Abstract:
:We have evaluated different behavioral parameters in ICR (CD1) female mice of three different ages (38-39 weeks: mature; 62 weeks: late mature; 90 weeks: old), and addressed the effects of an enriched housing condition. We employed the following battery of tests: Holeboard, open field, elevated plus-maze (EPM), and forced swimming test (FST). The results suggest that aging process differentially affects diverse aspects of behavior. With respect to motor activity, late mature animals were more affected by enrichment, whereas old animals appeared to be more affected when emotional responses were considered. We propose that the diminished percentage of time in the open arms of the EPM showed by enriched mice may be indicative of decreased novelty seeking, whereas their decreased climbing behavior may indicate a reduced escape-related behavior in an inescapable situation.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Zambrana C,Marco EM,Arranz L,de Castro NM,Viveros MP,de la Fuente Mdoi
10.1196/annals.1395.060subject
Has Abstractpub_date
2007-04-01 00:00:00pages
543-52eissn
0077-8923issn
1749-6632pii
1100/1/543journal_volume
1100pub_type
杂志文章abstract::Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...
journal_title:Annals of the New York Academy of Sciences
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