Abstract:
:Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction. However, little is known about the target antigens of CD8(+) T cells in human T1D patients. The aim of this study was to assess whether an epitope derived from the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), IGRP(265-273,) which has recently been identified as a target in non-obese diabetic (NOD) mice and is fully homologous to the human epitope, is a target of human diabetogenic CD8(+) T cells. We isolated a human CD8 T cell clone against this epitope, which confirms that this IGRP epitope is shared across species.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Unger WW,Pinkse GG,Mulder-van der Kracht S,van der Slik AR,Kester MG,Ossendorp F,Drijfhout JW,Serreze DV,Roep BOdoi
10.1196/annals.1394.024subject
Has Abstractpub_date
2007-04-01 00:00:00pages
192-5eissn
0077-8923issn
1749-6632pii
annals.1394.024journal_volume
1103pub_type
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