Differential effects of donepezil on methamphetamine and cocaine dependencies.

Abstract:

:Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine-conditioned place preference (CPP) and locomotor sensitization to cocaine. In the present study, we investigated the effects of donepezil on methamphetamine (METH)-induced behavioral changes in mice. In counterbalanced CPP tests, the intraperitoneal (i.p.) administration of 3 mg/kg donepezil prior to 2 mg/kg METH i.p. failed to inhibit METH CPP, whereas pretreatment with 3 mg/kg donepezil abolished the CPP for cocaine (10 mg/kg, i.p.). Similarly, in locomotor sensitization experiments, i.p. administration of 1 mg/kg donepezil prior to 2 mg/kg METH i.p. failed to inhibit locomotor sensitivity to METH, whereas pretreatment with 1 mg/kg donepezil significantly inhibited locomotor sensitivity to cocaine (10 mg/kg, i.p.). These results suggest that donepezil may be a useful tool for treating cocaine dependence but not for treating METH dependence. The differences in the donepezil effects on addictive behaviors induced by METH and cocaine might be due to differences in the involvement of acetylcholine in the mechanisms of METH and cocaine dependencies.

journal_name

Ann N Y Acad Sci

authors

Takamatsu Y,Yamanishi Y,Hagino Y,Yamamoto H,Ikeda K

doi

10.1196/annals.1369.042

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

418-26

eissn

0077-8923

issn

1749-6632

pii

1074/1/418

journal_volume

1074

pub_type

杂志文章
  • Synaptic structure and function in transgenic APP mice.

    abstract::Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05558.x

    authors: Ashe KH

    更新日期:2000-01-01 00:00:00

  • Changes in gait patterns induced by rhythmic auditory stimulation for adolescents with acquired brain injury.

    abstract::The effects of rhythmic auditory stimulation (RAS) on gait in adolescents with acquired brain injury (ABI) were investigated. A total of 14 adolescents with ABI were initially recruited, and 12 were included in the final analysis (n = 6 each). They were randomly assigned to the experimental (RAS) or the control (conve...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/nyas.13294

    authors: Kim SJ,Shin YK,Yoo GE,Chong HJ,Cho SR

    更新日期:2016-12-01 00:00:00

  • Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo.

    abstract::Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (-)Huperzine A resulted in the racemic mixture of (+/-)Huperzine A. We have therefore compared the in vitro and in vivo effects of (+/-)Huperzine A with those of (-)Huperzine A in ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb23071.x

    authors: Hanin I,Tang XC,Kindel GL,Kozikowski AP

    更新日期:1993-09-24 00:00:00

  • Are there multiple ways to direct attention in working memory?

    abstract::In visual working memory tasks, memory for an item is enhanced if participants are told that the item is relatively more valuable than others presented within the same trial. Experiment 1 explored whether these probe value boosts (termed prioritization effects in previous literature) are affected by probe frequency (i...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13634

    authors: Atkinson AL,Berry EDJ,Waterman AH,Baddeley AD,Hitch GJ,Allen RJ

    更新日期:2018-07-01 00:00:00

  • Sensory-induced activation of pattern generators in the absence of supraspinal control.

    abstract::Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory-activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back-labeled funicular pathways suggest t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05424.x

    authors: Lev-Tov A,Etlin A,Blivis D

    更新日期:2010-06-01 00:00:00

  • Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3-NPA.

    abstract::3-Nitropropionic acid (3-NPA) is a model mitochondrial inhibitor that causes selective neurodegeneration in brain. 3-NPA-induced neurodegeneration occurs via a secondary neurotoxicity, caused initially by ATP depletion and redox changes in the cell. It is known that the hippocampal degeneration caused by mitochondrial...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1344.014

    authors: Przybyla-Zawislak BD,Thorn BT,Ali SF,Dennis RA,Amato A,Virmani A,Binienda ZK

    更新日期:2005-08-01 00:00:00

  • Properties of entorhinal cortex projection cells to the hippocampal formation.

    abstract::There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06722.x

    authors: Heinemann U,Schmitz D,Eder C,Gloveli T

    更新日期:2000-06-01 00:00:00

  • Laser-induced fluorescence for esophageal cancer and dysplasia diagnosis.

    abstract::A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb08192.x

    authors: Vo-Dinh T,Panjehpour M,Overholt BF

    更新日期:1998-02-09 00:00:00

  • Common molecular pathways in skeletal morphogenesis and repair.

    abstract::The formation of bone is a continual process in vertebrate development, initiated during fetal development and persisting in adulthood in the form of remodeling and repair. The remarkable capacity of skeletal tissues to regenerate has led to the hypothesis that the molecular signaling pathways regulating skeletogenesi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10105.x

    authors: Ferguson CM,Miclau T,Hu D,Alpern E,Helms JA

    更新日期:1998-10-23 00:00:00

  • Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin.

    abstract::Our previous studies have demonstrated that the methanol extract of heat-processed Panax ginseng C.A. Meyer exerts antioxidative, antiinflammatory, and anti-tumor-promoting effects. In the present study, we examined the antiinflammatory effects of several ginsenosides (Rb(1), Rc, Re, Rg(1), Rg(3)) derived from P. gins...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04672.x

    authors: Surh YJ,Lee JY,Choi KJ,Ko SR

    更新日期:2002-11-01 00:00:00

  • Soluble HLA class I and class II molecules in relapsing-remitting multiple sclerosis: acute response to interferon-beta1a treatment and their use as markers of disease activity.

    abstract::During relapses in relapsing-remitting multiple sclerosis (RRMS), serum soluble HLA class I surface antigen (sHLA-I) levels are reported to either decrease or remain unchanged, whereas serum sHLA-II levels increase. Interferon-beta1b therapy was recently reported to increase serum sHLA-I in RRMS. In the present prospe...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1361.052

    authors: Minagar A,Adamashvilli I,Jaffe SL,Glabus MF,Gonzalez-Toledo E,Kelley RE

    更新日期:2005-06-01 00:00:00

  • Dehydroepiandrosterone enhances influenza immunization in aged mice.

    abstract::The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb17391.x-i1

    authors: Danenberg HD,Ben-Yehuda A,Zakay-Rones Z,Friedman G

    更新日期:1995-12-29 00:00:00

  • Protein oxidation.

    abstract::The oxidative modification of proteins by reactive species, especially reactive oxygen species, is implicated in the etiology or progression of a panoply of disorders and diseases. These reactive species form through a large number of physiological and non-physiological reactions. An increase in the rate of their prod...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06187.x

    authors: Stadtman ER,Levine RL

    更新日期:2000-01-01 00:00:00

  • Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B.

    abstract::The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04484.x

    authors: Yoo SH,So SH,Huh YH,Park HY

    更新日期:2002-10-01 00:00:00

  • Isolation and partial characterization of four fluorophores formed by nonenzymatic browning of methylglyoxal and glutamine-derived ammonia.

    abstract::An aqueous solution of L-glutamine (50 mmol/L) and methylglyoxal (100 mmol/L) was incubated at 120 degrees C for 3 h in a 200 mmol/L phosphate buffer (pH 7.4). Four major fluorophores were revealed on the HPLC chromatogram. The same four fluorophores were obtained from the heating of a mixture of ammonia and methylgly...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1433.025

    authors: Niquet C,Pilard S,Mathiron D,Tessier FJ

    更新日期:2008-04-01 00:00:00

  • The mitogenic activity of polyadenylic-polyuridyclic acid complexes.

    abstract::Polyadenylic-polyuridylic acid complexes (poly A:U) at the 1-5 mu g level, were mitogenic for spleen cells when given intravenously to normal Balb or cortisone-treated mice. Similarly, mitogenicity was evident when poly A:U was added to tissue culture fluids containing spleen cells from normal or cortisone-treated mic...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1975.tb29085.x

    authors: Han IH,Johnson AG

    更新日期:1975-02-28 00:00:00

  • DNA probes for the identification of Coxiella burnetti strains.

    abstract::Isolation of Coxiella Burnetii in the standard laboratory setting is hazardous; therefore most diagnoses are based on retrospective detection of a rising antibody titer to C. burnetti. As a result, this disease is usually undiagnosed or misdiagnosed. Methods for the rapid detection of C. burnetti have now been develop...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1990.tb42253.x

    authors: Frazier ME,Mallavia LP,Samuel JE,Baca OG

    更新日期:1990-01-01 00:00:00

  • Contraception today.

    abstract::Modern contraceptive methods represent more than a technical advance: they are the instrument of a true social revolution-the "first reproductive revolution" in the history of humanity, an achievement of the second part of the 20th century, when modern, effective methods became available. Today a great diversity of te...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1365.002

    authors: Benagiano G,Bastianelli C,Farris M

    更新日期:2006-12-01 00:00:00

  • Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury.

    abstract::The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, "ecstasy") is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia tha...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1432.052

    authors: Sharma HS,Ali SF

    更新日期:2008-10-01 00:00:00

  • Autophagy.

    abstract::Autophagy is a major intracellular pathway for the degradation and recycling of long-lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms. Autophagic vacuole formation is also activ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1363.015

    authors: Kelekar A

    更新日期:2005-12-01 00:00:00

  • Onset of odorant receptors.

    abstract::Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regardi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04366.x

    authors: Rodriguez-Gil DJ,Treloar HB,Miller A,Two A,Iwema C,Greer CA

    更新日期:2009-07-01 00:00:00

  • Collaborative study for the evaluation of multiple simultaneous markers in lung cancer.

    abstract::The search for tumor markers suitable for use in diagnosis and management of patients with lung cancer has met with limited success because each available marker lacks sufficient sensitivity and specificity. We have begun a collaborative study to evaluate multiple simultaneous serum markers to determine whether there ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb32885.x

    authors: McIntire KR,Radovich BT,Gail MH,Go VL

    更新日期:1983-01-01 00:00:00

  • Acid-base interactions during exocrine pancreatic secretion. Primary role for ductal bicarbonate in acinar lumen function.

    abstract::The role of acid-base interactions during coordinated acinar and duct cell secretion in the exocrine pancreas is described. The sequence of acid-base events may be summarized as follows: (1) Sorting of secretory proteins and membrane components into the regulated secretory pathway of pancreatic acinar cells is trigger...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb44066.x

    authors: Freedman SD,Scheele GA

    更新日期:1994-03-23 00:00:00

  • Surface expression of fractalkine receptor (CX3CR1) on CD4+/CD28 T cells in RA patients and correlation with atherosclerotic damage.

    abstract::Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis. Fractalkine, a CX3C/chemokine (CX3CL1), mediates monocytes-macrophage infiltration in activated endothelium, suggesting its specific role in atherosclerosis-related inflammation. In this study, we evaluate the following in early RA patients: the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1381.004

    authors: Pingiotti E,Cipriani P,Marrelli A,Liakouli V,Fratini S,Penco M,Giacomelli R

    更新日期:2007-06-01 00:00:00

  • Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.

    abstract::Relaxin (RLX) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor gamma (PPARgamma), raising the possibility that a mechanism for RLX's antifibrotic effects may involve activation of the PPARgamma pathway. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03808.x

    authors: Singh S,Bennett RG

    更新日期:2009-04-01 00:00:00

  • Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse.

    abstract::Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04041.x

    authors: Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

    更新日期:2009-05-01 00:00:00

  • Idiotypes of anti-major histocompatibility complex antibodies.

    abstract::Our studies to date indicate that treatment with anti-idiotype to monoclonal anti-MHC antibodies can markedly influence the repertoire of anti-MHC antibodies expressed. The antibodies discussed here appear to represent two classes, one of which is public, probably representing expression of a germ line gene, and the s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb18074.x

    authors: Sachs DH,Bluestone JA,Epstein SL,Rabinowitz R

    更新日期:1983-01-01 00:00:00

  • Mitigation strategies to reduce acrylamide formation in fried potato products.

    abstract::Potato products contain high amounts of acrylamide, which sometimes exceeds the concentration of 1 mg/L. However, many strategies for acrylamide reduction in potato products are possible. In this work, the different approaches for reducing acrylamide formation have been reviewed, keeping in mind that in the applicatio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1433.051

    authors: Morales F,Capuano E,Fogliano V

    更新日期:2008-04-01 00:00:00

  • Can circulatory fetal DNA be used to study placentation at high altitude?

    abstract::Pregnancy at high altitude (>2700 m) is associated with higher rates of fetal growth restriction and preeclampsia as well as alterations in placentation, including increased villous vascularization and reduced remodeling of maternal spiral arteries. Because circulatory fetal DNA concentrations were shown to be enhance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1318.020

    authors: Zhong XY,Wang Y,Chen S,Labu,Pubuzhuoma,Gesangzhuogab,Ouzhuwangmu,Hahn C,Holzgreve W,Hahn S

    更新日期:2004-06-01 00:00:00

  • Cancer immunomics: from serological proteome analysis to multiple affinity protein profiling.

    abstract::Cancer remains one of the leading causes of death worldwide. Thus, to identify any useful biomarkers is still a need. We performed "cancer immunomics" to identify autoantibody signatures produced in response to the presence of either breast or colorectal cancer. SERological proteome analysis (SERPA) was performed by t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1381.024

    authors: Hardouin J,Lasserre JP,Sylvius L,Joubert-Caron R,Caron M

    更新日期:2007-06-01 00:00:00