith TC,Storrs C,Wittum TE

    更新日期:2019-04-01 00:00:00

  • From the model of El Sistema in Venezuela to current applications: learning and integration through collective music education.

    abstract::Over the last years, El Sistema--the Venezuelan project started in 1975 and now acknowledged worldwide as the most significant example of collective music education--has inspired a profusion of remarkable initiatives on all continents. From the original impulse by founder José Antonio Abreu, strong social principles o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2012.06498.x

    authors: Majno M

    更新日期:2012-04-01 00:00:00

  • Cross-reactive humoral responses to influenza and their implications for a universal vaccine.

    abstract::Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. As effective vaccines against influenza principally rely on the induction of strain-specific neutralizing antibodies for their protective efficacy, drifted escape mutants and genetically reassor...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12012

    authors: Chiu C,Wrammert J,Li GM,McCausland M,Wilson PC,Ahmed R

    更新日期:2013-04-01 00:00:00

  • Is steady-state capitalism viable? A review of the issues and an answer in the affirmative.

    abstract::Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.05966.x

    authors: Lawn P

    更新日期:2011-02-01 00:00:00

  • Antioxidants in nutrition.

    abstract::The harmful effects of oxidative processes in living organisms, in addition to chemical and biochemical media, can be reduced by antioxidants. The efficacy of an antioxidant depends on its reduction potential and kinetics of elimination of diverse free radicals. Redox potentials and reaction rate constants of selected...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06197.x

    authors: Jovanovic SV,Simic MG

    更新日期:2000-01-01 00:00:00

  • Detection of T.b. rhodesiense trypanosomes in humans and domestic animals in south east Uganda by amplification of serum resistance-associated gene.

    abstract::The human serum resistance-associated (SRA) gene was identified in 28 (80%) of the 35 T.b. rhodesiense trypanosomes from parasitologically confirmed sleeping sickness cases, using the primers designed by Radwanska and in 27 (77.1%) of the same 35 T.b. rhodesiense trypanosomes using the primers designed by Gibson. Howe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1373.041

    authors: Enyaru JC,Matovu E,Nerima B,Akol M,Sebikali C

    更新日期:2006-10-01 00:00:00

  • Reporter transgenic mouse models highlight the dual endocrine and neural facet of GnRH receptor function.

    abstract::In the pituitary of mammals, the GnRH receptor (GnRHR) plays crucial roles in the neuroendocrine control of reproductive function. This receptor is specifically expressed by the gonadotrope cells scattered among the five other endocrine cell types constituting the anterior pituitary; it is also expressed in other orga...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05886.x

    authors: Schang AL,Counis R,Magre S,Bleux C,Granger A,Ngô-Muller V,Chenut MC,Ishaq M,Cohen-Tannoudji J,Laverrière JN

    更新日期:2011-03-01 00:00:00

  • The serotonin hypothesis of (auto)aggression. Critical appraisal of the evidence.

    abstract::Based on the relation found to exist between low CSF 5-HIAA and suicide attempt, in particular violent suicide attempt, both in depressed and in so-called nondepressed suicide attempters, the conclusion was drawn that decreased central 5-HT metabolism is related to (auto)aggression, rather than to depression. We chall...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb27895.x

    authors: Van Praag HM,Plutchik R,Conte H

    更新日期:1986-01-01 00:00:00

  • Dendritic cell function in vivo during the steady state: a role in peripheral tolerance.

    abstract::The avoidance of autoimmunity requires mechanisms to actively silence or tolerize self reactive T cells in the periphery. During infection, dendritic cells are not only capturing microbial antigens, but also are processing self antigens from dying cells as well as innocuous environmental proteins. Since the dendritic ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb06029.x

    authors: Steinman RM,Hawiger D,Liu K,Bonifaz L,Bonnyay D,Mahnke K,Iyoda T,Ravetch J,Dhodapkar M,Inaba K,Nussenzweig M

    更新日期:2003-04-01 00:00:00

  • Investigation of arthritic joint destruction by a novel fibroblast-based model.

    abstract::The key pathologic mechanism in rheumatoid arthritis (RA) is the destruction of cartilage by fibroblasts. In a severe combined immunodeficient (SCID) mouse model, this process can be modulated by gene transfer using invasive LS48 fibroblasts. This study aims to investigate the effect of interleukins (IL) -11 and -12 o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1361.070

    authors: Sack U,Sehm B,Kahlenberg F,Murr A,Lehmann J,Tannapfel A,Uberla K,Moessner A,Dietrich A,Emmrich F,Lange F,Jungel A,Braun JM,Anderegg U

    更新日期:2005-06-01 00:00:00

  • Regulation of cardiac Na+/Ca2+ exchanger by phospholemman.

    abstract::Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1387.004

    authors: Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

    更新日期:2007-03-01 00:00:00

  • Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs.

    abstract::In this chapter, we have presented evidence for several potential levels of interaction of NT/N gene products with dopaminergic systems of the brain. We have focused on one manifestation of this interaction related to the effects of antipsychotic drugs on expression of the NT/N gene in two anatomically discrete popula...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb27339.x

    authors: Merchant KM,Dobie DJ,Dorsa DM

    更新日期:1992-01-01 00:00:00

  • Behavioral consequences of methamphetamine-induced neurotoxicity in mice: relevance to the psychopathology of methamphetamine addiction.

    abstract::Methamphetamine (METH) is a major drug of abuse in the United States. A high dose of METH given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (DA), and DA-transporter (DAT) binding sites in the striatum. In human METH-abusers, a marked decrease of the DAT in the caudate puta...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04156.x

    authors: Itzhak Y,Ali SF

    更新日期:2002-06-01 00:00:00

  • The effect of camptothecin on topoisomerase I catalysis.

    abstract::The existence of a covalent intermediate in topoisomerase I catalysis allows uncoupling of the cleavage and ligation half-reactions on partially single-stranded DNA substrates containing a highly preferred interaction site. Using this model DNA substrate system we have demonstrated that the cleavage reaction requires ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb26376.x

    authors: Christiansen K,Westergaard O

    更新日期:1996-12-13 00:00:00

  • Jitter analysis with concentric needle electrodes.

    abstract::Because of certain restrictions in medical praxis, reusable materials are only allowed in some countries. This also applies to electrodes for electromyography; the special single-fiber electromyography electrode must be replaced. This article gives some details of the possibilities of using an alternative-a small conc...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2012.06775.x

    authors: Stålberg E

    更新日期:2012-12-01 00:00:00

  • Genomic searches for genes that influence atherosclerosis and its risk factors.

    abstract::We are performing genomic searches in randomly ascertained families to identify new quantitative trait loci (QTLs) that influence atherosclerosis and its risk factors. The genetic markers used for genomic searches are random microsatellite markers distributed throughout the human chromosomes. These markers are used fo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06295.x

    authors: Hixson JE,Blangero J

    更新日期:2000-05-01 00:00:00

  • The role of electronic health records in clinical reasoning.

    abstract::Electronic health records (eHRs) play an increasingly important role in documentation and exchange of information in multi-and interdisciplinary patient care. Although eHRs are associated with mixed evidence in terms of effectiveness, they are undeniably the health record form of the future. This poses several learnin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13849

    authors: Berndt M,Fischer MR

    更新日期:2018-12-01 00:00:00

  • Plasma levels of AGE peptides in type 1 diabetic patients are associated with serum creatinine and not with albumin excretion rate: possible role of AGE peptide-associated endothelial dysfunction.

    abstract::Patients with renal impairment have an increased risk for cardiovascular disease, which may be the result of advanced glycation end products (AGEs). The aim of this study was to investigate the levels of AGE peptides in relation to kidney function and to study the relationship of AGE peptides with endothelial function...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1333.075

    authors: Schalkwijk CG,Ter Wee PM,Stehouwer CD

    更新日期:2005-06-01 00:00:00

  • Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients.

    abstract::The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. The contribution of this DQ molecule to overall disease susceptibility may be genotype dependent. On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated by DRB1*0405 on the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1337.015

    authors: Park Y,Tait BD,Kawasaki E,Rowley M,Mackay IR

    更新日期:2004-12-01 00:00:00

  • New trends in astrodynamics and applications: optimal trajectories for space guidance.

    abstract::This paper represents recent results on the development of optimal analytic solutions to the variation problem of trajectory optimization and their application in the construction of on-board guidance laws. The importance of employing the analytically integrated trajectories in a mission design is discussed. It is ass...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1370.002

    authors: Azimov D,Bishop R

    更新日期:2005-12-01 00:00:00

  • Is oral tolerance correlated with IgE levels and mast cell numbers?

    abstract::A triple genetic association between serum IgE levels, mast cell numbers, and susceptibility to oral tolerance was observed in mice genetically selected to extreme phenotypes of oral tolerance (susceptibility and resistance), suggesting a coadaptation of genes controlling these traits. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1309.046

    authors: da Silva AC,Silva MF,Bianchi C,Ribeiro RC,Nóbrega A,Sant'anna O

    更新日期:2004-12-01 00:00:00

  • Therapeutic approaches to pulmonary hypertension in hemoglobinopathies: Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathy.

    abstract::New approaches to the treatment of pulmonary arterial hypertension (PH) have increased symptomatic relief and prolonged survival. PH is a common sequela of the hemoglobinopathies, but the use of standard oral treatment options is limited because of toxicity and poor effectiveness. Sildenafil citrate is a selective and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1345.070

    authors: Derchi G,Forni GL

    更新日期:2005-01-01 00:00:00

  • Shikonin production by extractive cultivation in transformed-suspension and hairy root cultures of Lithospermum erythrorhizon.

    abstract::Effects of in situ extraction, fungal elicitation, a permeabilizing agent, and the oxygen transfer rate on shikonin production in transformed suspension and hairy root cultures of Lithospermum erythrorhizon were studied. Shikonin production with in situ extraction in transformed cell and hairy root cultures by n-hexad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb44395.x

    authors: Sim SJ,Kim DJ,Chang HN

    更新日期:1994-11-30 00:00:00

  • Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.

    abstract::Formaldehyde was administered for 104 weeks in drinking water supplied ad libitum at concentrations of 1500, 1000, 500, 100, 50, 10, or 0 mg/L to groups of 50 male and 50 female Sprague-Dawley rats beginning at seven weeks of age. Control animals (100 males and 100 females) received tap water only. Acetaldehyde was ad...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04926.x

    authors: Soffritti M,Belpoggi F,Lambertin L,Lauriola M,Padovani M,Maltoni C

    更新日期:2002-12-01 00:00:00

  • Visual motion perception at the time of saccadic eye movements and its relation to spatial mislocalization.

    abstract::The same retinal image motion can be produced by a variety of combinations of eye and target motion. In natural conditions, extraretinal information disambiguates retinal information for motion perception. By controlling the timing of visual motion with respect to saccades, it was possible to appraise the roles for mo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.015

    authors: Lee C,Lee J

    更新日期:2005-04-01 00:00:00

  • Alterations in biodistribution of 11C-methamphetamine (MAP), 14C-MAP, and 123I-N-isopropyl-iodoamphetamine (IMP) in MAP- and cocaine-sensitized animals.

    abstract::Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb25964.x

    authors: Numachi Y,Yoshida S,Inosaka T,Sato M,Mizugaki M,Kimura K,Hishinuma T

    更新日期:1992-06-28 00:00:00

  • Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols.

    abstract::Tocopherols, which exist in alpha, beta, gamma, and delta forms, are antioxidative nutrients also known as vitamin E. Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. In the present s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05561.x

    authors: Yang CS,Lu G,Ju J,Li GX

    更新日期:2010-08-01 00:00:00

  • Crosstalk between tumor T lymphocytes and reactive T lymphocytes in cutaneous T cell lymphomas.

    abstract::We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03708.x

    authors: Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

    更新日期:2001-09-01 00:00:00

  • Some scientific and organizational challenges in cancer immunology.

    abstract::This volume provides a small sampling of the rapidly growing science of cancer immunology. Growth in the field includes advances on the requirements for immunization or vaccination and the ways in which immunity can be suppressed or blocked, including active tumor-based mechanisms. I would like to introduce the papers...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2009.05060.x

    authors: Steinman RM

    更新日期:2009-09-01 00:00:00

  • Immunofluorescence studies of a possible prethymic T-cell differentiation in congenitally athymic (nude) mice.

    abstract::A rabbit antimouse brain theta reagent was made specific for cells of the T lineage by absorption in vivo in nude mice. When used in double fluorescence together with an antimouse immunoglobulin reagent, four types of cells were found in spleen and lymph nodes of both normal and nude mice: Ig+thetaBr-, Ig-thetaBr+, Ig...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1975.tb29173.x

    authors: Loor F,Roelants GE

    更新日期:1975-06-30 00:00:00