The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding.

abstract：:Nanomedicine is the application of nanotechnology to the discipline of medicine: the use of nanoscale materials for the diagnosis, monitoring, control, prevention, and treatment of disease. Nanomedicine holds tremendous promise to revolutionize medicine across disciplines and specialties, but this promise has yet to b...

journal_title：Annals of the New York Academy of Sciences

authors： Tinkle S,McNeil SE,Mühlebach S,Bawa R,Borchard G,Barenholz YC,Tamarkin L,Desai N

更新日期：2014-04-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:The current concept of stress in plants has been well developed over the past 60 years. Any unfavorable condition or substance that affects or blocks a plant's metabolism, growth, or development is regarded as stress. Vegetation stress can be induced by various natural and anthropogenic stress factors. One has to diff...

journal_title：Annals of the New York Academy of Sciences

authors： Lichtenthaler HK

更新日期：1998-06-30 00:00:00

abstract：:After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the key pathologic events associated with the development of AD. These pathologic events are triggered in AD by impai...

journal_title：Annals of the New York Academy of Sciences

authors： de la Torre JC

更新日期：2000-01-01 00:00:00

abstract：:Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell-to-cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the dige...

journal_title：Annals of the New York Academy of Sciences

authors： Hamzaoui N,Pringault E

更新日期：1998-11-17 00:00:00

abstract：:The signal peptidases from both chicken oviduct and dog pancreas microsomes have been detected by a post-translational assay and, in the case of dog microsomes, by a cotranslational assay. This proteolytic activity is not sensitive to a variety of conventional protease inhibitors under the conditions used in these ass...

journal_title：Annals of the New York Academy of Sciences

authors： Thibodeau SN,Walsh KA

更新日期：1980-01-01 00:00:00

abstract：:Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (tetanus toxoid), that absolute levels of proliferation, minimally detecta...

journal_title：Annals of the New York Academy of Sciences

authors： Narendran P,Elsegood K,Leech NJ,Dayan CM

更新日期：2002-04-01 00:00:00

abstract：:Human speech perception seems to involve the ability to recognize groupings of speech sounds rather than component phonemes, and to distinguish between permuted orders of items within sequences as holistic entities. Humans can use this Holistic Pattern Recognition (HPR) not only with speech and music, but also with se...

journal_title：Annals of the New York Academy of Sciences

authors： Warren RM

更新日期：1976-01-01 00:00:00

abstract：:We propose a model for signaling events induced by fluid shear stress that incorporates many of the features discussed in this paper (FIG. 4). First, heterotrimeric G-proteins, as well as a small G-proteins, are activated by flow. Indeed, a G protein appears to be required for ERK1/2 activation by flow because ERK1/2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Ishida T,Takahashi M,Corson MA,Berk BC

更新日期：1997-04-15 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effect...

journal_title：Annals of the New York Academy of Sciences

authors： Hopkins DR,Richards FO Jr,Ruiz-Tiben E,Emerson P,Withers PC Jr

更新日期：2008-01-01 00:00:00

abstract：:Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these recep...

journal_title：Annals of the New York Academy of Sciences

authors： Myslivecek J,Tillinger A,Novakova M,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:Air particulate activity over all of the Northern Hemisphere reached its highest levels since the termination of nuclear weapons testing--sometimes up to 1 million times higher than before the Chernobyl contamination. There were essential changes in the ionic, aerosol, and gas structure of the surface air in the heavi...

journal_title：Annals of the New York Academy of Sciences

authors： Yablokov AV,Nesterenko VB,Nesterenko AV

更新日期：2009-11-01 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:Among the five enzyme complexes in the oxidative phosphorylation system, NADH-coenzyme Q oxidoreductase (also called complex I) is the largest, most intricate, and least understood. This enzyme complex spans the inner mitochondrial membrane and catalyzes the first step of electron transfer by the oxidation of NADH, an...

journal_title：Annals of the New York Academy of Sciences

authors： Lin BY,Kao MC

更新日期：2015-09-01 00:00:00

abstract：:The availability of new food composition carotenoid values for fruits and vegetables increases our ability to test hypotheses concerning the role of antioxidant nutrients and cancer risk. To estimate the usual carotenoid intakes, a quantitative diet history covering a one-year period is recommended for epidemiologic s...

journal_title：Annals of the New York Academy of Sciences

authors： Hankin JH,Le Marchand L,Kolonel LN,Wilkens LR

更新日期：1993-12-31 00:00:00

abstract：:Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

journal_title：Annals of the New York Academy of Sciences

authors： Damjanović ZM,Rakocević MM

更新日期：2005-06-01 00:00:00

abstract：:Our molecular studies have revealed the existence of a large number of different subunits or subtypes for the NMDA and metabotropic glutamate receptors. The individual receptors show functional variabilities and distinct expression patterns in the CNS. The NMDA receptors belong to the ligand-gated ion channel family a...

journal_title：Annals of the New York Academy of Sciences

authors： Masu M,Nakajima Y,Moriyoshi K,Ishii T,Akazawa C,Nakanashi S

更新日期：1993-12-20 00:00:00

abstract：:Reducing emissions from deforestation and forest degradation (REDD+) provides financial compensation to land owners who avoid converting standing forests to other land uses. In this paper, we review the main opportunities and challenges for REDD+ implementation, including expectations for REDD+ to deliver on multiple ...

journal_title：Annals of the New York Academy of Sciences

authors： Venter O,Koh LP

更新日期：2012-02-01 00:00:00

abstract：:A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-K...

journal_title：Annals of the New York Academy of Sciences

authors： Maruyama N,Ishigami A,Kuramoto M,Handa S,Kubo S,Imasawa T,Seyama K,Shimosawa T,Kasahara Y

更新日期：2004-06-01 00:00:00

abstract：:Our studies to date indicate that treatment with anti-idiotype to monoclonal anti-MHC antibodies can markedly influence the repertoire of anti-MHC antibodies expressed. The antibodies discussed here appear to represent two classes, one of which is public, probably representing expression of a germ line gene, and the s...

journal_title：Annals of the New York Academy of Sciences

authors： Sachs DH,Bluestone JA,Epstein SL,Rabinowitz R

更新日期：1983-01-01 00:00:00

abstract：:Signal hyperintensities on magnetic resonance imaging (MRI) are increased in the white matter (WMH) and deep gray matter in dementia and depression and may have similar pathologies. However, no previous study has examined WMH in subjects with major depression. We carried out in vitro MRI on brain tissue from elderly s...

journal_title：Annals of the New York Academy of Sciences

authors： Thomas AJ,Perry R,Barber R,Kalaria RN,O'Brien JT

更新日期：2002-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a serious, chronic condition that, without early recognition and treatment, leads to progressive right heart failure and death. The dual endothelin receptor antagonist macitentan was designed through a deliberate discovery process to maximize endothelin-axis blockade while impr...

journal_title：Annals of the New York Academy of Sciences

authors： Selej M,Romero AJ,Channick RN,Clozel M

更新日期：2015-11-01 00:00:00

abstract：:In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the noninvasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. This widespread ...

journal_title：Annals of the New York Academy of Sciences

authors： Granger DA,Kivlighan KT,el-Sheikh M,Gordis EB,Stroud LR

更新日期：2007-03-01 00:00:00

abstract：:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

journal_title：Annals of the New York Academy of Sciences

authors： Porat S,Simantov R

更新日期：1999-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of insulin-secreting pancreatic β cells. In humans with T1D and in nonobese diabetic (NOD) mice (a murine model for human T1D), autoreactive T cells cause β-cell destruction, as transfer or deletion of these cells induces or...

journal_title：Annals of the New York Academy of Sciences

authors： Padgett LE,Broniowska KA,Hansen PA,Corbett JA,Tse HM

更新日期：2013-04-01 00:00:00

abstract：:Growth and pubertal disturbances are the commonest endocrinopathies in homozygous thalassemia, accounting for significant morbidity in 70-80% children and adolescents globally. This review focuses on the pathophysiology of the endocrinopathy from a historical perspective and altered natural history induced by better c...

journal_title：Annals of the New York Academy of Sciences

authors： Chatterjee R,Bajoria R

更新日期：2010-08-01 00:00:00

abstract：:We compare diverging evolution of a two-component (gas+stars) galactic disk embedded in a "live" halo with that of an identical pure stellar disk. Our modeling supports the conjecture that the growth of central concentration in galaxies dissolves the main family of regular orbits in the stellar bar and assists in the ...

journal_title：Annals of the New York Academy of Sciences

authors： Shlosman I,Heller C,Berentzen I

更新日期：1998-12-30 00:00:00

abstract：:These experiments sought to: (1) determine if alpha 2/I1 agonists that are topically active on the eye have similar effects on intraocular pressure when applied to the CNS and (2) ascertain whether these agents lower IOP, in part, via central alpha 2 receptors and/or imidazoline (I1) receptors. New Zealand White rabbi...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell WR,Potter DE

更新日期：1995-07-12 00:00:00

abstract：:This paper discusses the repatriation of human remains to indigenous peoples in Australia and the United States and the role anthropologists play in the construction of past, present, and future identities for contemporary indigenous peoples. Using examples from both countries, I suggest that many of the participants ...

journal_title：Annals of the New York Academy of Sciences

authors： Cantwell AM

更新日期：2000-01-01 00:00:00